6UZG
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6VAM
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6UZR
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6UZW
| Crystal structure of GLUN1/GLUN2A ligand-binding domain in complex with glycine and UBP791 | 分子名称: | (2S,3R)-1-[7-(2-carboxyethyl)phenanthrene-2-carbonyl]piperazine-2,3-dicarboxylic acid, GLYCINE, Glutamate receptor ionotropic, ... | 著者 | Wang, J.X, Furukawa, H. | 登録日 | 2019-11-15 | 公開日 | 2020-01-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors. Nat Commun, 11, 2020
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6VD7
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6VAK
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7SAB
| Phencyclidine-bound GluN1a-GluN2B NMDA receptors | 分子名称: | 1-(PHENYL-1-CYCLOHEXYL)PIPERIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Chou, T.-H, Furukawa, H. | 登録日 | 2021-09-22 | 公開日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural insights into binding of therapeutic channel blockers in NMDA receptors. Nat.Struct.Mol.Biol., 29, 2022
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7SAD
| Memantine-bound GluN1a-GluN2B NMDA receptors | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Chou, T.-H, Furukawa, H. | 登録日 | 2021-09-22 | 公開日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | 主引用文献 | Structural insights into binding of therapeutic channel blockers in NMDA receptors. Nat.Struct.Mol.Biol., 29, 2022
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7SAC
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7SAA
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4NF6
| Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and PPDA | 分子名称: | (2S,3R)-1-(phenanthren-2-ylcarbonyl)piperazine-2,3-dicarboxylic acid, GLYCINE, Glutamate receptor ionotropic, ... | 著者 | Jespersen, A, Tajima, N, Furukawa, H. | 登録日 | 2013-10-30 | 公開日 | 2014-03-12 | 最終更新日 | 2017-08-09 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
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4NF8
| Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and glutamate in PEG2000MME | 分子名称: | GLUTAMIC ACID, GLYCINE, Glutamate receptor ionotropic, ... | 著者 | Jespersen, A, Tajima, N, Furukawa, H. | 登録日 | 2013-10-30 | 公開日 | 2014-03-12 | 最終更新日 | 2017-08-09 | 実験手法 | X-RAY DIFFRACTION (1.856 Å) | 主引用文献 | Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
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4NF4
| Crystal structure of GluN1/GluN2A ligand-binding domain in complex with DCKA and glutamate | 分子名称: | 4-hydroxy-5,7-dimethylquinoline-2-carboxylic acid, GLUTAMIC ACID, Glutamate receptor ionotropic, ... | 著者 | Annie, J, Tajima, N, Furukawa, H. | 登録日 | 2013-10-30 | 公開日 | 2014-03-12 | 最終更新日 | 2017-08-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
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4NF5
| Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and D-AP5 | 分子名称: | 5-phosphono-D-norvaline, GLYCEROL, GLYCINE, ... | 著者 | Jespersen, A, Tajima, N, Furukawa, H. | 登録日 | 2013-10-30 | 公開日 | 2014-03-12 | 最終更新日 | 2017-08-09 | 実験手法 | X-RAY DIFFRACTION (1.903 Å) | 主引用文献 | Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
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4PE5
| Crystal Structure of GluN1a/GluN2B NMDA Receptor Ion Channel | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol, ... | 著者 | Karakas, E, Furukawa, H. | 登録日 | 2014-04-22 | 公開日 | 2014-06-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.96 Å) | 主引用文献 | Crystal structure of a heterotetrameric NMDA receptor ion channel. Science, 344, 2014
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5FXI
| GluN1b-GluN2B NMDA receptor structure in non-active-2 conformation | 分子名称: | N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B | 著者 | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. | 登録日 | 2016-03-02 | 公開日 | 2016-05-11 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | 主引用文献 | Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
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5FXK
| GluN1b-GluN2B NMDA receptor structure-Class Y | 分子名称: | N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B | 著者 | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. | 登録日 | 2016-03-02 | 公開日 | 2016-05-11 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | 主引用文献 | Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
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5FXG
| GLUN1B-GLUN2B NMDA RECEPTOR IN ACTIVE CONFORMATION | 分子名称: | N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B | 著者 | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. | 登録日 | 2016-03-02 | 公開日 | 2016-05-11 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (6.8 Å) | 主引用文献 | Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
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5FXH
| GluN1b-GluN2B NMDA receptor in non-active-1 conformation | 分子名称: | N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B | 著者 | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. | 登録日 | 2016-03-02 | 公開日 | 2016-05-11 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (5 Å) | 主引用文献 | Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
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5FXJ
| GluN1b-GluN2B NMDA receptor structure-Class X | 分子名称: | GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1, NMDA 2B | 著者 | Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa H, H. | 登録日 | 2016-03-02 | 公開日 | 2016-05-25 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (6.25 Å) | 主引用文献 | Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
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5OJK
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5OJ2
| Crystal structure of the chicken MDGA1 ectodomain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAM domain-containing glycosylphosphatidylinositol anchor protein 1, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Elegheert, J, Clayton, A.J, Aricescu, A.R. | 登録日 | 2017-07-20 | 公開日 | 2017-08-23 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins. Neuron, 95, 2017
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5OJ6
| Crystal structure of the chicken MDGA1 ectodomain in complex with the human neuroligin 1 (NL1(-A-B)) cholinesterase domain. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAM domain-containing glycosylphosphatidylinositol anchor protein 1, Neuroligin-1, ... | 著者 | Elegheert, J, Clayton, A.J, Aricescu, A.R. | 登録日 | 2017-07-20 | 公開日 | 2017-08-23 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins. Neuron, 95, 2017
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4KFQ
| Crystal structure of the NMDA receptor GluN1 ligand binding domain in complex with 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one | 分子名称: | 1-sulfanyl[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one, GLYCEROL, Glutamate receptor ionotropic, ... | 著者 | Steffensen, T.B, Tabrizi, F.M, Gajhede, M, Kastrup, J.S. | 登録日 | 2013-04-27 | 公開日 | 2013-10-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. J.Biol.Chem., 288, 2013
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8IE2
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