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3COW

Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.8 Ang resolution- in complex with sulphonamide inhibitor 2

Summary for 3COW
Entry DOI10.2210/pdb3cow/pdb
Related1MOP 1N2H 3COV 3COY 3COZ
DescriptorPantothenate synthetase, 5'-O-{[(2R)-2-hydroxy-3,3-dimethylbutanoyl]sulfamoyl}adenosine, GLYCEROL, ... (5 entities in total)
Functional Keywordsmycobacterium tuberculosis, pantothenate biosynthesis, enzymes, ligase, inhibitors, drug design, atp-binding, magnesium, metal-binding, nucleotide-binding
Biological sourceMycobacterium tuberculosis
Cellular locationCytoplasm (Potential): P0A5R0
Total number of polymer chains2
Total formula weight64339.60
Authors
Ciulli, A.,Chirgadze, D.Y.,Blundell, T.L.,Abell, C. (deposition date: 2008-03-29, release date: 2008-10-07, Last modification date: 2023-08-30)
Primary citationCiulli, A.,Scott, D.E.,Ando, M.,Reyes, F.,Saldanha, S.A.,Tuck, K.L.,Chirgadze, D.Y.,Blundell, T.L.,Abell, C.
Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.
Chembiochem, 9:2606-2611, 2008
Cited by
PubMed: 18821554
DOI: 10.1002/cbic.200800437
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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