6UZG
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6VAM
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6UZR
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6UZW
| Crystal structure of GLUN1/GLUN2A ligand-binding domain in complex with glycine and UBP791 | Descriptor: | (2S,3R)-1-[7-(2-carboxyethyl)phenanthrene-2-carbonyl]piperazine-2,3-dicarboxylic acid, GLYCINE, Glutamate receptor ionotropic, ... | Authors: | Wang, J.X, Furukawa, H. | Deposit date: | 2019-11-15 | Release date: | 2020-01-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors. Nat Commun, 11, 2020
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6VD7
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6VAK
| Cryo-EM structure of human CALHM2 | Descriptor: | Calcium homeostasis modulator protein 2 | Authors: | Syrjanen, J.L, Chou, T.H, Furukawa, H. | Deposit date: | 2019-12-17 | Release date: | 2020-01-29 | Last modified: | 2020-02-26 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Structure and assembly of calcium homeostasis modulator proteins. Nat.Struct.Mol.Biol., 27, 2020
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7SAB
| Phencyclidine-bound GluN1a-GluN2B NMDA receptors | Descriptor: | 1-(PHENYL-1-CYCLOHEXYL)PIPERIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chou, T.-H, Furukawa, H. | Deposit date: | 2021-09-22 | Release date: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural insights into binding of therapeutic channel blockers in NMDA receptors. Nat.Struct.Mol.Biol., 29, 2022
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7SAD
| Memantine-bound GluN1a-GluN2B NMDA receptors | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | Authors: | Chou, T.-H, Furukawa, H. | Deposit date: | 2021-09-22 | Release date: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (3.96 Å) | Cite: | Structural insights into binding of therapeutic channel blockers in NMDA receptors. Nat.Struct.Mol.Biol., 29, 2022
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7SAC
| S-(+)-ketamine bound GluN1a-GluN2B NMDA receptors at 3.69 Angstrom resolution | Descriptor: | (2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chou, T.-H, Furukawa, H. | Deposit date: | 2021-09-22 | Release date: | 2022-07-20 | Last modified: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3.69 Å) | Cite: | Structural insights into binding of therapeutic channel blockers in NMDA receptors. Nat.Struct.Mol.Biol., 29, 2022
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7SAA
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4NF6
| Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and PPDA | Descriptor: | (2S,3R)-1-(phenanthren-2-ylcarbonyl)piperazine-2,3-dicarboxylic acid, GLYCINE, Glutamate receptor ionotropic, ... | Authors: | Jespersen, A, Tajima, N, Furukawa, H. | Deposit date: | 2013-10-30 | Release date: | 2014-03-12 | Last modified: | 2017-08-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
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4NF8
| Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and glutamate in PEG2000MME | Descriptor: | GLUTAMIC ACID, GLYCINE, Glutamate receptor ionotropic, ... | Authors: | Jespersen, A, Tajima, N, Furukawa, H. | Deposit date: | 2013-10-30 | Release date: | 2014-03-12 | Last modified: | 2017-08-09 | Method: | X-RAY DIFFRACTION (1.856 Å) | Cite: | Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
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4NF4
| Crystal structure of GluN1/GluN2A ligand-binding domain in complex with DCKA and glutamate | Descriptor: | 4-hydroxy-5,7-dimethylquinoline-2-carboxylic acid, GLUTAMIC ACID, Glutamate receptor ionotropic, ... | Authors: | Annie, J, Tajima, N, Furukawa, H. | Deposit date: | 2013-10-30 | Release date: | 2014-03-12 | Last modified: | 2017-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
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4NF5
| Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and D-AP5 | Descriptor: | 5-phosphono-D-norvaline, GLYCEROL, GLYCINE, ... | Authors: | Jespersen, A, Tajima, N, Furukawa, H. | Deposit date: | 2013-10-30 | Release date: | 2014-03-12 | Last modified: | 2017-08-09 | Method: | X-RAY DIFFRACTION (1.903 Å) | Cite: | Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
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4PE5
| Crystal Structure of GluN1a/GluN2B NMDA Receptor Ion Channel | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol, ... | Authors: | Karakas, E, Furukawa, H. | Deposit date: | 2014-04-22 | Release date: | 2014-06-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.96 Å) | Cite: | Crystal structure of a heterotetrameric NMDA receptor ion channel. Science, 344, 2014
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5FXI
| GluN1b-GluN2B NMDA receptor structure in non-active-2 conformation | Descriptor: | N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B | Authors: | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. | Deposit date: | 2016-03-02 | Release date: | 2016-05-11 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
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5FXK
| GluN1b-GluN2B NMDA receptor structure-Class Y | Descriptor: | N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B | Authors: | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. | Deposit date: | 2016-03-02 | Release date: | 2016-05-11 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
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5FXG
| GLUN1B-GLUN2B NMDA RECEPTOR IN ACTIVE CONFORMATION | Descriptor: | N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B | Authors: | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. | Deposit date: | 2016-03-02 | Release date: | 2016-05-11 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (6.8 Å) | Cite: | Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
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5FXH
| GluN1b-GluN2B NMDA receptor in non-active-1 conformation | Descriptor: | N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B | Authors: | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. | Deposit date: | 2016-03-02 | Release date: | 2016-05-11 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
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5FXJ
| GluN1b-GluN2B NMDA receptor structure-Class X | Descriptor: | GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1, NMDA 2B | Authors: | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa H, H. | Deposit date: | 2016-03-02 | Release date: | 2016-05-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (6.25 Å) | Cite: | Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
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5OJK
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5OJ2
| Crystal structure of the chicken MDGA1 ectodomain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAM domain-containing glycosylphosphatidylinositol anchor protein 1, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Elegheert, J, Clayton, A.J, Aricescu, A.R. | Deposit date: | 2017-07-20 | Release date: | 2017-08-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins. Neuron, 95, 2017
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5OJ6
| Crystal structure of the chicken MDGA1 ectodomain in complex with the human neuroligin 1 (NL1(-A-B)) cholinesterase domain. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAM domain-containing glycosylphosphatidylinositol anchor protein 1, Neuroligin-1, ... | Authors: | Elegheert, J, Clayton, A.J, Aricescu, A.R. | Deposit date: | 2017-07-20 | Release date: | 2017-08-23 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins. Neuron, 95, 2017
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4KFQ
| Crystal structure of the NMDA receptor GluN1 ligand binding domain in complex with 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one | Descriptor: | 1-sulfanyl[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one, GLYCEROL, Glutamate receptor ionotropic, ... | Authors: | Steffensen, T.B, Tabrizi, F.M, Gajhede, M, Kastrup, J.S. | Deposit date: | 2013-04-27 | Release date: | 2013-10-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. J.Biol.Chem., 288, 2013
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8IE2
| Crystal structure of Lactiplantibacillus plantarum GlyRS | Descriptor: | Glycine--tRNA ligase alpha subunit, Glycine--tRNA ligase beta subunit | Authors: | Yamashita, S, Tomita, K. | Deposit date: | 2023-02-15 | Release date: | 2023-06-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Mechanism of tRNA recognition by heterotetrameric glycyl-tRNA synthetase from lactic acid bacteria. J.Biochem., 174, 2023
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