4R67

Human constitutive 20S proteasome in complex with carfilzomib

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000502	cellular_component	proteasome complex
0	0005515	molecular_function	protein binding
0	0005634	cellular_component	nucleus
0	0005654	cellular_component	nucleoplasm
0	0005737	cellular_component	cytoplasm
0	0005829	cellular_component	cytosol
0	0005839	cellular_component	proteasome core complex
0	0010243	biological_process	response to organonitrogen compound
0	0010498	biological_process	proteasomal protein catabolic process
0	0014070	biological_process	response to organic cyclic compound
0	0016020	cellular_component	membrane
0	0019774	cellular_component	proteasome core complex, beta-subunit complex
0	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
0	0051603	biological_process	proteolysis involved in protein catabolic process
0	0070062	cellular_component	extracellular exosome
1	0005839	cellular_component	proteasome core complex
1	0051603	biological_process	proteolysis involved in protein catabolic process
2	0005839	cellular_component	proteasome core complex
2	0051603	biological_process	proteolysis involved in protein catabolic process
3	0004298	molecular_function	threonine-type endopeptidase activity
3	0005839	cellular_component	proteasome core complex
3	0051603	biological_process	proteolysis involved in protein catabolic process
a	0005839	cellular_component	proteasome core complex
a	0051603	biological_process	proteolysis involved in protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0000932	cellular_component	P-body
A	0003723	molecular_function	RNA binding
A	0004175	molecular_function	endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0005840	cellular_component	ribosome
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0016363	cellular_component	nuclear matrix
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0030016	cellular_component	myofibril
A	0030017	cellular_component	sarcomere
A	0035639	molecular_function	purine ribonucleoside triphosphate binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0050727	biological_process	regulation of inflammatory response
A	0051059	molecular_function	NF-kappaB binding
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0070062	cellular_component	extracellular exosome
b	0005839	cellular_component	proteasome core complex
b	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0000932	cellular_component	P-body
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0009615	biological_process	response to virus
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0034774	cellular_component	secretory granule lumen
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0070062	cellular_component	extracellular exosome
B	1904813	cellular_component	ficolin-1-rich granule lumen
c	0000502	cellular_component	proteasome complex
c	0000932	cellular_component	P-body
c	0003723	molecular_function	RNA binding
c	0004175	molecular_function	endopeptidase activity
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0005839	cellular_component	proteasome core complex
c	0005840	cellular_component	ribosome
c	0006511	biological_process	ubiquitin-dependent protein catabolic process
c	0016363	cellular_component	nuclear matrix
c	0019773	cellular_component	proteasome core complex, alpha-subunit complex
c	0030016	cellular_component	myofibril
c	0030017	cellular_component	sarcomere
c	0035639	molecular_function	purine ribonucleoside triphosphate binding
c	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
c	0050727	biological_process	regulation of inflammatory response
c	0051059	molecular_function	NF-kappaB binding
c	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
c	0051603	biological_process	proteolysis involved in protein catabolic process
c	0070062	cellular_component	extracellular exosome
C	0000502	cellular_component	proteasome complex
C	0000932	cellular_component	P-body
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0070062	cellular_component	extracellular exosome
d	0000502	cellular_component	proteasome complex
d	0000932	cellular_component	P-body
d	0005515	molecular_function	protein binding
d	0005576	cellular_component	extracellular region
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0005839	cellular_component	proteasome core complex
d	0006511	biological_process	ubiquitin-dependent protein catabolic process
d	0009615	biological_process	response to virus
d	0019773	cellular_component	proteasome core complex, alpha-subunit complex
d	0034774	cellular_component	secretory granule lumen
d	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
d	0051603	biological_process	proteolysis involved in protein catabolic process
d	0070062	cellular_component	extracellular exosome
d	1904813	cellular_component	ficolin-1-rich granule lumen
D	0000502	cellular_component	proteasome complex
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0042802	molecular_function	identical protein binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0070062	cellular_component	extracellular exosome
D	0098794	cellular_component	postsynapse
e	0000502	cellular_component	proteasome complex
e	0000932	cellular_component	P-body
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0005839	cellular_component	proteasome core complex
e	0006511	biological_process	ubiquitin-dependent protein catabolic process
e	0019773	cellular_component	proteasome core complex, alpha-subunit complex
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0043231	cellular_component	intracellular membrane-bounded organelle
e	0051603	biological_process	proteolysis involved in protein catabolic process
e	0070062	cellular_component	extracellular exosome
E	0000502	cellular_component	proteasome complex
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0034774	cellular_component	secretory granule lumen
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	0070062	cellular_component	extracellular exosome
E	1904813	cellular_component	ficolin-1-rich granule lumen
f	0000502	cellular_component	proteasome complex
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0005839	cellular_component	proteasome core complex
f	0006511	biological_process	ubiquitin-dependent protein catabolic process
f	0019773	cellular_component	proteasome core complex, alpha-subunit complex
f	0042802	molecular_function	identical protein binding
f	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
f	0051603	biological_process	proteolysis involved in protein catabolic process
f	0070062	cellular_component	extracellular exosome
