4I0C

The structure of the camelid antibody cAbHuL5 in complex with human lysozyme

Summary for 4I0C

DescriptorLysozyme C, cAbHuL5 antibody, CHLORIDE ION, ... (5 entities in total)
Functional Keywordsbeta-barrel, alpha-beta protein, immune recognition, glycosidase, immune system-hydrolase complex, immune system/hydrolase
Biological sourceHomo sapiens (human)
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Cellular locationSecreted P61626
Total number of polymer chains4
Total molecular weight59077.95
Authors
Primary citation
De Genst, E.,Chan, P.H.,Pardon, E.,Hsu, S.T.,Kumita, J.R.,Christodoulou, J.,Menzer, L.,Chirgadze, D.Y.,Robinson, C.V.,Muyldermans, S.,Matagne, A.,Wyns, L.,Dobson, C.M.,Dumoulin, M.
A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.
J.Phys.Chem.B, 117:13245-13258, 2013
PubMed: 23919586 (PDB entries with the same primary citation)
DOI: 10.1021/jp403425z
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.95 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21330.4%0.3%5.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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Molmil generated image of 4i0c
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4i0c.pdb2.gz [88.42 KB])
Coordinate files for Biological unit (4i0c.pdb1.gz [89.43 KB])