1Z56
| Co-Crystal Structure of Lif1p-Lig4p | 分子名称: | DNA ligase IV, Ligase interacting factor 1 | 著者 | Dore, A.S, Furnham, N, Davies, O.R, Sibanda, B.L, Chirgadze, D.Y, Jackson, S.P, Pellegrini, L, Blundell, T.L. | 登録日 | 2005-03-17 | 公開日 | 2006-01-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.92 Å) | 主引用文献 | Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode. DNA REPAIR, 5, 2006
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2ASU
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6XTY
| CryoEM structure of human CMG bound to AND-1 (CMGA) | 分子名称: | Cell division control protein 45 homolog, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | 著者 | Rzechorzek, N.J, Pellegrini, L, Chirgadze, D.Y, Hardwick, S.W. | 登録日 | 2020-01-16 | 公開日 | 2020-05-27 | 最終更新日 | 2020-07-15 | 実験手法 | ELECTRON MICROSCOPY (6.77 Å) | 主引用文献 | CryoEM structures of human CMG-ATP gamma S-DNA and CMG-AND-1 complexes. Nucleic Acids Res., 48, 2020
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5M2H
| Crystal structure of vancomycin-Zn(II)-citrate complex | 分子名称: | CITRIC ACID, HEXAETHYLENE GLYCOL, Vancomycin, ... | 著者 | Zarkan, A, Macklyne, H.-R, Chirgadze, D.Y, Bond, A.D, Hesketh, A.R, Hong, H.-J. | 登録日 | 2016-10-13 | 公開日 | 2017-07-19 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | 主引用文献 | Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria. Sci Rep, 7, 2017
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5LSP
| 107_A07 Fab in complex with fragment of the Met receptor | 分子名称: | 107_A07 Fab heavy chain, 107_A07 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | DiCara, D, Chirgadze, D.Y, Pope, A, Karatt-Vellatt, A, Winter, A, van den Heuvel, J, Gherardi, E, McCafferty, J. | 登録日 | 2016-09-05 | 公開日 | 2017-09-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.605 Å) | 主引用文献 | Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain. Sci Rep, 7, 2017
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5LUQ
| Crystal Structure of Human DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) | 分子名称: | C-terminal fragment of KU80 (KU80ct194), DNA-dependent protein kinase catalytic subunit,DNA-dependent Protein Kinase Catalytic Subunit,DNA-dependent protein kinase catalytic subunit | 著者 | Sibanda, B.L, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L. | 登録日 | 2016-09-09 | 公開日 | 2017-02-15 | 最終更新日 | 2018-03-28 | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | 主引用文献 | DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair. Science, 355, 2017
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5M2K
| Crystal structure of vancomycin-Zn(II) complex | 分子名称: | 1,2-ETHANEDIOL, ZINC ION, vancomycin, ... | 著者 | Zarkan, A, Macklyne, H.-R, Chirgadze, D.Y, Bond, A.D, Hesketh, A.R, Hong, H.-J. | 登録日 | 2016-10-13 | 公開日 | 2017-07-19 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria. Sci Rep, 7, 2017
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2J66
| Structural characterisation of BtrK decarboxylase from butirosin biosynthesis | 分子名称: | 1,2-ETHANEDIOL, BTRK, PYRIDOXAL-5'-PHOSPHATE | 著者 | Popovic, B, Li, Y, Chirgadze, D.Y, Blundell, T.L, Spencer, J.B. | 登録日 | 2006-09-26 | 公開日 | 2006-09-28 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural Characterisation of Btrk Decarboxylase from Bacillus Circulans Butirosin Biosynthesis To be Published
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2OFP
| Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate | 分子名称: | 1,4-DIETHYLENE DIOXIDE, ACETATE ION, Ketopantoate reductase, ... | 著者 | Ciulli, A, Chirgadze, D.Y, Smith, A.G, Blundell, T.L, Abell, C. | 登録日 | 2007-01-04 | 公開日 | 2007-01-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure of Escherichia coli Ketopantoate Reductase in a Ternary Complex with NADP+ and Pantoate Bound: SUBSTRATE RECOGNITION, CONFORMATIONAL CHANGE, AND COOPERATIVITY. J.Biol.Chem., 282, 2007
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3SI5
| Kinetochore-BUBR1 kinase complex | 分子名称: | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, Protein CASC5 | 著者 | Blundell, T.L, Chirgadze, D.Y, Bolanos-Garcia, V.M. | 登録日 | 2011-06-17 | 公開日 | 2011-10-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site. Structure, 19, 2011
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4H7Y
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4I0C
| The structure of the camelid antibody cAbHuL5 in complex with human lysozyme | 分子名称: | CHLORIDE ION, GLYCEROL, Lysozyme C, ... | 著者 | De Genst, E, Chan, P.H, Pardon, E, Kumita, J.R, Christodoulou, J, Menzer, L, Chirgadze, D.Y, Robinson, C.V, Muyldermans, S, Matagne, A, Wyns, L, Dobson, C.M, Dumoulin, M. | 登録日 | 2012-11-16 | 公開日 | 2013-10-09 | 最終更新日 | 2013-11-06 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation. J.Phys.Chem.B, 117, 2013
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4L1D
| Voltage-gated sodium channel beta3 subunit Ig domain | 分子名称: | Sodium channel subunit beta-3 | 著者 | Namadurai, S, Weimhofer, M, Rajappa, R, Stott, K, Klingauf, J, Chirgadze, D.Y, Jackson, A.P. | 登録日 | 2013-06-03 | 公開日 | 2014-03-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure and Molecular Imaging of the Nav Channel beta 3 Subunit Indicates a Trimeric Assembly. J.Biol.Chem., 289, 2014
