3COZ

Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.0 Ang resolution- in complex with sulphonamide inhibitor 4

Summary for 3COZ

Entry DOI	10.2210/pdb3coz/pdb
Related	1MOP 1N2H 3COV 3COW 3COY
Descriptor	Pantothenate synthetase, SULFATE ION, 5'-O-(D-valylsulfamoyl)adenosine, ... (6 entities in total)
Functional Keywords	mycobacterium tuberculosis, pantothenate biosynthesis, enzymes, ligase, inhibitors, drug design, atp-binding, magnesium, metal-binding, nucleotide-binding
Biological source	Mycobacterium tuberculosis
Cellular location	Cytoplasm (Potential): P0A5R0
Total number of polymer chains	2
Total formula weight	64501.75
Authors	Ciulli, A.,Chirgadze, D.Y.,Blundell, T.L.,Abell, C. (deposition date: 2008-03-29, release date: 2008-10-07, Last modification date: 2023-08-30)
Primary citation	Ciulli, A.,Scott, D.E.,Ando, M.,Reyes, F.,Saldanha, S.A.,Tuck, K.L.,Chirgadze, D.Y.,Blundell, T.L.,Abell, C. Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate. Chembiochem, 9:2606-2611, 2008 Cited by PubMed: 18821554 DOI: 10.1002/cbic.200800437 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation