4R67
Human constitutive 20S proteasome in complex with carfilzomib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, CA, O, QA (A, O, c, q) | Proteasome subunit alpha type-6 | polymer | 244 | 27186.2 | 4 | UniProt (P60900) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | 27 kDa prosomal protein, PROS-27, p27K, Macropain iota chain, Multicatalytic endopeptidase complex iota chain, Proteasome iota chain |
| 2 | B, DA, P, RA (B, P, d, r) | Proteasome subunit alpha type-2 | polymer | 233 | 25796.3 | 4 | UniProt (P25787) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C3, Multicatalytic endopeptidase complex subunit C3, Proteasome component C3 |
| 3 | C, EA, Q, SA (C, Q, e, s) | Proteasome subunit alpha type-4 | polymer | 250 | 28118.2 | 4 | UniProt (P25789) Pfam (PF00227) Pfam (PF10584) | Homo sapiens (human) | Macropain subunit C9, Multicatalytic endopeptidase complex subunit C9, Proteasome component C9, Proteasome subunit L |
| 4 | D, FA, R, TA (D, R, f, t) | Proteasome subunit alpha type-7 | polymer | 243 | 27382.2 | 4 | UniProt (O14818) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Proteasome subunit RC6-1, Proteasome subunit XAPC7 |
| 5 | E, GA, S, UA (E, S, g, u) | Proteasome subunit alpha type-5 | polymer | 234 | 25570.0 | 4 | UniProt (P28066) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain, Proteasome zeta chain |
| 6 | F, HA, T, VA (F, T, h, v) | Proteasome subunit alpha type-1 | polymer | 238 | 26728.4 | 4 | UniProt (P25786) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | 30 kDa prosomal protein, PROS-30, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome component C2, Proteasome nu chain |
| 7 | G, IA, U, WA (G, U, i, w) | Proteasome subunit alpha type-3 | polymer | 245 | 27287.1 | 4 | UniProt (P25788) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C8, Multicatalytic endopeptidase complex subunit C8, Proteasome component C8 |
| 8 | H, JA, V, XA (H, V, j, x) | Proteasome subunit beta type-6 | polymer | 202 | 21656.5 | 4 | UniProt (P28072) Pfam (PF00227) | Homo sapiens (human) | Macropain delta chain, Multicatalytic endopeptidase complex delta chain, Proteasome delta chain, Proteasome subunit Y |
| 9 | I, KA, W, YA (I, W, k, y) | Proteasome subunit beta type-7 | polymer | 220 | 23745.3 | 4 | UniProt (Q99436) Pfam (PF00227) Pfam (PF12465) | Homo sapiens (human) | Macropain chain Z, Multicatalytic endopeptidase complex chain Z, Proteasome subunit Z |
| 10 | J, LA, X, ZA (J, X, l, z) | Proteasome subunit beta type-3 | polymer | 204 | 22841.7 | 4 | UniProt (P49720) Pfam (PF00227) | Homo sapiens (human) | Proteasome chain 13, Proteasome component C10-II, Proteasome theta chain |
| 11 | AB, K, MA, Y (K, Y, m, 0) | Proteasome subunit beta type-2 | polymer | 199 | 22720.1 | 4 | UniProt (P49721) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C7-I, Multicatalytic endopeptidase complex subunit C7-I, Proteasome component C7-I |
| 12 | BB, L, NA, Z (L, Z, n, 3) | Proteasome subunit beta type-5 | polymer | 201 | 22199.1 | 4 | UniProt (P28074) Pfam (PF00227) | Homo sapiens (human) | Macropain epsilon chain, Multicatalytic endopeptidase complex epsilon chain, Proteasome chain 6, Proteasome epsilon chain, Proteasome subunit MB1, Proteasome subunit X |
| 13 | AA, CB, M, OA (M, 1, o, a) | Proteasome subunit beta type-1 | polymer | 213 | 23579.0 | 4 | UniProt (P20618) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C5, Multicatalytic endopeptidase complex subunit C5, Proteasome component C5, Proteasome gamma chain |
| 14 | BA, DB, N, PA (N, 2, p, b) | Proteasome subunit beta type-4 | polymer | 217 | 24138.5 | 4 | UniProt (P28070) Pfam (PF00227) | Homo sapiens (human) | 26 kDa prosomal protein, HsBPROS26, PROS-26, Macropain beta chain, Multicatalytic endopeptidase complex beta chain, Proteasome beta chain, Proteasome chain 3, HsN3 |
| 15 | EB, FB, GB, HB, IB... (H, I, L, V, W...) | N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-phenylalaninamide | non-polymer | 723.9 | 11 | BIRD (PRD_001243) Chemie (3BV) | |||
| 16 | AC, AD, BC, BD, CC... (J, h, K, i, L...) | water | water | 18.0 | 218 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 56 |
| Total formula weight | 1395794.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 7963.4 | |
| All* | Total formula weight | 1403757.4 |
