4BUH

Human IgE against the major allergen Bet v 1 - Crystal structure of clone M0418 scFv

Summary for 4BUH

Entry DOI	10.2210/pdb4buh/pdb
Descriptor	CLONE M0418 SCFV, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
Functional Keywords	immune system, antibody, allergen
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	57785.20
Authors	Davies, A.M.,Levin, M.,Lilljekvist, M.,Carlsson, F.,Gould, H.J.,Sutton, B.J.,Ohlin, M. (deposition date: 2013-06-20, release date: 2013-11-20, Last modification date: 2024-11-20)
Primary citation	Levin, M.,Davies, A.M.,Lilljekvist, M.,Carlsson, F.,Gould, H.J.,Sutton, B.J.,Ohlin, M. Human Ige Against the Major Allergen Bet V 1 - Defining an Epitope with Limited Cross-Reactivity between Different Pr-10 Family Proteins Clin.Exp.Allergy, 44:288-, 2014 Cited by PubMed Abstract: The interaction between IgE and allergen is a key event at the initiation of an allergic response, and its characteristics have substantial effects on the clinical manifestation. Despite this, the molecular details of the interaction between human IgE and the major birch allergen Bet v 1, one of the most potent tree allergens, still remain poorly investigated. PubMed: 24447087 DOI: 10.1111/CEA.12230 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation