7AZS

70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569

This is a non-PDB format compatible entry.

Summary for 7AZS

• Entry DOI: 10.2210/pdb7azs/pdb
• Descriptor: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... (62 entities in total)
• Functional Keywords: translation, rna, antibiotics, ribosome
• Biological source: Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579); More
• Total number of polymer chains: 111
• Total formula weight: 4717500.68

Authors

Jenner, L.B.,Yusupov, M.,Yusupova, G.,Rak, A. (deposition date: 2020-11-17, release date: 2022-06-08, Last modification date: 2024-04-24)

• Primary citation: Zhang, J.,Lair, C.,Roubert, C.,Amaning, K.,Barrio, M.B.,Benedetti, Y.,Cui, Z.,Xing, Z.,Li, X.,Franzblau, S.G.,Baurin, N.,Bordon-Pallier, F.,Cantalloube, C.,Sans, S.,Silve, S.,Blanc, I.,Fraisse, L.,Rak, A.,Jenner, L.B.,Yusupova, G.,Yusupov, M.,Zhang, J.,Kaneko, T.,Yang, T.J.,Fotouhi, N.,Nuermberger, E.,Tyagi, S.,Betoudji, F.,Upton, A.,Sacchettini, J.C.,Lagrange, S.; Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.; Cell, 186:1013-1025.e24, 2023; PubMed: 36827973; DOI: 10.1016/j.cell.2023.01.043

Experimental method

X-RAY DIFFRACTION (3.1 Å)