5D0J

Grb7 SH2 with inhibitor peptide

Summary for 5D0J

• Entry DOI: 10.2210/pdb5d0j/pdb
• Descriptor: Growth factor receptor-bound protein 7, G7-TEdFP peptide, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: inhibitor, sh2, signaling protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : Q14451
• Total number of polymer chains: 6
• Total formula weight: 56994.82

Authors

Gunzburg, M.J.,Watson, G.M.,Wilce, J.A.,Wilce, M.C.J. (deposition date: 2015-08-03, release date: 2016-06-15, Last modification date: 2023-09-27)

• Primary citation: Gunzburg, M.J.,Kulkarni, K.,Watson, G.M.,Ambaye, N.D.,Del Borgo, M.P.,Brandt, R.,Pero, S.C.,Perlmutter, P.,Wilce, M.C.,Wilce, J.A.; Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.; Sci Rep, 6:27060-27060, 2016; PubMed: 27257138; DOI: 10.1038/srep27060

Experimental method

X-RAY DIFFRACTION (2.6 Å)