2Y7Q
| THE HIGH-AFFINITY COMPLEX BETWEEN IGE AND ITS RECEPTOR FC EPSILON RI | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT ALPHA, IG EPSILON CHAIN C REGION, ... | 著者 | Davies, A.M, Holdom, M.D, Nettleship, J.E, Beavil, A.J, Owens, R.J, Sutton, B.J. | 登録日 | 2011-02-01 | 公開日 | 2011-04-20 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Conformational Changes in Ige Contribute to its Uniquely Slow Dissociation Rate from Receptor Fceri Nat.Struct.Mol.Biol., 18, 2011
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4BUH
| Human IgE against the major allergen Bet v 1 - Crystal structure of clone M0418 scFv | 分子名称: | 1,2-ETHANEDIOL, CLONE M0418 SCFV, DI(HYDROXYETHYL)ETHER | 著者 | Davies, A.M, Levin, M, Lilljekvist, M, Carlsson, F, Gould, H.J, Sutton, B.J, Ohlin, M. | 登録日 | 2013-06-20 | 公開日 | 2013-11-20 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Human Ige Against the Major Allergen Bet V 1 - Defining an Epitope with Limited Cross-Reactivity between Different Pr-10 Family Proteins Clin.Exp.Allergy, 44, 2014
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5O9M
| Crystal structure of human Histamine-Releasing Factor (HRF/TCTP)containing a disulphide-linked dimer | 分子名称: | DI(HYDROXYETHYL)ETHER, Translationally-controlled tumor protein | 著者 | Dore, K.A, Kashiwakura, J, McDonnell, J.M, Gould, H.J, Kawakami, T, Sutton, B.J, Davies, A.M. | 登録日 | 2017-06-19 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation. Mol. Immunol., 93, 2017
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5O9L
| Crystal structure of human Histamine-Releasing Factor (HRF/TCTP) | 分子名称: | Translationally-controlled tumor protein | 著者 | Dore, K.A, Kashiwakura, J, McDonnell, J.M, Gould, H.J, Kawakami, T, Sutton, B.J, Davies, A.M. | 登録日 | 2017-06-19 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation. Mol. Immunol., 93, 2017
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5O9K
| Crystal structure of Murine Histmaine-Releasing Factor (HRF/TCTP) | 分子名称: | GLYCEROL, Translationally-controlled tumor protein | 著者 | Dore, K.A, Kashiwakura, J, McDonnell, J.M, Gould, H.J, Kawakami, T, Sutton, B.J, Davies, A.M. | 登録日 | 2017-06-19 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (4.014 Å) | 主引用文献 | Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation. Mol. Immunol., 93, 2017
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5OTJ
| Monomeric polcalcin (Phl p 7) in complex with two identical allergen-specific antibodies | 分子名称: | 1,2-ETHANEDIOL, 102.1F10 Fab heavy chain, 102.1F10 Fab light chain, ... | 著者 | Mitropoulou, A.N, Davies, A.M, Beavil, A.J, McDonnell, J.M, Sutton, B.J. | 登録日 | 2017-08-22 | 公開日 | 2018-09-05 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6Y0L
| Crystal structure of human CD23 lectin domain N225D, K229E, S252N, T251N, R253G, S254G mutant | 分子名称: | GLYCEROL, Low affinity immunoglobulin epsilon Fc receptor membrane-bound form, SULFATE ION | 著者 | Ilkow, V.F, Davies, A.M, Sutton, B.J, McDonnell, J.M. | 登録日 | 2020-02-09 | 公開日 | 2021-06-16 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Reviving lost binding sites: Exploring calcium-binding site transitions between human and murine CD23. Febs Open Bio, 11, 2021
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6Y0M
| Crystal structure of human CD23 lectin domain N225D, K229E, S252N, T251N mutant | 分子名称: | Low affinity immunoglobulin epsilon Fc receptor membrane-bound form | 著者 | Ilkow, V.F, Davies, A.M, Sutton, B.J, McDonnell, J.M. | 登録日 | 2020-02-09 | 公開日 | 2021-06-16 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Reviving lost binding sites: Exploring calcium-binding site transitions between human and murine CD23. Febs Open Bio, 11, 2021
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6EYO
