1NKT
| CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS COMPLEX WITH ADPBS | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Preprotein translocase secA 1 subunit | 著者 | Sharma, V, Arockiasamy, A, Ronning, D.R, Savva, C.G, Holzenburg, A, Braunstein, M, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2003-01-03 | 公開日 | 2003-03-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | 主引用文献 | Crystal Structure of M. tuberculosis SecA, A Preprotein Translocating ATPase Proc.Natl.Acad.Sci.USA, 100, 2003
|
|
1NH7
| ATP PHOSPHORIBOSYLTRANSFERASE (ATP-PRTASE) FROM MYCOBACTERIUM TUBERCULOSIS | 分子名称: | ATP Phosphoribosyltransferase, MAGNESIUM ION, SULFATE ION | 著者 | Cho, Y, Sharma, V, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2002-12-18 | 公開日 | 2003-02-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal Structure of ATP Phosphoribosyltransferase from Mycobacterium Tuberculosis J.Biol.Chem., 278, 2003
|
|
1N8I
| Biochemical and Structural Studies of Malate Synthase from Mycobacterium tuberculosis | 分子名称: | GLYOXYLIC ACID, MAGNESIUM ION, Probable malate synthase G | 著者 | Smith, C.V, Huang, C.C, Miczak, A, Russell, D.G, Sacchettini, J.C, Honer zu Bentrup, K, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2002-11-20 | 公開日 | 2002-12-18 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis J.Biol.Chem., 278, 2003
|
|
1N8W
| Biochemical and Structural Studies of Malate Synthase from Mycobacterium tuberculosis | 分子名称: | COENZYME A, D-MALATE, GLYOXYLIC ACID, ... | 著者 | Smith, C.V, Huang, C.C, Miczak, A, Russell, D.G, Sacchettini, J.C, Honer zu Bentrup, K, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2002-11-21 | 公開日 | 2002-12-18 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis J.Biol.Chem., 278, 2003
|
|
1NHG
| CRYSTAL STRUCTURE ANALYSIS OF PLASMODIUM FALCIPARUM ENOYL-ACYL-CARRIER-PROTEIN REDUCTASE WITH TRICLOSAN | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN, enoyl-acyl carrier reductase | 著者 | Perozzo, R, Kuo, M, Sidhu, A.S, Valiyaveettil, J.T, Bittman, R, Jacobs Jr, W.R, Fidock, D.A, Sacchettini, J.C. | 登録日 | 2002-12-19 | 公開日 | 2003-02-25 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for
Malarial Enoyl Acyl Carrier Protein Reductase J.Biol.Chem., 277, 2002
|
|
1NH8
| ATP PHOSPHORIBOSYLTRANSFERASE (ATP-PRTASE) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH AMP AND HISTIDINE | 分子名称: | ADENOSINE MONOPHOSPHATE, ATP Phosphoribosyltransferase, HISTIDINE, ... | 著者 | Cho, Y, Sharma, V, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2002-12-18 | 公開日 | 2003-02-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis J.Biol.Chem., 278, 2003
|
|
1NHW
| Crystal Structure Analysis of Plasmodium falciparum enoyl-acyl-carrier-protein reductase | 分子名称: | 2-(2,4-DICHLORO-PHENYLAMINO)-PHENOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, enoyl-acyl carrier reductase | 著者 | Perozzo, R, Kuo, M, Sidhu, A.S, Valiyaveettil, J.T, Bittman, R, Jacobs Jr, W.R, Fidock, D.A, Sacchettini, J.C. | 登録日 | 2002-12-19 | 公開日 | 2003-02-25 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for
Malarial Enoyl Acyl Carrier Protein Reductase Year J.Biol.Chem., 277, 2002
|
|
1NNU
| Crystal Structure Analysis of Plasmodium falciparum enoyl-acyl-carrier-protein reductase with Triclosan Analog | 分子名称: | 6-(4-CHLORO-2-HYDROXY-PHENOXY)-NAPHTHALEN-2-OL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, enoyl-acyl carrier reductase | 著者 | Perozzo, R, Kuo, M, Sidhu, A.S, Valiyaveettil, J.T, Bittman, R, Jacobs Jr, W.R, Fidock, D.A, Sacchettini, J.C. | 登録日 | 2003-01-14 | 公開日 | 2003-02-25 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for
