6UZG

Crystal structure of GLUN1/GLUN2A-4M mutant ligand-binding domain in complex with glycine and homoquinolinic acid

Summary for 6UZG

Entry DOI	10.2210/pdb6uzg/pdb
Descriptor	Glutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 2A, GLYCINE, ... (5 entities in total)
Functional Keywords	nmdar, ligand-binding domain, agonist, membrane protein
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	2
Total formula weight	65454.73
Authors	Wang, J.X.,Furukawa, H. (deposition date: 2019-11-15, release date: 2020-01-29, Last modification date: 2023-10-11)
Primary citation	Wang, J.X.,Irvine, M.W.,Burnell, E.S.,Sapkota, K.,Thatcher, R.J.,Li, M.,Simorowski, N.,Volianskis, A.,Collingridge, G.L.,Monaghan, D.T.,Jane, D.E.,Furukawa, H. Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors. Nat Commun, 11:423-423, 2020 Cited by PubMed: 31969570 DOI: 10.1038/s41467-020-14321-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation