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4WWQ

Apo structure of the Grb7 SH2 domain

Summary for 4WWQ
Entry DOI10.2210/pdb4wwq/pdb
DescriptorGrowth factor receptor-bound protein 7, MALONIC ACID (3 entities in total)
Functional Keywordssrc homology domain, phosphotyrosine binding pocket, signaling protein
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : Q14451
Total number of polymer chains2
Total formula weight27485.48
Authors
Watson, G.M.,Ambaye, N.D.,Wilce, M.C.,Wilce, J.A. (deposition date: 2014-11-12, release date: 2015-09-23, Last modification date: 2023-09-27)
Primary citationWatson, G.M.,Gunzburg, M.J.,Ambaye, N.D.,Lucas, W.A.,Traore, D.A.,Kulkarni, K.,Cergol, K.M.,Payne, R.J.,Panjikar, S.,Pero, S.C.,Perlmutter, P.,Wilce, M.C.,Wilce, J.A.
Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
J.Med.Chem., 58:7707-7718, 2015
Cited by
PubMed: 26359549
DOI: 10.1021/acs.jmedchem.5b00609
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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