5T8G
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-oxo-4-((thiophene-2-carbonyl)oxy)butanoic acid
Replaces: 5C9TSummary for 5T8G
| Entry DOI | 10.2210/pdb5t8g/pdb |
| Related | 5C9T |
| Descriptor | Malate synthase G, MAGNESIUM ION, (3E)-2-oxo-4-[(thiophen-2-ylcarbonyl)oxy]but-3-enoic acid, ... (4 entities in total) |
| Functional Keywords | transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| Cellular location | Cytoplasm : P9WK17 |
| Total number of polymer chains | 1 |
| Total formula weight | 80755.85 |
| Authors | Huang, H.-L.,Sacchetiini, J.C. (deposition date: 2016-09-07, release date: 2016-10-26, Last modification date: 2023-10-04) |
| Primary citation | Huang, H.L.,Krieger, I.V.,Parai, M.K.,Gawandi, V.B.,Sacchettini, J.C. Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291:27421-27432, 2016 Cited by PubMed: 27738104DOI: 10.1074/jbc.M116.750877 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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