2RHB

Crystal structure of Nsp15-H234A mutant- Hexamer in asymmetric unit

Summary for 2RHB

• Entry DOI: 10.2210/pdb2rhb/pdb
• Related: 2gth 2h85
• Descriptor: Uridylate-specific endoribonuclease (2 entities in total)
• Functional Keywords: endoribonuclease, sars, hexamer, rna, nsp, viral protein
• Biological source: SARS coronavirus
• Cellular location: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641
• Total number of polymer chains: 6
• Total formula weight: 236554.76

Authors

Palaninathan, S.,Bhardwaj, K.,Alcantara, J.M.O.,Guarino, L.,Yi, L.L.,Kao, C.C.,Sacchettini, J. (deposition date: 2007-10-08, release date: 2007-11-27, Last modification date: 2023-08-30)

• Primary citation: Bhardwaj, K.,Palaninathan, S.,Alcantara, J.M.,Yi, L.L.,Guarino, L.,Sacchettini, J.C.,Kao, C.C.; Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15.; J.Biol.Chem., 283:3655-3664, 2008; PubMed: 18045871; DOI: 10.1074/jbc.M708375200

Experimental method

X-RAY DIFFRACTION (2.8 Å)