1P45
Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data
Summary for 1P45
Entry DOI | 10.2210/pdb1p45/pdb |
Related | 1P44 |
Descriptor | Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN, ... (4 entities in total) |
Functional Keywords | inha, short chain dehydrogenase reductase, triclosan, rossmann fold, enoyl-acp reductase, structural genomics, psi, protein structure initiative, tb structural genomics consortium, tbsgc, oxidoreductase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 59305.04 |
Authors | Kuo, M.R.,Morbidoni, H.R.,Alland, D.,Sneddon, S.F.,Gourlie, B.B.,Staveski, M.M.,Leonard, M.,Gregory, J.S.,Janjigian, A.D.,Yee, C.,Musser, J.M.,Kreiswirth, B.N.,Iwamoto, H.,Perozzo, R.,Jacobs Jr., W.R.,Sacchettini, J.C.,Fidock, D.A.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2003-04-21, release date: 2003-09-16, Last modification date: 2019-07-24) |
Primary citation | Kuo, M.R.,Morbidoni, H.R.,Alland, D.,Sneddon, S.F.,Gourlie, B.B.,Staveski, M.M.,Leonard, M.,Gregory, J.S.,Janjigian, A.D.,Yee, C.,Musser, J.M.,Kreiswirth, B.,Iwamoto, H.,Perozzo, R.,Jacobs, W.R.,Sacchettini, J.C.,Fidock, D.A. Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data. J.Biol.Chem., 278:20851-20859, 2003 Cited by PubMed: 12606558DOI: 10.1074/jbc.M211968200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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