5EEQ

Grb7 SH2 with the G7-B1 bicyclic peptide inhibitor

Summary for 5EEQ

• Entry DOI: 10.2210/pdb5eeq/pdb
• Related: 5EEL
• Descriptor: Growth factor receptor-bound protein 7, Bicyclic Peptide Inhibitor, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: staple, sh2, inhibitor, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm : Q14451
• Total number of polymer chains: 4
• Total formula weight: 30328.29

Authors

Ambaye, N.D.,Watson, G.M.,Wilce, M.C.J.,Wilce, G.M. (deposition date: 2015-10-23, release date: 2016-06-15, Last modification date: 2024-04-17)

• Primary citation: Gunzburg, M.J.,Kulkarni, K.,Watson, G.M.,Ambaye, N.D.,Del Borgo, M.P.,Brandt, R.,Pero, S.C.,Perlmutter, P.,Wilce, M.C.,Wilce, J.A.; Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.; Sci Rep, 6:27060-27060, 2016; PubMed: 27257138; DOI: 10.1038/srep27060

Experimental method

X-RAY DIFFRACTION (1.6 Å)