6TCR

Crystal structure of the omalizumab Fab Ser81Arg, Gln83Arg and Leu158Pro light chain mutant

Summary for 6TCR

Entry DOI	10.2210/pdb6tcr/pdb
Descriptor	Omalizumab Fab Ser81Arg, Gln83Arg and Leu158Pro light chain mutant, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
Functional Keywords	fab, antibody, immunoglobulin, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	49280.58
Authors	Mitropoulou, A.N.,Ceska, T.,Beavil, A.J.,Henry, A.J.,McDonnell, J.M.,Sutton, B.J.,Davies, A.M. (deposition date: 2019-11-06, release date: 2020-03-18, Last modification date: 2024-01-24)
Primary citation	Mitropoulou, A.N.,Ceska, T.,Heads, J.T.,Beavil, A.J.,Henry, A.J.,McDonnell, J.M.,Sutton, B.J.,Davies, A.M. Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization. Acta Crystallogr.,Sect.F, 76:116-129, 2020 Cited by PubMed: 32133997 DOI: 10.1107/S2053230X20001466 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation