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6PBW
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BU of 6pbw by Molmil
Crystal structure of Fab667 complex
分子名称: Fab667 heavy chain, Fab667 light chain, GLYCEROL, ...
著者Oyen, D, Wilson, I.A.
登録日2019-06-14
公開日2020-03-04
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.058 Å)
主引用文献Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein.
Plos Pathog., 16, 2020
6PBV
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BU of 6pbv by Molmil
Crystal structure of Fab668 complex
分子名称: 1,2-ETHANEDIOL, Fab668 heavy chain, Fab668 light chain, ...
著者Oyen, D, Wilson, I.A.
登録日2019-06-14
公開日2020-03-04
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.566 Å)
主引用文献Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein.
Plos Pathog., 16, 2020
5W3Q
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BU of 5w3q by Molmil
L28F E.coli DHFR in complex with NADPH
分子名称: CALCIUM ION, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Oyen, D, Wright, P.E, Wilson, I.A.
登録日2017-06-08
公開日2017-08-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.401 Å)
主引用文献Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion.
J. Am. Chem. Soc., 139, 2017
3K74
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BU of 3k74 by Molmil
Disruption of protein dynamics by an allosteric effector antibody
分子名称: Dihydrofolate reductase, Nanobody
著者Oyen, D, Srinivasan, V, Steyaert, J, Barlow, J.
登録日2009-10-12
公開日2010-10-20
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition.
J.Mol.Biol., 407, 2011
5CC9
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BU of 5cc9 by Molmil
L28F E.coli dihydrofolate reductase complexed with 5,10-dideazatetrahydrofolate and oxidized nicotinamide adenine dinucleotide phosphate
分子名称: 5,10-DIDEAZATETRAHYDROFOLIC ACID, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Oyen, D, Wright, P.E.
登録日2015-07-01
公開日2015-08-05
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.199 Å)
主引用文献Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway.
J.Am.Chem.Soc., 137, 2015
5CCC
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BU of 5ccc by Molmil
wild-type E.coli dihydrofolate reductase complexed with 5,10-dideazatetrahydrofolate and oxidized nicotinamide adenine dinucleotide phosphate
分子名称: 5,10-DIDEAZATETRAHYDROFOLIC ACID, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Oyen, D, Wright, P.E.
登録日2015-07-01
公開日2015-08-05
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway.
J.Am.Chem.Soc., 137, 2015
4EIG
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BU of 4eig by Molmil
CA1698 camel antibody fragment in complex with DHFR
分子名称: CA1698 camel antibody fragment, Dihydrofolate reductase
著者Oyen, D, Srinivasan, V.
登録日2012-04-05
公開日2013-04-24
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
4EIZ
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BU of 4eiz by Molmil
Structure of Nb113 bound to apoDHFR
分子名称: Dihydrofolate reductase, Nb113 Camel antibody fragment
著者Oyen, D, Srinivasan, V.
登録日2012-04-06
公開日2013-04-24
最終更新日2013-10-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
6AXL
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BU of 6axl by Molmil
Crystal structure of Fab317 complex
分子名称: Fab317 heavy chain, Fab317 light chains, Peptide ACE-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-NH2
著者Oyen, D, Wilson, I.A.
登録日2017-09-07
公開日2017-11-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6AXK
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BU of 6axk by Molmil
Crystal structure of Fab311 complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACE-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN, Fab311 heavy chain, ...
著者Oyen, D, Wilson, I.A.
登録日2017-09-07
公開日2017-11-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.103 Å)
主引用文献Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4EJ1
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BU of 4ej1 by Molmil
Binding of Nb113 camelid antibody fragment with the binary DHFR:folate complex
分子名称: Dihydrofolate reductase, FOLIC ACID, Nb113 camelid antibody fragment, ...
著者Oyen, D, Srinivasan, V.
登録日2012-04-06
公開日2013-04-24
最終更新日2013-10-30
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
4FHB
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BU of 4fhb by Molmil
Enhancing DHFR catalysis by binding of an allosteric regulator nanobody (Nb179)
分子名称: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Oyen, D.
登録日2012-06-06
公開日2013-04-24
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
4I1N
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BU of 4i1n by Molmil
R104A-ca1697 nanobody binding to the binary DHFR.folate complex
分子名称: Dihydrofolate reductase, FOLIC ACID, Protein ca1697 (nanobody)
著者Oyen, D, Steyaert, J, Barlow, J.N.
登録日2012-11-21
公開日2013-11-27
実験手法X-RAY DIFFRACTION (1.888 Å)
主引用文献Exploring an alternative antibody interaction mechanism
To be Published
4I13
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BU of 4i13 by Molmil
Nanobody ca1697 binding to the DHFR.folate binary complex
分子名称: Dihydrofolate reductase, FOLIC ACID, Protein ca1697 (nanobody)
著者Oyen, D, Steyaert, J, Barlow, J.N.
