6TCI
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1U36
| Crystal structure of WLAC mutant of dimerisation domain of NF-kB p50 transcription factor | 分子名称: | Nuclear factor NF-kappa-B p105 subunit | 著者 | Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M. | 登録日 | 2004-07-21 | 公開日 | 2004-08-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding Structure, 12, 2004
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1U41
| Crystal structure of YLGV mutant of dimerisation domain of NF-kB p50 transcription factor | 分子名称: | Nuclear factor NF-kappa-B p105 subunit | 著者 | Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M. | 登録日 | 2004-07-23 | 公開日 | 2004-08-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.202 Å) | 主引用文献 | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding Structure, 12, 2004
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1U3Y
| Crystal structure of ILAC mutant of dimerisation domain of NF-kB p50 transcription factor | 分子名称: | Nuclear factor NF-kappa-B p105 subunit | 著者 | Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M. | 登録日 | 2004-07-22 | 公開日 | 2004-08-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | 主引用文献 | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding Structure, 12, 2004
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1U42
| Crystal structure of MLAM mutant of dimerisation domain of NF-kB p50 transcription factor | 分子名称: | Nuclear factor NF-kappa-B p105 subunit | 著者 | Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M. | 登録日 | 2004-07-23 | 公開日 | 2004-08-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.699 Å) | 主引用文献 | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding Structure, 12, 2004
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1U3Z
| Crystal structure of MLAC mutant of dimerisation domain of NF-kB p50 transcription factor | 分子名称: | Nuclear factor NF-kappa-B p105 subunit | 著者 | Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M. | 登録日 | 2004-07-23 | 公開日 | 2004-08-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding Structure, 12, 2004
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1U3J
| Crystal structure of MLAV mutant of dimerisation domain of NF-kB p50 transcription factor | 分子名称: | Nuclear factor NF-kappa-B p105 subunit | 著者 | Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M. | 登録日 | 2004-07-22 | 公開日 | 2004-08-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | 主引用文献 | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding Structure, 12, 2004
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1NK1
| NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR (HGF/SF) AT 2.5 ANGSTROM RESOLUTION | 分子名称: | PROTEIN (HEPATOCYTE GROWTH FACTOR PRECURSOR) | 著者 | Chirgadze, D.Y, Hepple, J.P, Zhou, H, Byrd, R.A, Blundell, T.L, Gherardi, E. | 登録日 | 1998-08-20 | 公開日 | 1999-01-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding. Nat.Struct.Biol., 6, 1999
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5JIP
| Crystal structure of the Clostridium perfringens spore cortex lytic enzyme SleM | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cortical-lytic enzyme, MAGNESIUM ION | 著者 | Chirgadze, D.Y, Christie, G, Ustok, F.I, Al-Riyami, B, Stott, K. | 登録日 | 2016-04-22 | 公開日 | 2016-08-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The crystal structure of Clostridium perfringens SleM, a muramidase involved in cortical hydrolysis during spore germination. Proteins, 84, 2016
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3KX8
| Structural basis of the activity and substrate specificity of the fluoroacetyl-CoA thioesterase FlK | 分子名称: | fluoroacetyl-CoA thioesterase | 著者 | Chirgadze, D.Y, Dias, M.V.B, Huang, F, Tosin, M, Spiteller, D, Valentine, E.F, Leadlay, P.F, Spencer, J.B, Blundell, T.L. | 登録日 | 2009-12-02 | 公開日 | 2010-04-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK. J.Biol.Chem., 285, 2010
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7NFC
| Cryo-EM structure of NHEJ super-complex (dimer) | 分子名称: | DNA (27-MER), DNA (28-MER), DNA ligase 4, ... | 著者 | Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2021-02-05 | 公開日 | 2021-08-18 | 最終更新日 | 2021-09-22 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Mol.Cell, 81, 2021
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7NFE
| Cryo-EM structure of NHEJ super-complex (monomer) | 分子名称: | DNA (5'-D(P*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*CP*TP*AP*TP*TP*AP*TP*TP*AP*TP*G)-3'), DNA (5'-D(P*TP*AP*AP*TP*AP*AP*TP*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*AP*G)-3'), DNA ligase 4, ... | 著者 | Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2021-02-06 | 公開日 | 2021-08-18 | 最終更新日 | 2021-09-22 | 実験手法 | ELECTRON MICROSCOPY (4.29 Å) | 主引用文献 | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Mol.Cell, 81, 2021
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1GP9
| A New Crystal Form of the Nk1 Splice Variant of Hgf/Sf Demonstrates Extensive Hinge Movement and Suggests that the Nk1 Dimer Originates by Domain Swapping | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEPATOCYTE GROWTH FACTOR | 著者 | Watanabe, K, Chirgadze, D.Y, Lietha, D, Gherardi, E, Blundell, T.L. | 登録日 | 2001-10-31 | 公開日 | 2001-11-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A New Crystal Form of the Nk1 Splice Variant of Hgf/Sf Demonstrates Extensive Hinge Movement and Suggests that the Nk1 Dimer Originates by Domain Swapping J.Mol.Biol., 319, 2002
