4X6S

Grb7 SH2 domain with phosphotyrosine mimetic inhibitor peptide

Summary for 4X6S

Entry DOI	10.2210/pdb4x6s/pdb
Descriptor	Growth factor receptor-bound protein 7, Phosphotyrosine mimetic inhibitor peptide G7-TEM1 (3 entities in total)
Functional Keywords	src homology domain, inhibitor, phosphotyrosine binding pocket, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm: Q14451
Total number of polymer chains	4
Total formula weight	28080.05
Authors	Watson, G.M.,Panjikar, S.,Wilce, M.C.,Wilce, J.A. (deposition date: 2014-12-09, release date: 2015-09-23, Last modification date: 2015-10-28)
Primary citation	Watson, G.M.,Gunzburg, M.J.,Ambaye, N.D.,Lucas, W.A.,Traore, D.A.,Kulkarni, K.,Cergol, K.M.,Payne, R.J.,Panjikar, S.,Pero, S.C.,Perlmutter, P.,Wilce, M.C.,Wilce, J.A. Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J.Med.Chem., 58:7707-7718, 2015 Cited by PubMed: 26359549 DOI: 10.1021/acs.jmedchem.5b00609 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation