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3IWY
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BU of 3iwy by Molmil
Crystal structure of human MDM2 complexed with D-peptide (12 residues)
Descriptor: D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2
Authors:Pazgier, M, Lu, W.
Deposit date:2009-09-03
Release date:2010-04-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms.
Proc.Natl.Acad.Sci.USA, 398, 2010
3LO2
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BU of 3lo2 by Molmil
Crystal structure of human alpha-defensin 1 (Y21A mutant)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Neutrophil defensin 1, SULFATE ION, ...
Authors:Pazgier, M, Lu, W.
Deposit date:2010-02-03
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO1
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BU of 3lo1 by Molmil
Crystal structure of human alpha-defensin 1 (Y16A mutant)
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, AZIDE ION, Neutrophil defensin 1
Authors:Pazgier, M, Lu, W.
Deposit date:2010-02-03
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LNZ
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BU of 3lnz by Molmil
Crystal structure of human MDM2 with a 12-mer peptide inhibitor PMI (N8A mutant)
Descriptor: 12-mer peptide inhibitor, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2
Authors:Pazgier, M, Lu, W.
Deposit date:2010-02-03
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions.
J.Mol.Biol., 398, 2010
3LOE
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BU of 3loe by Molmil
Crystal structure of human alpha-defensin 1 (F28A mutant)
Descriptor: GLYCEROL, Neutrophil defensin 1, SULFATE ION
Authors:Pazgier, M, Lu, W.
Deposit date:2010-02-03
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO6
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BU of 3lo6 by Molmil
Crystal structure of human alpha-defensin 1 (W26Aba mutant)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Neutrophil defensin 1
Authors:Pazgier, M, Lu, W.
Deposit date:2010-02-03
Release date:2010-03-09
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO4
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BU of 3lo4 by Molmil
Crystal structure of human alpha-defensin 1 (R24A mutant)
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Neutrophil defensin 1
Authors:Pazgier, M, Lu, W.
Deposit date:2010-02-03
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO9
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BU of 3lo9 by Molmil
Crystal structure of human alpha-defensin 1 (W26Ahp mutant)
Descriptor: Neutrophil defensin 1
Authors:Pazgier, M, Lu, W.
Deposit date:2010-02-03
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LVX
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BU of 3lvx by Molmil
Crystal structure of human alpha-defensin 1 (I6A mutant)
Descriptor: GLYCEROL, Neutrophil defensin 1, SULFATE ION
Authors:Pazgier, M, Lu, W.
Deposit date:2010-02-22
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
1ZMH
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BU of 1zmh by Molmil
Crystal structure of human neutrophil peptide 2, HNP-2 (variant Gly16-> D-Ala)
Descriptor: GLYCEROL, HEXAETHYLENE GLYCOL, Neutrophil defensin 2, ...
Authors:Lubkowski, J, Prahl, A, Lu, W.
Deposit date:2005-05-10
Release date:2005-08-16
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005
1ZMI
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BU of 1zmi by Molmil
Crystal structure of human alpha_defensin-2 (variant GLY16->D-ALA), P 32 2 1 space group )
Descriptor: GLYCEROL, Neutrophil defensin 2, SULFATE ION
Authors:Lubkowski, J, Prahl, A, Lu, W.
Deposit date:2005-05-10
Release date:2005-08-16
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005
1ZMK
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BU of 1zmk by Molmil
Crystal structure of human alpha-defensin-2 (variant Gly16-> D-ALA), P 42 21 2 space group
Descriptor: CHLORIDE ION, GLYCEROL, Neutrophil defensin 2
Authors:Lubkowski, J, Prahl, A, Lu, W.
Deposit date:2005-05-10
Release date:2005-08-16
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005
3EQY
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BU of 3eqy by Molmil
Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor
Descriptor: 12-mer peptide inhibitor, GUANIDINE, Mdm4 protein, ...
Authors:Pazgier, M, Lu, W.
Deposit date:2008-10-01
Release date:2009-03-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
Proc.Natl.Acad.Sci.USA, 106, 2009
3EQS
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BU of 3eqs by Molmil
Crystal structure of human MDM2 in complex with a 12-mer peptide inhibitor
Descriptor: 12-mer peptide inhibitor, E3 ubiquitin-protein ligase Mdm2, GUANIDINE
Authors:Pazgier, M, Lu, W.
Deposit date:2008-10-01
Release date:2009-03-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
Proc.Natl.Acad.Sci.USA, 106, 2009
4Z3S
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BU of 4z3s by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 3'-deoxy-3'-{[(2E)-3-(4-{[(4Z)-6-O-(6-deoxy-3,4-di-O-methyl-alpha-D-mannopyranosyl)-5-O-methyl-alpha-D-threo-hex-4-enofuranosyl]oxy}phenyl)-2-methylprop-2-enoyl]amino}-N,N-dimethyladenosine, ...
Authors:Polikanov, Y.S, Starosta, A.L, Juette, M.F, Altman, R.B, Terry, D.S, Lu, W, Burnett, B.J, Dinos, G, Reynolds, K, Blanchard, S.C, Steitz, T.A, Wilson, D.N.
