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2J7Q

Crystal structure of the ubiquitin-specific protease encoded by murine cytomegalovirus tegument protein M48 in complex with a ubquitin-based suicide substrate

Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A1234
ChainResidue
APRO41
AASP44
ASER47
AHOH2045
AHOH2047
AHOH2053

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B1076
ChainResidue
DLYS29
DHOH2038
BGLU18
BHOH2015
BHOH2016

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG D1076
ChainResidue
BLYS29
BHOH2019
BHOH2025
DGLU18
DHOH2026
DHOH2027

site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GVE A1235
ChainResidue
AGLY20
ASER21
ACYS23
ATYR76
AVAL140
AHIS141
AHOH2246
BGLY75
DGLN31

site_idAC5
Number of Residues14
DetailsBINDING SITE FOR RESIDUE PG4 B1077
ChainResidue
AGLU87
ALEU119
AARG126
AALA151
ATHR152
ACYS171
AASP172
AASP173
APHE174
ATHR175
AHOH2110
AHOH2163
BHOH2082
BHOH2083

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GVE C1235
ChainResidue
CGLY20
CCYS23
CTYR76
CVAL140
CPHE141
DGLY75

site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL C1234
ChainResidue
CPRO129
CPRO131
CVAL132
CTYR133
CVAL198
CTYR221
CHOH2277

Functional Information from PROSITE/UniProt
site_idPS00299
Number of Residues26
DetailsUBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD
ChainResidueDetails
BLYS27-ASP52

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsSITE: Interacts with activating enzyme
ChainResidueDetails
BARG54
BARG72
DARG54
DARG72

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Essential for function
ChainResidueDetails
BHIS68
DHIS68

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291
ChainResidueDetails
BSER65
DSER65

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457
ChainResidueDetails
BTHR66
DTHR66

site_idSWS_FT_FI5
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603
ChainResidueDetails
BLYS6
DLYS6

site_idSWS_FT_FI6
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106
ChainResidueDetails
BLYS63
DLYS63

site_idSWS_FT_FI7
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144
ChainResidueDetails
BLYS11
BLYS48
DLYS11
DLYS48

site_idSWS_FT_FI8
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860
ChainResidueDetails
BLYS27
DLYS27

site_idSWS_FT_FI9
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127
ChainResidueDetails
BLYS29
DLYS29

site_idSWS_FT_FI10
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577
ChainResidueDetails
BLYS33
DLYS33

226707

PDB entries from 2024-10-30

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