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1GMN
| CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEPATOCYTE GROWTH FACTOR | 著者 | Lietha, D, Chirgadze, D.Y, Mulloy, B, Blundell, T.L, Gherardi, E. | 登録日 | 2001-09-19 | 公開日 | 2001-10-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor Embo J., 20, 2001
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1GMO
| CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, ... | 著者 | Lietha, D, Chirgadze, D.Y, Mulloy, B, Blundell, T.L, Gherardi, E. | 登録日 | 2001-09-20 | 公開日 | 2001-10-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor Embo J., 20, 2001
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1GP9
| A New Crystal Form of the Nk1 Splice Variant of Hgf/Sf Demonstrates Extensive Hinge Movement and Suggests that the Nk1 Dimer Originates by Domain Swapping | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEPATOCYTE GROWTH FACTOR | 著者 | Watanabe, K, Chirgadze, D.Y, Lietha, D, Gherardi, E, Blundell, T.L. | 登録日 | 2001-10-31 | 公開日 | 2001-11-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A New Crystal Form of the Nk1 Splice Variant of Hgf/Sf Demonstrates Extensive Hinge Movement and Suggests that the Nk1 Dimer Originates by Domain Swapping J.Mol.Biol., 319, 2002
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6ZH8
| Cryo-EM structure of DNA-PKcs:DNA | 分子名称: | DNA (5'-D(P*AP*CP*TP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*T)-3'), DNA-dependent protein kinase catalytic subunit,DNA-PKcs | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2020-06-21 | 公開日 | 2020-10-21 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
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3COV
| Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.5 Ang resolution- apo form | 分子名称: | ETHANOL, GLYCEROL, Pantothenate synthetase, ... | 著者 | Ciulli, A, Chirgadze, D.Y, Blundell, T.L, Abell, C. | 登録日 | 2008-03-29 | 公開日 | 2008-10-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate. Chembiochem, 9, 2008
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3COY
| Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.05 Ang resolution- in complex with sulphonamide inhibitor 3 | 分子名称: | 5'-O-[(3-methyl-D-valyl)sulfamoyl]adenosine, ETHANOL, GLYCEROL, ... | 著者 | Ciulli, A, Chirgadze, D.Y, Blundell, T.L, Abell, C. | 登録日 | 2008-03-29 | 公開日 | 2008-10-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate. Chembiochem, 9, 2008
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3COZ
| Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.0 Ang resolution- in complex with sulphonamide inhibitor 4 | 分子名称: | 5'-O-(D-valylsulfamoyl)adenosine, ETHANOL, GLYCEROL, ... | 著者 | Ciulli, A, Chirgadze, D.Y, Blundell, T.L, Abell, C. | 登録日 | 2008-03-29 | 公開日 | 2008-10-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate. Chembiochem, 9, 2008
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3COW
| Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.8 Ang resolution- in complex with sulphonamide inhibitor 2 | 分子名称: | 5'-O-{[(2R)-2-hydroxy-3,3-dimethylbutanoyl]sulfamoyl}adenosine, ETHANOL, GLYCEROL, ... | 著者 | Ciulli, A, Chirgadze, D.Y, Blundell, T.L, Abell, C. | 登録日 | 2008-03-29 | 公開日 | 2008-10-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate. Chembiochem, 9, 2008
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2C81
| Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis. | 分子名称: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, GLUTAMINE-2-DEOXY-SCYLLO-INOSOSE AMINOTRANSFERASE | 著者 | Popovic, B, Tang, X, Chirgadze, D.Y, Huang, F, Blundell, T.L, Spencer, J.B. | 登録日 | 2005-11-30 | 公開日 | 2006-08-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis. Proteins, 65, 2006
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2C7T
| CRYSTAL STRUCTURE OF THE PLP-BOUND FORM OF BTRR, A DUAL FUNCTIONAL AMINOTRANSFERASE INVOLVED IN BUTIROSIN BIOSYNTHESIS. | 分子名称: | GLUTAMINE-2-DEOXY-SCYLLO-INOSOSE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | 著者 | Popovic, B, Tang, X, Chirgadze, D.Y, Huang, F, Blundell, T.L, Spencer, J.B. | 登録日 | 2005-11-29 | 公開日 | 2006-08-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis. Proteins, 65, 2006
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3E4R
| Crystal structure of the alkanesulfonate binding protein (SsuA) from the phytopathogenic bacteria Xanthomonas axonopodis pv. citri bound to HEPES | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Nitrate transport protein | 著者 | Balan, A, Araujo, F.T, Sanches, M, Chirgadze, D.Y, Blundell, T.B, Barbosa, J.A.R.G. | 登録日 | 2008-08-12 | 公開日 | 2008-09-23 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Crystal structure of the alkanesulfonate binding protein (SsuA) from the phytopathogenic bacteria Xanthomonas axonopodis pv. citri bound to HEPES To be Published
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3ESL
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