5CQQ
 
 | | Crystal structure of the Drosophila Zeste DNA binding domain in complex with DNA | | Descriptor: | DNA (5'-D(*AP*AP*AP*AP*AP*CP*GP*AP*GP*TP*GP*GP*AP*AP*AP*AP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*TP*TP*TP*TP*CP*CP*AP*CP*TP*CP*GP*TP*TP*TP*TP*T)-3'), Regulatory protein zeste | | Authors: | Gao, G.N, Wang, M, Yang, N, Huang, Y, Xu, R.M. | | Deposit date: | 2015-07-22 | | Release date: | 2015-11-04 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure of Zeste-DNA Complex Reveals a New Modality of DNA Recognition by Homeodomain-Like Proteins
J.Mol.Biol., 427, 2015
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7CYQ
 | | Cryo-EM structure of an extended SARS-CoV-2 replication and transcription complex reveals an intermediate state in cap synthesis | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Helicase, MAGNESIUM ION, ... | | Authors: | Yan, L, Ge, J, Zheng, L, Zhang, Y, Gao, Y, Wang, T, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. | | Deposit date: | 2020-09-04 | | Release date: | 2020-12-09 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.83 Å) | | Cite: | Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis.
Cell, 184, 2021
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2QC3
 | | Crystal structure of MCAT from Mycobacterium tuberculosis | | Descriptor: | ACETIC ACID, Malonyl CoA-acyl carrier protein transacylase | | Authors: | Li, Z, Huang, Y, Ge, J, Bartlam, M, Wang, H, Rao, Z. | | Deposit date: | 2007-06-19 | | Release date: | 2007-08-28 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The Crystal Structure of MCAT from Mycobacterium tuberculosis Reveals Three New Catalytic Models.
J.Mol.Biol., 371, 2007
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2KD0
 | | NMR solution structure of O64736 protein from Arabidopsis thaliana. Northeast Structural Genomics Consortium MEGA Target AR3445A | | Descriptor: | LRR repeats and ubiquitin-like domain-containing protein At2g30105 | | Authors: | Swapna, G.V.T, Shastry, R, Foote, E, Ciccosanti, C, Jiang, M, Xiao, R, Nair, R, Everett, J, Huang, Y, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2008-12-31 | | Release date: | 2009-02-10 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | NMR solution structure of O64736 protein from Arabidopsis thaliana
To be Published
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2KK8
 | | NMR Solution Structure of a Putative Uncharacterized Protein obtained from Arabidopsis thaliana: Northeast Structural Genomics Consortium target AR3449A | | Descriptor: | Uncharacterized protein AT4g05270 | | Authors: | Mani, R, Gurla, S.V.T, Shastry, R, Ciccosanti, C, Foote, E, Jiang, M, Xiao, R, Nair, R, Everett, J, Huang, Y, Acton, T, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2009-06-16 | | Release date: | 2009-06-30 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | NMR Solution Structure of a Putative Uncharacterized Protein obtained from Arabidopsis thaliana: Northeast Structural Genomics Consortium Target AR3449A
To be Published
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2KRT
 | | Solution NMR Structure of a Conserved Hypothetical Membrane Lipoprotein Obtained from Ureaplasma parvum: Northeast Structural Genomics Consortium Target UuR17A (139-239) | | Descriptor: | Conserved hypothetical membrane lipoprotein | | Authors: | Mani, R, Swapna, G, Janjua, H, Ciccosanti, C, Huang, Y, Patel, D, Xiao, R, Acton, T, Everett, J, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2009-12-22 | | Release date: | 2010-01-05 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | NMR Solution Structure of a Conserved Hypothetical Membrane Lipoprotein obtained from Ureaplasma parvum : Northeast Structural Genomics Consortium Target UuR17A (139-239)
To be Published
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2KPW
 | | NMR solution structure of Lamin-B1 protein from Homo sapiens: Northeast Structural Genomics Consortium MEGA target, HR5546A (439-549) | | Descriptor: | Lamin-B1 | | Authors: | Swapna, G.V.T, Ciccosanti, C.L, Belote, R, Hamilton, K, Acton, T, Huang, Y, Xiao, R, Everett, J, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2009-10-21 | | Release date: | 2009-11-10 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | NMR solution structure of Lamin-B1 protein from Homo sapiens: Northeast Structural Genomics Consortium target, HR5546A (439-549)
To be Published
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7BTF
 | | SARS-CoV-2 RNA-dependent RNA polymerase in complex with cofactors in reduced condition | | Descriptor: | Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ... | | Authors: | Gao, Y, Yan, L, Huang, Y, Liu, F, Cao, L, Wang, T, Wang, Q, Lou, Z, Rao, Z. | | Deposit date: | 2020-04-01 | | Release date: | 2020-04-08 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Science, 368, 2020
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8H4R
 | | The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, G1/S-specific cyclin-E1, ... | | Authors: | Gui, W, Wang, F, Cheng, W, Gao, J, Huang, Y, Ouyang, Z. | | Deposit date: | 2022-10-11 | | Release date: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus
To Be Published
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8IA5
 | | Small peptide enhances the binding of nutline-3a to N-terminal domain of MdmX | | Descriptor: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, 9-mer peptide, ... | | Authors: | Cheng, X.Y, Wei, Q.Y, Huang, Y, Su, Z.D. | | Deposit date: | 2023-02-07 | | Release date: | 2023-02-22 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Small peptide enhances the binding of nutline-3a to N-terminal domain of MdmX
To Be Published
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7WZ6
 | | Crystal structure of MyoD-E47 | | Descriptor: | Isoform E47 of Transcription factor E2-alpha, Myoblast determination protein 1 | | Authors: | Zhong, J, Huang, Y, Ma, J. | | Deposit date: | 2022-02-17 | | Release date: | 2022-06-22 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural basis of the bHLH domains of MyoD-E47 heterodimer.
