5TYI
Grb7 SH2 with bicyclic peptide containing pY mimetic
Summary for 5TYI
Entry DOI | 10.2210/pdb5tyi/pdb |
Related | 5U06 5U1Q |
Descriptor | Growth factor receptor-bound protein 7, Peptide inhibitor (3 entities in total) |
Functional Keywords | sh2, inhibitor, bicyclic, signaling protein-peptide complex, signaling protein/peptide |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 59523.71 |
Authors | Watson, G.M.,Wilce, M.C.J.,Wilce, J.A. (deposition date: 2016-11-20, release date: 2017-11-15, Last modification date: 2023-11-15) |
Primary citation | Watson, G.M.,Kulkarni, K.,Sang, J.,Ma, X.,Gunzburg, M.J.,Perlmutter, P.,Wilce, M.C.J.,Wilce, J.A. Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J. Med. Chem., 60:9349-9359, 2017 Cited by PubMed: 29083893DOI: 10.1021/acs.jmedchem.7b01320 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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