Malarial Enoyl Acyl Carrier Protein Reductase J.Biol.Chem., 277, 2002
|
|
1P45
| Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data | 分子名称: | Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN | 著者 | Kuo, M.R, Morbidoni, H.R, Alland, D, Sneddon, S.F, Gourlie, B.B, Staveski, M.M, Leonard, M, Gregory, J.S, Janjigian, A.D, Yee, C, Musser, J.M, Kreiswirth, B.N, Iwamoto, H, Perozzo, R, Jacobs Jr, W.R, Sacchettini, J.C, Fidock, D.A, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2003-04-21 | 公開日 | 2003-09-16 | 最終更新日 | 2019-07-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data. J.Biol.Chem., 278, 2003
|
|
1P44
| Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data | 分子名称: | 5-{[4-(9H-FLUOREN-9-YL)PIPERAZIN-1-YL]CARBONYL}-1H-INDOLE, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Kuo, M.R, Morbidoni, H.R, Alland, D, Sneddon, S.F, Gourlie, B.B, Staveski, M.M, Leonard, M, Gregory, J.S, Janjigian, A.D, Yee, C, Musser, J.M, Kreiswirth, B, Iwamoto, H, Perozzo, R, Jacobs Jr, W.R, Sacchettini, J.C, Fidock, D.A, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2003-04-21 | 公開日 | 2003-09-16 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data. J.Biol.Chem., 278, 2003
|
|
4R67
| Human constitutive 20S proteasome in complex with carfilzomib | 分子名称: | N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-phenylalaninamide, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ... | 著者 | Sacchettini, J.C, Harshbarger, W.H. | 登録日 | 2014-08-22 | 公開日 | 2015-02-11 | 最終更新日 | 2015-02-18 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Crystal Structure of the Human 20S Proteasome in Complex with Carfilzomib. Structure, 23, 2015
|
|
4R3O
| Human Constitutive 20S Proteasome | 分子名称: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... | 著者 | Sacchettini, J.C, Harshbarger, W.H. | 登録日 | 2014-08-16 | 公開日 | 2015-01-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structure of the Human 20S Proteasome in Complex with Carfilzomib. Structure, 23, 2015
|
|
7AZS
| 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569 | 分子名称: | (2R,3S,4R,5R,7S,9S,10S,11R,12S,13R)-12-(((2R,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-2-((S)-1-(((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)-10-(((2S,3R,6R,E)-3-hydroxy-4-(methoxyimino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,5,7,9,11,13-hexamethyl-7-(((2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)carbamoyl)oxy)-6,14-dioxooxacyclotetradecan-4-yl 3-methylbutanoate, 16S rRNA, 23S rRNA, ... | 著者 | Jenner, L.B, Yusupov, M, Yusupova, G, Rak, A. | 登録日 | 2020-11-17 | 公開日 | 2022-06-08 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents. Cell, 186, 2023
|
|
7AZO
| 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977 | 分子名称: | (2R,3S,4R,5R,7S,9S,10S,11R,12S,13R)-12-(((2R,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-2-((S)-1-(((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)-10-(((2S,3R,4R,6R)-3-hydroxy-4-(methoxyamino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,5,7,9,11,13-hexamethyl-7-(((2-((2-nitrophenyl)sulfonamido)ethyl)carbamoyl)oxy)-6,14-dioxooxacyclotetradecan-4-yl 3-methylbutanoate, 16S rRNA, 23S rRNA, ... | 著者 | Jenner, L.B, Yusupov, M, Yusupova, G. | 登録日 | 2020-11-17 | 公開日 | 2022-06-01 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents. Cell, 186, 2023
