6TCQ
Crystal structure of the omalizumab Fab Ser81Arg and Gln83Arg light chain mutant
Summary for 6TCQ
Entry DOI | 10.2210/pdb6tcq/pdb |
Descriptor | Omalizumab Fab Ser81Arg and Gln83Arg light chain mutant, GLYCEROL, ... (4 entities in total) |
Functional Keywords | fab, antibody, immunoglobulin, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 48786.05 |
Authors | Mitropoulou, A.N.,Ceska, T.,Beavil, A.J.,Henry, A.J.,McDonnell, J.M.,Sutton, B.J.,Davies, A.M. (deposition date: 2019-11-06, release date: 2020-03-18, Last modification date: 2024-01-24) |
Primary citation | Mitropoulou, A.N.,Ceska, T.,Heads, J.T.,Beavil, A.J.,Henry, A.J.,McDonnell, J.M.,Sutton, B.J.,Davies, A.M. Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization. Acta Crystallogr.,Sect.F, 76:116-129, 2020 Cited by PubMed: 32133997DOI: 10.1107/S2053230X20001466 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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