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3MKP
| Crystal structure of 1K1 mutant of Hepatocyte Growth Factor/Scatter Factor fragment NK1 in complex with heparin | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Gherardi, E, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2010-04-15 | 公開日 | 2010-08-18 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Engineering a fragment of Hepatocyte Growth Factor/Scatter Factor for tissue and organ regeneration To be Published
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3G04
| Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HUMAN THYROID STIMULATING AUTOANTIBODY M22 HEAVY CHAIN, HUMAN THYROID STIMULATING AUTOANTIBODY M22 LIGHT CHAIN, ... | 著者 | Sanders, J, Chirgadze, D.Y, Sanders, P, Baker, S, Sullivan, A, Bhardwaja, A, Bolton, J, Reeve, M, Nakatake, N, Evans, M, Richards, T, Powell, M, Miguel, R.N, Blundell, T.L, Furmaniak, J, Smith, B.R. | 登録日 | 2009-01-27 | 公開日 | 2009-08-04 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody Thyroid, 17, 2007
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3SI5
| Kinetochore-BUBR1 kinase complex | 分子名称: | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, Protein CASC5 | 著者 | Blundell, T.L, Chirgadze, D.Y, Bolanos-Garcia, V.M. | 登録日 | 2011-06-17 | 公開日 | 2011-10-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site. Structure, 19, 2011
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3V42
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3VNN
| Crystal Structure of a sub-domain of the nucleotidyltransferase (adenylation) domain of human DNA ligase IV | 分子名称: | DNA ligase 4 | 著者 | Ochi, T, Wu, Q, Chirgadze, D.Y, Grossmann, J.G, Bolanos-Garcia, V.M, Blundell, T.L. | 登録日 | 2012-01-17 | 公開日 | 2012-06-20 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.903 Å) | 主引用文献 | Structural insights into the role of domain flexibility in human DNA ligase IV Structure, 20, 2012
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3W03
| XLF-XRCC4 complex | 分子名称: | DNA repair protein XRCC4, Non-homologous end-joining factor 1 | 著者 | Wu, Q, Ochi, T, Matak-Vinkovic, D, Robinson, C.V, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2012-10-17 | 公開日 | 2012-11-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (8.492 Å) | 主引用文献 | Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions Biochem.Soc.Trans., 39, 2011
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8B0J
| CryoEM structure of bacterial RNaseE.RapZ.GlmZ complex central to the control of cell envelope biogenesis | 分子名称: | GlmZ small RNA, RNase adapter protein RapZ, Ribonuclease E | 著者 | Islam, M.S, Hardwick, H.W, Chirgadze, D.Y, Luisi, B.F. | 登録日 | 2022-09-07 | 公開日 | 2022-10-05 | 最終更新日 | 2023-01-25 | 実験手法 | ELECTRON MICROSCOPY (3.99 Å) | 主引用文献 | Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis. Embo J., 42, 2023
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8B0I
| CryoEM structure of bacterial RapZ.GlmZ complex central to the control of cell envelope biogenesis | 分子名称: | GlmZ small regulatory RNA, RNase adapter protein RapZ | 著者 | Islam, M.S, Hardwick, H.W, Chirgadze, D.Y, Luisi, B.F. | 登録日 | 2022-09-07 | 公開日 | 2022-10-05 | 最終更新日 | 2023-01-25 | 実験手法 | ELECTRON MICROSCOPY (4.28 Å) | 主引用文献 | Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis. Embo J., 42, 2023
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5LSP
| 107_A07 Fab in complex with fragment of the Met receptor | 分子名称: | 107_A07 Fab heavy chain, 107_A07 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | DiCara, D, Chirgadze, D.Y, Pope, A, Karatt-Vellatt, A, Winter, A, van den Heuvel, J, Gherardi, E, McCafferty, J. | 登録日 | 2016-09-05 | 公開日 | 2017-09-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.605 Å) | 主引用文献 | Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain. Sci Rep, 7, 2017
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5M2H
| Crystal structure of vancomycin-Zn(II)-citrate complex | 分子名称: | CITRIC ACID, HEXAETHYLENE GLYCOL, Vancomycin, ... | 著者 | Zarkan, A, Macklyne, H.-R, Chirgadze, D.Y, Bond, A.D, Hesketh, A.R, Hong, H.-J. | 登録日 | 2016-10-13 | 公開日 | 2017-07-19 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | 主引用文献 | Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria. Sci Rep, 7, 2017
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5LUQ
| Crystal Structure of Human DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) | 分子名称: | C-terminal fragment of KU80 (KU80ct194), DNA-dependent protein kinase catalytic subunit,DNA-dependent Protein Kinase Catalytic Subunit,DNA-dependent protein kinase catalytic subunit | 著者 | Sibanda, B.L, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L. | 登録日 | 2016-09-09 | 公開日 | 2017-02-15 | 最終更新日 | 2018-03-28 | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | 主引用文献 | DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair. Science, 355, 2017
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5M2K
| Crystal structure of vancomycin-Zn(II) complex | 分子名称: | 1,2-ETHANEDIOL, ZINC ION, vancomycin, ... | 著者 | Zarkan, A, Macklyne, H.-R, Chirgadze, D.Y, Bond, A.D, Hesketh, A.R, Hong, H.-J. | 登録日 | 2016-10-13 | 公開日 | 2017-07-19 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria. Sci Rep, 7, 2017
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