3G04

Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody

Summary for 3G04

• Entry DOI: 10.2210/pdb3g04/pdb
• Related: 1XWD
• Descriptor: HUMAN THYROID STIMULATING AUTOANTIBODY M22 LIGHT CHAIN, HUMAN THYROID STIMULATING AUTOANTIBODY M22 HEAVY CHAIN, Thyrotropin receptor, ... (6 entities in total)
• Functional Keywords: tsh receptor, gpcr, thyroid, graves' disease, autoimmunity, receptor-autoantibody complex, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 76128.97

Authors

Sanders, J.,Chirgadze, D.Y.,Sanders, P.,Baker, S.,Sullivan, A.,Bhardwaja, A.,Bolton, J.,Reeve, M.,Nakatake, N.,Evans, M.,Richards, T.,Powell, M.,Miguel, R.N.,Blundell, T.L.,Furmaniak, J.,Smith, B.R. (deposition date: 2009-01-27, release date: 2009-08-04, Last modification date: 2024-10-30)

Primary citation

Sanders, J.,Chirgadze, D.Y.,Sanders, P.,Baker, S.,Sullivan, A.,Bhardwaja, A.,Bolton, J.,Reeve, M.,Nakatake, N.,Evans, M.,Richards, T.,Powell, M.,Miguel, R.N.,Blundell, T.L.,Furmaniak, J.,Smith, B.R.
Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody
Thyroid, 17:395-410, 2007

PubMed Abstract: To analyze interactions between the thyroid-stimulating hormone receptor (TSHR) and a thyroid-stimulating human monoclonal autoantibody (M22) at the molecular level.

PubMed: 17542669
DOI: 10.1089/thy.2007.0034

Experimental method

X-RAY DIFFRACTION (2.55 Å)