Deposit date:2015-03-31
Release date:2015-06-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
2V5Y
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BU of 2v5y by Molmil
Crystal structure of the receptor protein tyrosine phosphatase mu ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE MU, SODIUM ION
Authors:Aricescu, A.R, Siebold, C, Choudhuri, K, Chang, V.T, Lu, W, Davis, S.J, van der Merwe, P.A, Jones, E.Y.
Deposit date:2007-07-11
Release date:2007-09-11
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of a Tyrosine Phosphatase Adhesive Interaction Reveals a Spacer-Clamp Mechanism.
Science, 317, 2007
1F3M
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BU of 1f3m by Molmil
CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1
Descriptor: IODIDE ION, SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA
Authors:Lei, M, Lu, W, Meng, W, Parrini, M.-C, Eck, M.J, Mayer, B.J, Harrison, S.C.
Deposit date:2000-06-05
Release date:2000-06-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.
Cell(Cambridge,Mass.), 102, 2000
2YGQ
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BU of 2ygq by Molmil
WIF domain-epidermal growth factor (EGF)-like domains 1-3 of human Wnt inhibitory factor 1 in complex with 1,2- dipalmitoylphosphatidylcholine
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Malinauskas, T, Aricescu, A.R, Lu, W, Siebold, C, Jones, E.Y.
Deposit date:2011-04-19
Release date:2011-07-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.951 Å)
Cite:Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1
Nat.Struct.Mol.Biol., 18, 2011
2YD9
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BU of 2yd9 by Molmil
Crystal structure of the N-terminal Ig1-3 module of Human Receptor Protein Tyrosine Phosphatase Sigma
Descriptor: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Coles, C.H, Shen, Y, Tenney, A.P, Siebold, C, Sutton, G.C, Lu, W, Gallagher, J.T, Jones, E.Y, Flanagan, J.G, Aricescu, A.R.
Deposit date:2011-03-18
Release date:2011-04-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Proteoglycan-Specific Molecular Switch for Rptp Sigma Clustering and Neuronal Extension.
Science, 332, 2011
2YGP
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BU of 2ygp by Molmil
WIF domain-EGF-like domain 1 Met77Trp of human Wnt inhibitory factor 1 in complex with 1,2-dipalmitoylphosphatidylcholine
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Malinauskas, T, Aricescu, A.R, Lu, W, Siebold, C, Jones, E.Y.
Deposit date:2011-04-19
Release date:2011-07-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.222 Å)
Cite:Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1
Nat.Struct.Mol.Biol., 18, 2011
2YD8
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BU of 2yd8 by Molmil
Crystal structure of the N-terminal Ig1-2 module of Human Receptor Protein Tyrosine Phosphatase LAR in complex with sucrose octasulphate
Descriptor: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE F
Authors:Coles, C.H, Shen, Y, Tenney, A.P, Siebold, C, Sutton, G.C, Lu, W, Gallagher, J.T, Jones, E.Y, Flanagan, J.G, Aricescu, A.R.
Deposit date:2011-03-18
Release date:2011-04-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Proteoglycan-Specific Molecular Switch for Rptp Sigma Clustering and Neuronal Extension.
Science, 332, 2011
2YGO
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BU of 2ygo by Molmil
WIF domain-EGF-like domain 1 of human Wnt inhibitory factor 1 in complex with 1,2-dipalmitoylphosphatidylcholine
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ...
Authors:Malinauskas, T, Aricescu, A.R, Lu, W, Siebold, C, Jones, E.Y.
Deposit date:2011-04-19
Release date:2011-07-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1
Nat.Struct.Mol.Biol., 18, 2011
2YD4
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BU of 2yd4 by Molmil
Crystal structure of the N-terminal Ig1-2 module of Chicken Receptor Protein Tyrosine Phosphatase Sigma
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, PROTEIN-TYROSINE PHOSPHATASE CRYPALPHA1 ISOFORM, ...
Authors:Coles, C.H, Shen, Y, Tenney, A.P, Siebold, C, Sutton, G.C, Lu, W, Gallagher, J.T, Jones, E.Y, Flanagan, J.G, Aricescu, A.R.
Deposit date:2011-03-17
Release date:2011-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Proteoglycan-Specific Molecular Switch for Rptp Sigma Clustering and Neuronal Extension.
Science, 332, 2011
2YGN
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BU of 2ygn by Molmil
WIF domain of human Wnt inhibitory factor 1 in complex with 1,2- dipalmitoylphosphatidylcholine
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ...
Authors:Malinauskas, T, Aricescu, A.R, Lu, W, Siebold, C, Jones, E.Y.
Deposit date:2011-04-19
Release date:2011-07-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1
Nat.Struct.Mol.Biol., 18, 2011
2YD5
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BU of 2yd5 by Molmil
Crystal structure of the N-terminal Ig1-2 module of Human Receptor Protein Tyrosine Phosphatase LAR
Descriptor: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE F
Authors:Coles, C.H, Shen, Y, Tenney, A.P, Siebold, C, Sutton, G.C, Lu, W, Gallagher, J.T, Jones, E.Y, Flanagan, J.G, Aricescu, A.R.
Deposit date:2011-03-17
Release date:2011-04-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Proteoglycan-Specific Molecular Switch for Rptp Sigma Clustering and Neuronal Extension.
Science, 332, 2011

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