8GKF

Phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis in complex with Raltitrexed.

Summary for 8GKF

Entry DOI	10.2210/pdb8gkf/pdb
Descriptor	4'-phosphopantetheinyl transferase PptT, TOMUDEX (3 entities in total)
Functional Keywords	complex, inhibitor, drug, structural genomics, tb structural genomics consortium, tbsgc, transferase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	9
Total formula weight	235070.63
Authors	Krieger, I.V.,Singh, A.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2023-03-18, release date: 2024-03-20, Last modification date: 2024-03-27)
Primary citation	Singh, A.,Ottavi, S.,Krieger, I.,Planck, K.,Perkowski, A.,Kaneko, T.,Davis, A.M.,Suh, C.,Zhang, D.,Goullieux, L.,Alex, A.,Roubert, C.,Gardner, M.,Preston, M.,Smith, D.M.,Ling, Y.,Roberts, J.,Cautain, B.,Upton, A.,Cooper, C.B.,Serbina, N.,Tanvir, Z.,Mosior, J.,Ouerfelli, O.,Yang, G.,Gold, B.S.,Rhee, K.Y.,Sacchettini, J.C.,Fotouhi, N.,Aube, J.,Nathan, C. Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase. Sci Adv, 10:eadj6406-eadj6406, 2024 Cited by PubMed: 38489355 DOI: 10.1126/sciadv.adj6406 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation