5LSP

107_A07 Fab in complex with fragment of the Met receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, P)	Hepatocyte growth factor receptor	polymer	231	25592.2	2	UniProt (P08581) Pfam (PF01437) Pfam (PF01833)	Homo sapiens (Human)	HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met
2	B, E (H, S)	107_A07 Fab heavy chain	polymer	223	23891.8	2		Homo sapiens (Human)
3	C, F (L, T)	107_A07 Fab light chain	polymer	216	23504.9	2		Homo sapiens (Human)
4	G, H (X, Y)	Hepatocyte growth factor receptor	polymer	14	1627.9	2	UniProt (P08581)	Homo sapiens (Human)	HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met
5	I, J (A, P)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
6	K, L, M, N, O... (A, H, L, P, S...)	water	water		18.0	88	Chemie (HOH)

Sequence modifications

A, P: 519 - 743 (UniProt: P08581)

PDB	External Database	Details
His 744	-	expression tag
His 745	-	expression tag
His 746	-	expression tag
His 747	-	expression tag
His 748	-	expression tag
His 749	-	expression tag

X, Y: 25 - 35 (UniProt: P08581)

PDB	External Database	Details
Glu 22	-	expression tag
Thr 23	-	expression tag
Arg 24	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	149233.6
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	149676.1

*Water molecules are not included.