7AZO

70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977

Summary for 7AZO

Entry DOI	10.2210/pdb7azo/pdb
Descriptor	16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... (62 entities in total)
Functional Keywords	translation, rna, antibiotics, ribosome
Biological source	Thermus thermophilus HB8 More
Total number of polymer chains	111
Total formula weight	4723583.88
Authors	Jenner, L.B.,Yusupov, M.,Yusupova, G. (deposition date: 2020-11-17, release date: 2022-06-01, Last modification date: 2024-04-24)
Primary citation	Zhang, J.,Lair, C.,Roubert, C.,Amaning, K.,Barrio, M.B.,Benedetti, Y.,Cui, Z.,Xing, Z.,Li, X.,Franzblau, S.G.,Baurin, N.,Bordon-Pallier, F.,Cantalloube, C.,Sans, S.,Silve, S.,Blanc, I.,Fraisse, L.,Rak, A.,Jenner, L.B.,Yusupova, G.,Yusupov, M.,Zhang, J.,Kaneko, T.,Yang, T.J.,Fotouhi, N.,Nuermberger, E.,Tyagi, S.,Betoudji, F.,Upton, A.,Sacchettini, J.C.,Lagrange, S. Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents. Cell, 186:1013-1025.e24, 2023 Cited by PubMed: 36827973 DOI: 10.1016/j.cell.2023.01.043 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation