5LSP
107_A07 Fab in complex with fragment of the Met receptor
Summary for 5LSP
Entry DOI | 10.2210/pdb5lsp/pdb |
Descriptor | Hepatocyte growth factor receptor, 107_A07 Fab heavy chain, 107_A07 Fab light chain, ... (6 entities in total) |
Functional Keywords | fab, beta propeller, ig-like domain, cell signalling, met receptor, antibody binding, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 149676.07 |
Authors | DiCara, D.,Chirgadze, D.Y.,Pope, A.,Karatt-Vellatt, A.,Winter, A.,van den Heuvel, J.,Gherardi, E.,McCafferty, J. (deposition date: 2016-09-05, release date: 2017-09-13, Last modification date: 2020-07-29) |
Primary citation | DiCara, D.M.,Chirgadze, D.Y.,Pope, A.R.,Karatt-Vellatt, A.,Winter, A.,Slavny, P.,van den Heuvel, J.,Parthiban, K.,Holland, J.,Packman, L.C.,Mavria, G.,Hoffmann, J.,Birchmeier, W.,Gherardi, E.,McCafferty, J. Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain. Sci Rep, 7:9000-9000, 2017 Cited by PubMed: 28827556DOI: 10.1038/s41598-017-09460-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.605 Å) |
Structure validation
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