| Structure of extended IgE-Fc in complex with two anti-IgE Fabs | 分子名称: | 8D6 Fab heavy chain, 8D6 Fab light chain, Immunoglobulin heavy constant epsilon, ... | 著者 | Chen, J.B, Ramadani, F, Pang, M.O.Y, Beavil, R.L, Holdom, M.D, Mitropoulou, A.N, Beavil, A.J, Gould, H.J, Chang, T.W, Sutton, B.J, McDonnell, J.M, Davies, A.M. | 登録日 | 2017-11-13 | 公開日 | 2018-08-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody. Sci Rep, 8, 2018
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6EYN
| Structure of the 8D6 (anti-IgE) Fab | 分子名称: | 1,2-ETHANEDIOL, 8D6 Fab heavy chain, 8D6 Fab light chain, ... | 著者 | Chen, J.B, Ramadani, F, Pang, M.O.Y, Beavil, R.L, Holdom, M.D, Mitropoulou, A.N, Beavil, A.J, Gould, H.J, Chang, T.W, Sutton, B.J, McDonnell, J.M, Davies, A.M. | 登録日 | 2017-11-13 | 公開日 | 2018-08-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody. Sci Rep, 8, 2018
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4AOJ
| Human TrkA in complex with the inhibitor AZ-23 | 分子名称: | 5-chloranyl-N2-[(1S)-1-(5-fluoranylpyridin-2-yl)ethyl]-N4-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine, HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR, ZINC ION | 著者 | Wang, T, Lamb, M.L, Block, M.H, Davies, A.M, Han, Y, Hoffmann, E, Ioannidis, S, Josey, J.A, Liu, Z, Lyne, P.D, MacIntyre, T, Mohr, P.J, Omer, C.A, Sjogren, T, Thress, K, Wang, B, Wang, H, Yu, D, Zhang, H. | 登録日 | 2012-03-28 | 公開日 | 2012-08-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Discovery of Disubstituted Imidazo[4,5-B]Pyridines and Purines as Potent Trka Inhibitors Acs Med.Chem.Lett., 3, 2012
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5MOI
| Crystal structure of human IgE-Fc epsilon 3-4 | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Ig epsilon chain C region, ... | 著者 | Dore, K.A, Davies, A.M, Drinkwater, N, Beavil, A.J, McDonnell, J.M, Sutton, B.J. | 登録日 | 2016-12-14 | 公開日 | 2018-01-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Thermal sensitivity and flexibility of the C epsilon 3 domains in immunoglobulin E. Biochim. Biophys. Acta, 1865, 2017
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5MOJ
| Crystal structure of IgE-Fc epsilon 3-4 | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Ig epsilon chain C region, ... | 著者 | Dore, K.A, Davies, A.M, Drinkwater, N, Beavil, A.J, MacDonnell, J.M, Sutton, B.J. | 登録日 | 2016-12-14 | 公開日 | 2018-01-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Thermal sensitivity and flexibility of the C epsilon 3 domains in immunoglobulin E. Biochim. Biophys. Acta, 1865, 2017
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5MOL
| Human IgE-Fc crystal structure | 分子名称: | 1,2-ETHANEDIOL, 2-(2-ETHOXYETHOXY)ETHANOL, 2-(2-METHOXYETHOXY)ETHANOL, ... | 著者 | Dore, K.A, Davies, A.M, Drinkwater, N, Beavil, A.J, McDonnell, J.M, Sutton, B.J. | 登録日 | 2016-12-14 | 公開日 | 2018-01-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Thermal sensitivity and flexibility of the C epsilon 3 domains in immunoglobulin E. Biochim. Biophys. Acta, 1865, 2017
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5MOK
| Crystal structure of human IgE-Fc epsilon 3-4 | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Ig epsilon chain C region, ... | 著者 | Dore, K.A, Davies, A.M, Drinkwater, N, Beavil, A.J, McDonnell, J.M, Sutton, B.J. | 登録日 | 2016-12-14 | 公開日 | 2018-01-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Thermal sensitivity and flexibility of the C epsilon 3 domains in immunoglobulin E. Biochim. Biophys. Acta, 1865, 2017
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6TCN
| Crystal structure of the omalizumab Fab - crystal form II | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... | 著者 | Mitropoulou, A.N, Ceska, T, Beavil, A.J, Henry, A.J, McDonnell, J.M, Sutton, B.J, Davies, A.M. | 登録日 | 2019-11-06 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization. Acta Crystallogr.,Sect.F, 76, 2020
