6TCP

Crystal structure of the omalizumab Fab Leu158Pro light chain mutant - crystal form II

Summary for 6TCP

Entry DOI	10.2210/pdb6tcp/pdb
Descriptor	Omalizumab Fab Leu158Pro light chain mutant, SULFATE ION, GLYCEROL, ... (6 entities in total)
Functional Keywords	fab, antibody, immunoglobulin, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	196490.78
Authors	Mitropoulou, A.N.,Ceska, T.,Beavil, A.J.,Henry, A.J.,McDonnell, J.M.,Sutton, B.J.,Davies, A.M. (deposition date: 2019-11-06, release date: 2020-03-18, Last modification date: 2024-01-24)
Primary citation	Mitropoulou, A.N.,Ceska, T.,Heads, J.T.,Beavil, A.J.,Henry, A.J.,McDonnell, J.M.,Sutton, B.J.,Davies, A.M. Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization. Acta Crystallogr.,Sect.F, 76:116-129, 2020 Cited by PubMed: 32133997 DOI: 10.1107/S2053230X20001466 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation