Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8GKF

Phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis in complex with Raltitrexed.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
A	0009237	biological_process	siderophore metabolic process
A	0009239	biological_process	enterobactin biosynthetic process
A	0009366	cellular_component	enterobactin synthetase complex
A	0016740	molecular_function	transferase activity
A	0016780	molecular_function	phosphotransferase activity, for other substituted phosphate groups
A	0019290	biological_process	siderophore biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
B	0009237	biological_process	siderophore metabolic process
B	0009239	biological_process	enterobactin biosynthetic process
B	0009366	cellular_component	enterobactin synthetase complex
B	0016740	molecular_function	transferase activity
B	0016780	molecular_function	phosphotransferase activity, for other substituted phosphate groups
B	0019290	biological_process	siderophore biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
C	0009237	biological_process	siderophore metabolic process
C	0009239	biological_process	enterobactin biosynthetic process
C	0009366	cellular_component	enterobactin synthetase complex
C	0016740	molecular_function	transferase activity
C	0016780	molecular_function	phosphotransferase activity, for other substituted phosphate groups
C	0019290	biological_process	siderophore biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
D	0009237	biological_process	siderophore metabolic process
D	0009239	biological_process	enterobactin biosynthetic process
D	0009366	cellular_component	enterobactin synthetase complex
D	0016740	molecular_function	transferase activity
D	0016780	molecular_function	phosphotransferase activity, for other substituted phosphate groups
D	0019290	biological_process	siderophore biosynthetic process
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
E	0009237	biological_process	siderophore metabolic process
E	0009239	biological_process	enterobactin biosynthetic process
E	0009366	cellular_component	enterobactin synthetase complex
E	0016740	molecular_function	transferase activity
E	0016780	molecular_function	phosphotransferase activity, for other substituted phosphate groups
E	0019290	biological_process	siderophore biosynthetic process
E	0046872	molecular_function	metal ion binding
F	0000287	molecular_function	magnesium ion binding
F	0005515	molecular_function	protein binding
F	0005886	cellular_component	plasma membrane
F	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
F	0009237	biological_process	siderophore metabolic process
F	0009239	biological_process	enterobactin biosynthetic process
F	0009366	cellular_component	enterobactin synthetase complex
F	0016740	molecular_function	transferase activity
F	0016780	molecular_function	phosphotransferase activity, for other substituted phosphate groups
F	0019290	biological_process	siderophore biosynthetic process
F	0046872	molecular_function	metal ion binding
G	0000287	molecular_function	magnesium ion binding
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
G	0009237	biological_process	siderophore metabolic process
G	0009239	biological_process	enterobactin biosynthetic process
G	0009366	cellular_component	enterobactin synthetase complex
G	0016740	molecular_function	transferase activity
G	0016780	molecular_function	phosphotransferase activity, for other substituted phosphate groups
G	0019290	biological_process	siderophore biosynthetic process
G	0046872	molecular_function	metal ion binding
H	0000287	molecular_function	magnesium ion binding
H	0005515	molecular_function	protein binding
H	0005886	cellular_component	plasma membrane
H	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
H	0009237	biological_process	siderophore metabolic process
H	0009239	biological_process	enterobactin biosynthetic process
H	0009366	cellular_component	enterobactin synthetase complex
H	0016740	molecular_function	transferase activity
H	0016780	molecular_function	phosphotransferase activity, for other substituted phosphate groups
H	0019290	biological_process	siderophore biosynthetic process
H	0046872	molecular_function	metal ion binding
I	0000287	molecular_function	magnesium ion binding
I	0005515	molecular_function	protein binding
I	0005886	cellular_component	plasma membrane
I	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
I	0009237	biological_process	siderophore metabolic process
I	0009239	biological_process	enterobactin biosynthetic process
I	0009366	cellular_component	enterobactin synthetase complex
I	0016740	molecular_function	transferase activity
I	0016780	molecular_function	phosphotransferase activity, for other substituted phosphate groups
I	0019290	biological_process	siderophore biosynthetic process
I	0046872	molecular_function	metal ion binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	54
Details	BINDING: BINDING => ECO:0000269\|PubMed:24963544, ECO:0000269\|PubMed:25450595, ECO:0000269\|Ref.11

Chain	Residue	Details
A	ARG48
B	THR92
B	LYS161
B	LEU171
C	ARG48
C	ARG56
C	LYS75
C	THR92
C	LYS161
C	LEU171
D	ARG48
A	ARG56
D	ARG56
D	LYS75
D	THR92
D	LYS161
D	LEU171
E	ARG48
E	ARG56
E	LYS75
E	THR92
E	LYS161
A	LYS75
E	LEU171
F	ARG48
F	ARG56
F	LYS75
F	THR92
F	LYS161
F	LEU171
G	ARG48
G	ARG56
G	LYS75
A	THR92
G	THR92
G	LYS161
G	LEU171
H	ARG48
H	ARG56
H	LYS75
H	THR92
H	LYS161
H	LEU171
I	ARG48
A	LYS161
I	ARG56
I	LYS75
I	THR92
I	LYS161
I	LEU171
A	LEU171
B	ARG48
B	ARG56
B	LYS75

site_id	SWS_FT_FI2
Number of Residues	27
Details	BINDING: BINDING => ECO:0000269\|PubMed:25450595, ECO:0007744\|PDB:4QVH

Chain	Residue	Details
A	ASP114
D	ASP114
D	ALA115
D	GLU116
E	ASP114
E	ALA115
E	GLU116
F	ASP114
F	ALA115
F	GLU116
G	ASP114
A	ALA115
G	ALA115
G	GLU116
H	ASP114
H	ALA115
H	GLU116
I	ASP114
I	ALA115
I	GLU116
A	GLU116
B	ASP114
B	ALA115
B	GLU116
C	ASP114
C	ALA115
C	GLU116

site_id	SWS_FT_FI3
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269\|PubMed:24963544, ECO:0000269\|Ref.11

Chain	Residue	Details
A	GLU157
B	GLU157
C	GLU157
D	GLU157
E	GLU157
F	GLU157
G	GLU157
H	GLU157
I	GLU157

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)