4ADY
 
 | | Crystal structure of 26S proteasome subunit Rpn2 | | 分子名称: | 26S PROTEASOME REGULATORY SUBUNIT RPN2 | | 著者 | Kulkarni, K, He, J, Da Fonseca, P.C.A, Krutauz, D, Glickman, M.H, Barford, D, Morris, E.P. | | 登録日 | 2012-01-04 | | 公開日 | 2012-03-14 | | 最終更新日 | 2019-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The Structure of the 26S Proteasome Subunit Rpn2 Reveals its Pc Repeat Domain as a Closed Toroid of Two Concentric Alpha-Helical Rings
Structure, 20, 2012
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4CAD
 | | Mechanism of farnesylated CAAX protein processing by the integral membrane protease Rce1 | | 分子名称: | ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, DODECYL-BETA-D-MALTOSIDE, ... | | 著者 | Kulkarni, K, Manolaridis, I, Dodd, R.B, Cronin, N, Ogasawara, S, Iwata, S, Barford, D. | | 登録日 | 2013-10-08 | | 公開日 | 2013-11-27 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mechanism of Farnesylated Caax Protein Processing by the Intramembrane Protease Rce1
Nature, 504, 2013
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5BPW
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1NXU
 | | CRYSTAL STRUCTURE OF E. COLI HYPOTHETICAL OXIDOREDUCTASE YIAK NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ER82. | | 分子名称: | Hypothetical oxidoreductase yiaK, SULFATE ION | | 著者 | Forouhar, F, Lee, I, Benach, J, Kulkarni, K, Xiao, R, Acton, T.B, Shastry, R, Rost, B, Montelione, G.T, Tong, L, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2003-02-11 | | 公開日 | 2003-03-11 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A Novel NAD-binding Protein Revealed by the Crystal Structure of 2,3-Diketo-L-gulonate Reductase (YiaK).
J.Biol.Chem., 279, 2004
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1S20
 | | A novel NAD binding protein revealed by the crystal structure of E. Coli 2,3-diketogulonate reductase (YiaK) NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ER82 | | 分子名称: | Hypothetical oxidoreductase yiaK, L(+)-TARTARIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Forouhar, F, Lee, I, Benach, J, Kulkarni, K, Xiao, R, Acton, T.B, Montelione, G.T, Tong, L, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2004-01-07 | | 公開日 | 2004-01-20 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | A Novel NAD-binding Protein Revealed by the Crystal Structure of 2,3-Diketo-L-gulonate Reductase (YiaK).
J.Biol.Chem., 279, 2004
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4A2N
 | | Crystal Structure of Ma-ICMT | | 分子名称: | CARDIOLIPIN, ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE, PALMITIC ACID, ... | | 著者 | Yang, J, Kulkarni, K, Manolaridis, I, Zhang, Z, Dodd, R.B, Mas-Droux, C, Barford, D. | | 登録日 | 2011-09-27 | | 公開日 | 2012-01-11 | | 最終更新日 | 2018-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Mechanism of Isoprenylcysteine Carboxyl Methylation from the Crystal Structure of the Integral Membrane Methyltransferase Icmt.
Mol.Cell, 44, 2011
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6A8M
 | | N-terminal domain of FACT complex subunit SPT16 from Eremothecium gossypii (Ashbya gossypii) | | 分子名称: | FACT complex subunit SPT16 | | 著者 | Gaur, N.K, Are, V.N, Durani, V, Ghosh, B, Kumar, A, Kulkarni, K, Makde, R.D. | | 登録日 | 2018-07-09 | | 公開日 | 2018-08-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Evolutionary conservation of protein dynamics: insights from all-atom molecular dynamics simulations of 'peptidase' domain of Spt16.
J.Biomol.Struct.Dyn., 2021
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2YIN
 | | STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1. | | 分子名称: | DEDICATOR OF CYTOKINESIS PROTEIN 2, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1 | | 著者 | Kulkarni, K.A, Yang, J, Zhang, Z, Barford, D. | | 登録日 | 2011-05-16 | | 公開日 | 2011-05-25 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (Dock) Nucleotide Exchange Factors.
J.Biol.Chem., 286, 2011
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6K3G
 | | Crystal structure of 10-Hydroxygeraniol Dehydrogenase from Cantharanthus roseus in complex with NADP+ | | 分子名称: | 10-hydroxygeraniol oxidoreductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ZINC ION | | 著者 | Sandholu, A.S, Sharmila, P.M, Thulasiram, H.V, Kulkarni, K.A. | | 登録日 | 2019-05-18 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Structural studies on 10-hydroxygeraniol dehydrogenase: A novel linear substrate-specific dehydrogenase from Catharanthus roseus.
Proteins, 88, 2020
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6KJ5
 | | Crystal structure of 10-Hydroxygeraniol Dehydrogenase apo form from Cantharanthus roseus | | 分子名称: | 10-hydroxygeraniol dehydrogenase, ZINC ION | | 著者 | Sandholu, A.S, Sharmila, P.M, Thulasiram, H.V, Kulkarni, K.A. | | 登録日 | 2019-07-21 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.75 Å) | | 主引用文献 | Structural studies on 10-hydroxygeraniol dehydrogenase: A novel linear substrate-specific dehydrogenase from Catharanthus roseus.