|
|
6U7A
| Rv3722c in complex with kynurenine | 分子名称: | (2S)-4-(2-aminophenyl)-2-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-4-oxobutanoic acid, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-hydroxyquinoline-2-carboxylic acid, ... | 著者 | Mandyoli, L, Sacchettini, J. | 登録日 | 2019-09-01 | 公開日 | 2020-05-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis. Nat Commun, 11, 2020
|
|
3CBR
| Crystal structure of human Transthyretin (TTR) at pH3.5 | 分子名称: | Transthyretin | 著者 | Mohamedmohaideen, N.N, Palaninathan, S.K, Snee, W.C, Kelly, J.W, C Sacchettini, J. | 登録日 | 2008-02-22 | 公開日 | 2008-08-12 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural insight into pH-induced conformational changes within the native human transthyretin tetramer. J.Mol.Biol., 382, 2008
|
|
4WCW
| Ribosomal silencing factor during starvation or stationary phase (RsfS) from Mycobacterium tuberculosis | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, MAGNESIUM ION, Ribosomal silencing factor RsfS | 著者 | Li, X, Sun, Q, Jiang, C, Yang, K, Hung, L, Zhang, J, Sacchettini, J, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2014-09-05 | 公開日 | 2014-09-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome. Structure, 23, 2015
|
|
5T8G
| |
6H6K
| The structure of the FKR mutant of the archaeal translation initiation factor 2 gamma subunit in complex with GDPCP, obtained in the absence of magnesium salts in the crystallization solution. | 分子名称: | 1,2-ETHANEDIOL, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, SODIUM ION, ... | 著者 | Nikonov, O, Kravchenko, O, Nevskaya, N, Stolboushkina, E, Gabdulkhakov, A, Garber, M, Nikonov, S. | 登録日 | 2018-07-27 | 公開日 | 2019-04-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The third structural switch in the archaeal translation initiation factor 2 (aIF2) molecule and its possible role in the initiation of GTP hydrolysis and the removal of aIF2 from the ribosome. Acta Crystallogr D Struct Biol, 75, 2019
|
|
2GP6
| |
2RHB
| Crystal structure of Nsp15-H234A mutant- Hexamer in asymmetric unit | 分子名称: | Uridylate-specific endoribonuclease | 著者 | Palaninathan, S, Bhardwaj, K, Alcantara, J.M.O, Guarino, L, Yi, L.L, Kao, C.C, Sacchettini, J. | 登録日 | 2007-10-08 | 公開日 | 2007-11-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15. J.Biol.Chem., 283, 2008
|
|
6CYJ
| Mycobacterium tuberculosis transcriptional regulator | 分子名称: | HTH-type transcriptional regulator PrpR, IRON/SULFUR CLUSTER, SUCCINYL-COENZYME A | 著者 | Tang, S, Sacchettini, J. | 登録日 | 2018-04-05 | 公開日 | 2019-04-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.699 Å) | 主引用文献 | Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor. Nucleic Acids Res., 47, 2019
|
|
6CZ6
| Mycobacterium tuberculosis transcriptional regulator | 分子名称: | COENZYME A, HTH-type transcriptional regulator PrpR, IRON/SULFUR CLUSTER | 著者 | Tang, S, Sacchettini, J. | 登録日 | 2018-04-08 | 公開日 | 2019-04-17 | 最終更新日 | 2019-10-30 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor. Nucleic Acids Res., 47, 2019
|
|
6D2S
| |
6CYY
| Mycobacterium tuberculosis transcriptional regulator | 分子名称: | COENZYME A, HTH-type transcriptional regulator PrpR, IRON/SULFUR CLUSTER | 著者 | Tang, S, Sacchettini, J. | 登録日 | 2018-04-07 | 公開日 | 2019-04-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.506 Å) | 主引用文献 | Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor. Nucleic Acids Res., 47, 2019
|
|