5M2H

Crystal structure of vancomycin-Zn(II)-citrate complex

Summary for 5M2H

• Entry DOI: 10.2210/pdb5m2h/pdb
• Related PRD ID: PRD_000204
• Descriptor: Vancomycin, vancosamine-(1-2)-beta-D-glucopyranose, ZINC ION, ... (6 entities in total)
• Functional Keywords: vancomycin, zinc, glycopeptide, antibiotic
• Biological source: Amycolatopsis orientalis
• Total number of polymer chains: 2
• Total formula weight: 3678.62

Authors

Zarkan, A.,Macklyne, H.-R.,Chirgadze, D.Y.,Bond, A.D.,Hesketh, A.R.,Hong, H.-J. (deposition date: 2016-10-13, release date: 2017-07-19, Last modification date: 2020-07-29)

• Primary citation: Zarkan, A.,Macklyne, H.R.,Chirgadze, D.Y.,Bond, A.D.,Hesketh, A.R.,Hong, H.J.; Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria.; Sci Rep, 7:4893-4893, 2017; PubMed: 28687742; DOI: 10.1038/s41598-017-04868-2

Experimental method

X-RAY DIFFRACTION (0.95 Å)