6TCP

Crystal structure of the omalizumab Fab Leu158Pro light chain mutant - crystal form II

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 L 301

Chain	Residue
L	GLN41
L	LYS43
L	LYS49

---

site_id	AC2
Number of Residues	1
Details	binding site for residue GOL L 302

Chain	Residue
L	ARG215

---

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL L 303

Chain	Residue
L	PRO63
L	ARG65
L	GLU85
L	GOL306

---

site_id	AC4
Number of Residues	8
Details	binding site for residue GOL L 304

Chain	Residue
H	PRO175
H	SER185
H	LEU186
H	SER187
L	GLN164
L	SER180
L	THR182
H	PHE174

---

site_id	AC5
Number of Residues	2
Details	binding site for residue PEG L 305

Chain	Residue
L	GLY161
L	SER163

---

site_id	AC6
Number of Residues	6
Details	binding site for residue GOL L 306

Chain	Residue
B	TYR33
B	TYR54
B	HIS105
L	GLN83
L	GLU85
L	GOL303

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 H 301

Chain	Residue
H	SER100
H	HIS101
H	TYR102

---

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 H 302

Chain	Residue
A	ARG112
A	THR113
H	TYR27
H	ARG98
H	HOH410

---

site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 A 301

Chain	Residue
A	LYS43
A	LYS49
A	HOH407

---

site_id	AD1
Number of Residues	1
Details	binding site for residue GOL A 302

Chain	Residue
A	ARG215

---

site_id	AD2
Number of Residues	4
Details	binding site for residue GOL A 303

Chain	Residue
A	SER14
A	LYS111
A	ARG112
H	SER28

---

site_id	AD3
Number of Residues	7
Details	binding site for residue SO4 B 301

Chain	Residue
B	ARG98
B	SER100
B	HIS101
B	TYR102
B	GOL302
B	HOH401
B	HOH437

---

site_id	AD4
Number of Residues	5
Details	binding site for residue GOL B 302

Chain	Residue
B	PHE103
B	SO4301
B	HOH403
L	ARG112
L	ASP174

---

site_id	AD5
Number of Residues	6
Details	binding site for residue SO4 C 301

Chain	Residue
B	ARG87
B	ALA88
C	LYS153
C	GLU199
C	HOH401
C	HOH419

---

site_id	AD6
Number of Residues	2
Details	binding site for residue SO4 C 302

Chain	Residue
C	LYS43
C	LYS49

---

site_id	AD7
Number of Residues	4
Details	binding site for residue SO4 D 301

Chain	Residue
D	TYR33
D	ARG98
D	HIS101
D	TYR102

---

site_id	AD8
Number of Residues	4
Details	binding site for residue GOL D 302

Chain	Residue
D	GLY32
D	TYR33
D	SER100
D	HIS101

---

site_id	AD9
Number of Residues	2
Details	binding site for residue GOL D 303

Chain	Residue
D	HIS105
D	TRP106

---

site_id	AE1
Number of Residues	3
Details	binding site for residue SO4 E 301

Chain	Residue
E	GLN41
E	LYS43
E	LYS49

---

site_id	AE2
Number of Residues	7
Details	binding site for residue GOL E 302

Chain	Residue
E	LEU58
E	GLU59
E	SER60
E	GLY61
E	VAL62
F	THR69
F	ASN84

---

site_id	AE3
Number of Residues	7
Details	binding site for residue SO4 F 301

Chain	Residue
F	TYR33
F	ARG98
F	SER100
F	HIS101
F	TYR102
F	HOH401
F	HOH404

---

site_id	AE4
Number of Residues	4
Details	binding site for residue GOL F 302

Chain	Residue
F	TYR33
F	TYR54
F	HIS101
F	HIS105

---

site_id	AE5
Number of Residues	2
Details	binding site for residue SO4 F 303

Chain	Residue
F	ARG72
F	ASP74

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR196-HIS202
H	TYR202-HIS208

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