5LUQ
Crystal Structure of Human DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs)
Summary for 5LUQ
Entry DOI | 10.2210/pdb5luq/pdb |
Descriptor | DNA-dependent protein kinase catalytic subunit,DNA-dependent Protein Kinase Catalytic Subunit,DNA-dependent protein kinase catalytic subunit, C-terminal fragment of KU80 (KU80ct194) (2 entities in total) |
Functional Keywords | dna-pkcs, kinase, dna repair, nhej, double strand break repair, heat repeat, transferase |
Biological source | Homo sapiens More |
Cellular location | Nucleus : P78527 |
Total number of polymer chains | 4 |
Total formula weight | 972480.57 |
Authors | Sibanda, B.L.,Chirgadze, D.Y.,Ascher, D.B.,Blundell, T.L. (deposition date: 2016-09-09, release date: 2017-02-15, Last modification date: 2018-03-28) |
Primary citation | Sibanda, B.L.,Chirgadze, D.Y.,Ascher, D.B.,Blundell, T.L. DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair. Science, 355:520-524, 2017 Cited by PubMed: 28154079DOI: 10.1126/science.aak9654 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.3 Å) |
Structure validation
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