5OJ6

Crystal structure of the chicken MDGA1 ectodomain in complex with the human neuroligin 1 (NL1(-A-B)) cholinesterase domain.

Summary for 5OJ6

• Entry DOI: 10.2210/pdb5oj6/pdb
• Descriptor: Neuroligin-1, MAM domain-containing glycosylphosphatidylinositol anchor protein 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: neuroligin-neurexin, synapse formation, austism spectrum disorders (asds), synaptic transmission, cell adhesion
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 168897.33

Authors

Elegheert, J.,Clayton, A.J.,Aricescu, A.R. (deposition date: 2017-07-20, release date: 2017-08-23, Last modification date: 2024-01-17)

• Primary citation: Elegheert, J.,Cvetkovska, V.,Clayton, A.J.,Heroven, C.,Vennekens, K.M.,Smukowski, S.N.,Regan, M.C.,Jia, W.,Smith, A.C.,Furukawa, H.,Savas, J.N.,de Wit, J.,Begbie, J.,Craig, A.M.,Aricescu, A.R.; Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins.; Neuron, 95:896-913.e10, 2017; PubMed: 28817804; DOI: 10.1016/j.neuron.2017.07.040

Experimental method

X-RAY DIFFRACTION (3.3 Å)