登録日2012-11-19
公開日2013-11-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Exploring an alternative antibody interaction mechanism
To be Published
7RA7
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BU of 7ra7 by Molmil
Crystal structure of rabbit anti-HIV Fab 11A
分子名称: 11A Fab heavy chain, 11A Fab light chain, PENTAETHYLENE GLYCOL, ...
著者Oyen, D, Wilson, I.A.
登録日2021-06-30
公開日2022-07-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Limited breadth of anti-HIV Env glycan hole antibodies is further hindered by strain-specific peptide interactions
To Be Published
6VSR
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BU of 6vsr by Molmil
Crystal structure of macaque anti-HIV-1 antibody RM20F
分子名称: RM20F Fab Heavy Chain, RM20F Fab Light Chain, SULFATE ION
著者Oyen, D, Yuan, M, Wilson, I.A.
登録日2020-02-11
公開日2020-09-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.176 Å)
主引用文献Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
Plos Pathog., 16, 2020
6BQB
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BU of 6bqb by Molmil
MGG4 Fab in complex with peptide
分子名称: GLYCEROL, MGG4 Fab heavy chain, MGG4 Fab light chain, ...
著者Oyen, D, Tan, J, Lanzavecchia, A, Wilson, I.A.
登録日2017-11-27
公開日2018-03-07
最終更新日2018-04-25
実験手法X-RAY DIFFRACTION (1.769 Å)
主引用文献A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein.
Nat. Med., 24, 2018
6DID
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BU of 6did by Molmil
HIV Env BG505 SOSIP with polyclonal Fabs from immunized rabbit #3417 post-boost#1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ...
著者Turner, H.L, Cottrell, C.A, Oyen, D, Wilson, I.A, Ward, A.B.
登録日2018-05-23
公開日2018-09-05
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.71 Å)
主引用文献Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization.
Immunity, 49, 2018
7RXJ
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BU of 7rxj by Molmil
Fab236 in complex with the C-terminal alpha-TSR domain of P. falciparum
分子名称: Circumsporozoite protein, Fab236 heavy chain, Fab236 light chain
著者Pholcharee, T, Oyen, D, Wilson, I.A.
登録日2021-08-23
公開日2022-03-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.345 Å)
主引用文献A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum.
Plos Pathog., 18, 2022
7S0X
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BU of 7s0x by Molmil
Fab352 in complex with the C-terminal alphaTSR domain of P. falciparum
分子名称: Circumsporozoite protein, Fab352 heavy chain, Fab352 light chain
著者Pholcharee, T, Oyen, D, Wilson, I.A.
登録日2021-08-31
公開日2022-03-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum.
Plos Pathog., 18, 2022
7RXP
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BU of 7rxp by Molmil
Fab1512 in complex with the C-terminal alpha-TSR domain of P. falciparum
分子名称: Circumsporozoite protein, Fab1512 heavy chain, Fab1512 light chain
著者Pholcharee, T, Oyen, D, Wilson, I.A.
登録日2021-08-23
公開日2022-03-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.761 Å)
主引用文献A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum.
Plos Pathog., 18, 2022
7RXI
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BU of 7rxi by Molmil
Fab234 in complex with the C-terminal alpha-TSR domain of P. falciparum
分子名称: Circumsporozoite protein, Fab234 heavy chain, Fab234 light chain
著者Pholcharee, T, Oyen, D, Wilson, I.A.
登録日2021-08-23
公開日2022-03-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum.
Plos Pathog., 18, 2022
7RXL
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Fab1488 in complex with the C-terminal alpha-TSR domain of P. falciparum
分子名称: Circumsporozoite protein, Fab1488 heavy chain, Fab1488 light chain
著者Pholcharee, T, Oyen, D, Wilson, I.A.
登録日2021-08-23
公開日2022-03-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.823 Å)
主引用文献A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum.
Plos Pathog., 18, 2022
6W05
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BU of 6w05 by Molmil
Crystal structure of Fab356 in complex with NPNA2 peptide from circumsporozoite protein
分子名称: Fab356 heavy chain, Fab356 light chain, NPNA2 peptide
著者Pholcharee, T, Oyen, D, Wilson, I.A.
登録日2020-02-29
公開日2020-07-29
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.516 Å)
主引用文献Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum.
Nat Commun, 12, 2021
6W00
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Crystal structure of Fab239 in complex with NPNA2 peptide from circumsporozoite protein
分子名称: Fab239 heavy chain, Fab239 light chain, Immunoglobulin G-binding protein G, ...
著者Pholcharee, T, Oyen, D, Wilson, I.A.
登録日2020-02-28
公開日2020-07-29
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.853 Å)
主引用文献Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum.
Nat Commun, 12, 2021

 

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