Proteins, 88, 2020
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6K16
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5U06
 | | Grb7-SH2 with bicyclic peptide inhibitor containing a pY mimetic | | 分子名称: | Growth factor receptor-bound protein 7, POTASSIUM ION, bicyclic peptide inhibitor: LYS-PHE-GLU-GLY-CMF-ASP-ASN-GLU-CST | | 著者 | Watson, G.M, Wilce, J.A. | | 登録日 | 2016-11-22 | | 公開日 | 2017-11-15 | | 最終更新日 | 2020-01-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.
J. Med. Chem., 60, 2017
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5TYI
 | | Grb7 SH2 with bicyclic peptide containing pY mimetic | | 分子名称: | Growth factor receptor-bound protein 7, Peptide inhibitor | | 著者 | Watson, G.M, Wilce, M.C.J, Wilce, J.A. | | 登録日 | 2016-11-20 | | 公開日 | 2017-11-15 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.
J. Med. Chem., 60, 2017
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5U1Q
 | | Grb7-SH2 with bicyclic peptide inhibitor | | 分子名称: | CHLORIDE ION, Growth factor receptor-bound protein 7, LYS-PHE-GLU-GLY-TYR-ASP-ASN-GLU-CST | | 著者 | Watson, G.M, Wilce, M.C.J, Wilce, J.A. | | 登録日 | 2016-11-28 | | 公開日 | 2017-11-15 | | 最終更新日 | 2020-01-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.
J. Med. Chem., 60, 2017
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5EMH
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4WWQ
 | | Apo structure of the Grb7 SH2 domain | | 分子名称: | Growth factor receptor-bound protein 7, MALONIC ACID | | 著者 | Watson, G.M, Ambaye, N.D, Wilce, M.C, Wilce, J.A. | | 登録日 | 2014-11-12 | | 公開日 | 2015-09-23 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
J.Med.Chem., 58, 2015
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4X6S
 | | Grb7 SH2 domain with phosphotyrosine mimetic inhibitor peptide | | 分子名称: | Growth factor receptor-bound protein 7, Phosphotyrosine mimetic inhibitor peptide G7-TEM1 | | 著者 | Watson, G.M, Panjikar, S, Wilce, M.C, Wilce, J.A. | | 登録日 | 2014-12-09 | | 公開日 | 2015-09-23 | | 最終更新日 | 2015-10-28 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
J.Med.Chem., 58, 2015
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3ZN3
 | | N-terminal domain of S. pombe Cdc23 APC subunit | | 分子名称: | ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, MERCURY (II) ION | | 著者 | Zhang, Z, Yang, J, Conin, N, Kulkarni, K, Barford, D. | | 登録日 | 2013-02-13 | | 公開日 | 2013-02-20 | | 最終更新日 | 2019-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Four Canonical Tpr Subunits of Human Apc/C Form Related Homo-Dimeric Structures and Stack in Parallel to Form a Tpr Suprahelix
J.Mol.Biol., 425, 2013
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5BPT
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5BPZ
 | | Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain | | 分子名称: | 1,2-ETHANEDIOL, Anapc5 protein | | 著者 | Cronin, N, Yang, J, Zhang, Z, Barford, D. | | 登録日 | 2015-05-28 | | 公開日 | 2015-09-02 | | 最終更新日 | 2015-10-07 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.
J.Mol.Biol., 427, 2015
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5D0J
 | | Grb7 SH2 with inhibitor peptide | | 分子名称: | G7-TEdFP peptide, Growth factor receptor-bound protein 7, PHOSPHATE ION | | 著者 | Gunzburg, M.J, Watson, G.M, Wilce, J.A, Wilce, M.C.J. | | 登録日 | 2015-08-03 | | 公開日 | 2016-06-15 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Sci Rep, 6, 2016
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5EEQ
 | | Grb7 SH2 with the G7-B1 bicyclic peptide inhibitor | | 分子名称: | Bicyclic Peptide Inhibitor, Growth factor receptor-bound protein 7, PHOSPHATE ION | | 著者 | Ambaye, N.D, Watson, G.M, Wilce, M.C.J, Wilce, G.M. | | 登録日 | 2015-10-23 | | 公開日 | 2016-06-15 | | 最終更新日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Sci Rep, 6, 2016
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5EEL
 | | Grb7 SH2 with bicyclic peptide inhibitor | | 分子名称: | Bicyclic Peptide Inhibitor, FORMIC ACID, Growth factor receptor-bound protein 7, ... | | 著者 | Watson, G.M, Gunzburg, M.J, Wilce, M.C.J, Wilce, J.A. | | 登録日 | 2015-10-23 | | 公開日 | 2016-06-15 | | 最終更新日 | 2018-12-26 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Sci Rep, 6, 2016
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