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6TCP
| Crystal structure of the omalizumab Fab Leu158Pro light chain mutant - crystal form II | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Omalizumab Fab Leu158Pro light chain mutant, ... | 著者 | Mitropoulou, A.N, Ceska, T, Beavil, A.J, Henry, A.J, McDonnell, J.M, Sutton, B.J, Davies, A.M. | 登録日 | 2019-11-06 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization. Acta Crystallogr.,Sect.F, 76, 2020
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6TCR
| Crystal structure of the omalizumab Fab Ser81Arg, Gln83Arg and Leu158Pro light chain mutant | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Omalizumab Fab Ser81Arg, ... | 著者 | Mitropoulou, A.N, Ceska, T, Beavil, A.J, Henry, A.J, McDonnell, J.M, Sutton, B.J, Davies, A.M. | 登録日 | 2019-11-06 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization. Acta Crystallogr.,Sect.F, 76, 2020
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6TCO
| Crystal structure of the omalizumab Fab Leu158Pro light chain mutant - crystal form I | 分子名称: | 1,2-ETHANEDIOL, Omalizumab Fab Leu158Pro light chain mutant, SULFATE ION | 著者 | Mitropoulou, A.N, Ceska, T, Beavil, A.J, Henry, A.J, McDonnell, J.M, Sutton, B.J, Davies, A.M. | 登録日 | 2019-11-06 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization. Acta Crystallogr.,Sect.F, 76, 2020
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6TCM
| Crystal structure of the omalizumab Fab - crystal form I | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, Omalizumab Fab, ... | 著者 | Mitropoulou, A.N, Ceska, T, Beavil, A.J, Henry, A.J, McDonnell, J.M, Sutton, B.J, Davies, A.M. | 登録日 | 2019-11-06 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization. Acta Crystallogr.,Sect.F, 76, 2020
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6TCS
| Crystal structure of the omalizumab scFv | 分子名称: | DI(HYDROXYETHYL)ETHER, Omalizumab scFv | 著者 | Mitropoulou, A.N, Ceska, T, Beavil, A.J, Henry, A.J, McDonnell, J.M, Sutton, B.J, Davies, A.M. | 登録日 | 2019-11-06 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization. Acta Crystallogr.,Sect.F, 76, 2020
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6TCQ
| Crystal structure of the omalizumab Fab Ser81Arg and Gln83Arg light chain mutant | 分子名称: | GLYCEROL, Omalizumab Fab Ser81Arg and Gln83Arg light chain mutant | 著者 | Mitropoulou, A.N, Ceska, T, Beavil, A.J, Henry, A.J, McDonnell, J.M, Sutton, B.J, Davies, A.M. | 登録日 | 2019-11-06 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization. Acta Crystallogr.,Sect.F, 76, 2020
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2VUO
| Crystal structure of the rabbit IgG Fc fragment | 分子名称: | AZIDE ION, FORMIC ACID, GLYCEROL, ... | 著者 | Girardi, E, Holdom, M.D, Davies, A.M, Sutton, B.J, Beavil, A.J. | 登録日 | 2008-05-27 | 公開日 | 2008-09-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The Crystal Structure of Rabbit Igg-Fc. Biochem.J., 417, 2009
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8GKF
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4UX6
| The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS) | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, NITRIC OXIDE SYNTHASE, INDUCIBLE, ... | 著者 | Cheshire, D.R, Andrews, G, Beaton, H.G, Birkinshaw, T, Boughton-Smith, N, Connolly, S, Cook, T.R, Cooper, A, Cooper, S.L, Cox, D, Dixon, J, Gensmantel, N, Hamley, P.J, Harrison, R, Hartopp, P, Kack, H, Luker, T, Mete, A, Millichip, I, Nicholls, D.J, Pimm, A.D, St-Gallay, S.A, Wallace, A.V. | 登録日 | 2014-08-19 | 公開日 | 2014-10-08 | 最終更新日 | 2018-01-17 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The Discovery of Novel, Potent and Highly Selective Inhibitors of Inducible Nitric Oxide Synthase (Inos). Bioorg.Med.Chem.Lett., 21, 2011
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