Biochem.Biophys.Res.Commun., 621, 2022
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8IZ7
 | | cryo-EM structure of sulindac-bound hMRP4 | | Descriptor: | ATP-binding cassette sub-family C member 4, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid | | Authors: | Liu, Z.M, Huang, Y. | | Deposit date: | 2023-04-06 | | Release date: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | cryo-EM structure of sulindac-bound hMRP4
To Be Published
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8IZ8
 | | cryo EM structure of apo hMRP4 | | Descriptor: | ATP-binding cassette sub-family C member 4 | | Authors: | Liu, Z.M, Huang, Y. | | Deposit date: | 2023-04-06 | | Release date: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.13 Å) | | Cite: | cryo EM structure of apo hMRP4
To Be Published
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8IZA
 | | cryo-EM structure of ATP-bound hMRP4 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 4, MAGNESIUM ION | | Authors: | Liu, Z.M, Huang, Y. | | Deposit date: | 2023-04-06 | | Release date: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | cryo-EM structure of ATP-bound hMRP4
To Be Published
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8IZ9
 | | cryo-EM structure of PGE1-bound hMRP4 | | Descriptor: | 7-[(1R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]heptanoic acid, ATP-binding cassette sub-family C member 4 | | Authors: | Liu, Z.M, Huang, Y. | | Deposit date: | 2023-04-06 | | Release date: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | cryo-EM structure of PGE1-bound hMRP4
To Be Published
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7CXN
 | | Architecture of a SARS-CoV-2 mini replication and transcription complex | | Descriptor: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | | Authors: | Yan, L, Zhang, Y, Ge, J, Zheng, L, Gao, Y, Wang, T, Jia, Z, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. | | Deposit date: | 2020-09-02 | | Release date: | 2020-11-04 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.84 Å) | | Cite: | Architecture of a SARS-CoV-2 mini replication and transcription complex.
Nat Commun, 11, 2020
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7CXM
 | | Architecture of a SARS-CoV-2 mini replication and transcription complex | | Descriptor: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | | Authors: | Yan, L, Zhang, Y, Ge, J, Zheng, L, Gao, Y, Wang, T, Jia, Z, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. | | Deposit date: | 2020-09-02 | | Release date: | 2020-11-04 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Architecture of a SARS-CoV-2 mini replication and transcription complex.
Nat Commun, 11, 2020
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5YGF
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5YGD
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5YGB
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5YGC
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7Y1Q
 | | 5.0 angstrom cryo-EM structure of transmembrane regions of mouse Basigin/MCT1 in complex with antibody 6E7F1 | | Descriptor: | Isoform 2 of Basigin, Monocarboxylate transporter 1 | | Authors: | Zhang, H, Yang, X, Xue, Y, Huang, Y, Mo, X, Zhang, H, Li, N, Gao, N, Li, X, Wang, S, Gao, Y, Liao, J. | | Deposit date: | 2022-06-08 | | Release date: | 2023-06-14 | | Method: | ELECTRON MICROSCOPY (5.03 Å) | | Cite: | Allosteric modulation of monocarboxylate transporters 1 and 4 by targeting their chaperon Basigin-2
To Be Published
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7Y1B
 | | 3.2 angstrom cryo-EM structure of extracellular region of mouse Basigin-2 in complex with the Fab fragment of antibody 6E7F1 | | Descriptor: | Heavy chain of 6E7F1, Isoform 2 of Basigin, Light chain of 6E7F1 | | Authors: | Zhang, H, Yang, X, Xue, Y, Huang, Y, Mo, X, Zhang, H, Li, N, Gao, N, Li, X, Wang, S, Gao, Y, Liao, J. | | Deposit date: | 2022-06-08 | | Release date: | 2023-06-14 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Allosteric modulation of monocarboxylate transporters 1 and 4 by targeting their chaperon Basigin
To Be Published
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6KG6
 | | Crystal structure of MavC/UBE2N-Ub complex | | Descriptor: | MavC, Ubiquitin-40S ribosomal protein S27a, Ubiquitin-conjugating enzyme E2 N | | Authors: | Wang, Y, Huang, Y, Chang, M, Feng, Y. | | Deposit date: | 2019-07-10 | | Release date: | 2020-04-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC.
Nat Commun, 11, 2020
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7WJV
 | | Crystal structure of human liver FBPase complexed with an covalent inhibitor | | Descriptor: | 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, ... | | Authors: | Cao, H, Huang, Y, Ren, Y, Wan, J. | | Deposit date: | 2022-01-08 | | Release date: | 2022-07-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.724 Å) | | Cite: | N -Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction.
J.Med.Chem., 65, 2022
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