6TCR

Crystal structure of the omalizumab Fab Ser81Arg, Gln83Arg and Leu158Pro light chain mutant

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue EDO H 301

Chain	Residue
H	TYR102
H	HIS105
H	TRP106
H	HIS107
L	TYR36
L	MET37
L	ASN38
L	ALA54
L	SER95

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site_id	AC2
Number of Residues	4
Details	binding site for residue EDO H 302

Chain	Residue
H	SER128
H	VAL129
H	GLN179
H	SER180

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site_id	AC3
Number of Residues	5
Details	binding site for residue EDO H 303

Chain	Residue
H	SER31
H	GLY32
H	TYR54
H	HIS101
H	HOH453

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site_id	AC4
Number of Residues	3
Details	binding site for residue EDO L 301

Chain	Residue
L	LYS43
L	LYS49
L	EDO302

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site_id	AC5
Number of Residues	7
Details	binding site for residue EDO L 302

Chain	Residue
L	GLN41
L	LYS43
L	LYS49
L	PRO63
L	ARG65
L	EDO301
L	HOH402

---

site_id	AC6
Number of Residues	10
Details	binding site for residue PEG L 303

Chain	Residue
H	ARG19
H	GLN82
L	SER14
L	VAL15
L	ILE110
L	LYS111
L	ARG112
L	LYS173
L	ASP174
L	SER175

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO L 304

Chain	Residue
H	TYR95
L	GLN42
L	LYS43
L	PRO44
L	GLY45
L	LYS46
L	HOH507

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO L 305

Chain	Residue
H	ASN212
L	VAL154
L	GLN159
L	HIS193

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site_id	AC9
Number of Residues	3
Details	binding site for residue EDO L 306

Chain	Residue
L	SER163
L	GLN164
L	GLU165

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR196-HIS202
H	TYR202-HIS208

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