4R67

Human constitutive 20S proteasome in complex with carfilzomib

Summary for 4R67

• Entry DOI: 10.2210/pdb4r67/pdb
• Related: 1IRU 1PMA 1RYP 3UNB 3UNE 4R3O
• Related PRD ID: PRD_001243
• Descriptor: Proteasome subunit alpha type-6, Proteasome subunit beta type-3, Proteasome subunit beta type-2, ... (16 entities in total)
• Functional Keywords: hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P60900 P49720 P49721 P28074 P20618 P28070 P25787 P25789 O14818 P28066 P25786 P25788 P28072 Q99436
• Total number of polymer chains: 56
• Total formula weight: 1403757.38

Authors

Sacchettini, J.C.,Harshbarger, W.H. (deposition date: 2014-08-22, release date: 2015-02-11, Last modification date: 2015-02-18)

• Primary citation: Harshbarger, W.,Miller, C.,Diedrich, C.,Sacchettini, J.; Crystal Structure of the Human 20S Proteasome in Complex with Carfilzomib.; Structure, 23:418-424, 2015; PubMed: 25599644; DOI: 10.1016/j.str.2014.11.017

Experimental method

X-RAY DIFFRACTION (2.89 Å)