f	0098794	cellular_component	postsynapse
F	0000502	cellular_component	proteasome complex
F	0001530	molecular_function	lipopolysaccharide binding
F	0002376	biological_process	immune system process
F	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0070062	cellular_component	extracellular exosome
g	0000502	cellular_component	proteasome complex
g	0005515	molecular_function	protein binding
g	0005576	cellular_component	extracellular region
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0005839	cellular_component	proteasome core complex
g	0006511	biological_process	ubiquitin-dependent protein catabolic process
g	0019773	cellular_component	proteasome core complex, alpha-subunit complex
g	0034774	cellular_component	secretory granule lumen
g	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
g	0051603	biological_process	proteolysis involved in protein catabolic process
g	0070062	cellular_component	extracellular exosome
g	1904813	cellular_component	ficolin-1-rich granule lumen
G	0000502	cellular_component	proteasome complex
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0045202	cellular_component	synapse
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	0052548	biological_process	regulation of endopeptidase activity
G	0070062	cellular_component	extracellular exosome
h	0000502	cellular_component	proteasome complex
h	0001530	molecular_function	lipopolysaccharide binding
h	0002376	biological_process	immune system process
h	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005737	cellular_component	cytoplasm
h	0005813	cellular_component	centrosome
h	0005829	cellular_component	cytosol
h	0005839	cellular_component	proteasome core complex
h	0006511	biological_process	ubiquitin-dependent protein catabolic process
h	0019773	cellular_component	proteasome core complex, alpha-subunit complex
h	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
h	0051603	biological_process	proteolysis involved in protein catabolic process
h	0070062	cellular_component	extracellular exosome
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005839	cellular_component	proteasome core complex
H	0051603	biological_process	proteolysis involved in protein catabolic process
i	0000502	cellular_component	proteasome complex
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0005839	cellular_component	proteasome core complex
i	0006511	biological_process	ubiquitin-dependent protein catabolic process
i	0019773	cellular_component	proteasome core complex, alpha-subunit complex
i	0031625	molecular_function	ubiquitin protein ligase binding
i	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
i	0045202	cellular_component	synapse
i	0051603	biological_process	proteolysis involved in protein catabolic process
i	0052548	biological_process	regulation of endopeptidase activity
i	0070062	cellular_component	extracellular exosome
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005839	cellular_component	proteasome core complex
I	0051603	biological_process	proteolysis involved in protein catabolic process
j	0004298	molecular_function	threonine-type endopeptidase activity
j	0005839	cellular_component	proteasome core complex
j	0051603	biological_process	proteolysis involved in protein catabolic process
J	0000502	cellular_component	proteasome complex
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
J	0070062	cellular_component	extracellular exosome
k	0004298	molecular_function	threonine-type endopeptidase activity
k	0005839	cellular_component	proteasome core complex
k	0051603	biological_process	proteolysis involved in protein catabolic process
K	0000502	cellular_component	proteasome complex
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005839	cellular_component	proteasome core complex
K	0010243	biological_process	response to organonitrogen compound
K	0010498	biological_process	proteasomal protein catabolic process
K	0014070	biological_process	response to organic cyclic compound
K	0016020	cellular_component	membrane
K	0019774	cellular_component	proteasome core complex, beta-subunit complex
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0051603	biological_process	proteolysis involved in protein catabolic process
K	0070062	cellular_component	extracellular exosome
l	0000502	cellular_component	proteasome complex
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0005839	cellular_component	proteasome core complex
l	0019774	cellular_component	proteasome core complex, beta-subunit complex
l	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
l	0051603	biological_process	proteolysis involved in protein catabolic process
l	0070062	cellular_component	extracellular exosome
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005839	cellular_component	proteasome core complex
L	0051603	biological_process	proteolysis involved in protein catabolic process
m	0000502	cellular_component	proteasome complex
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0005839	cellular_component	proteasome core complex
m	0010243	biological_process	response to organonitrogen compound
m	0010498	biological_process	proteasomal protein catabolic process
m	0014070	biological_process	response to organic cyclic compound
m	0016020	cellular_component	membrane
m	0019774	cellular_component	proteasome core complex, beta-subunit complex
m	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
m	0051603	biological_process	proteolysis involved in protein catabolic process
m	0070062	cellular_component	extracellular exosome
M	0005839	cellular_component	proteasome core complex
M	0051603	biological_process	proteolysis involved in protein catabolic process
n	0004298	molecular_function	threonine-type endopeptidase activity
n	0005839	cellular_component	proteasome core complex
n	0051603	biological_process	proteolysis involved in protein catabolic process
N	0005839	cellular_component	proteasome core complex
N	0051603	biological_process	proteolysis involved in protein catabolic process
o	0005839	cellular_component	proteasome core complex
o	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0000932	cellular_component	P-body
O	0003723	molecular_function	RNA binding
O	0004175	molecular_function	endopeptidase activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005839	cellular_component	proteasome core complex
O	0005840	cellular_component	ribosome
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0016363	cellular_component	nuclear matrix
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0030016	cellular_component	myofibril
O	0030017	cellular_component	sarcomere
O	0035639	molecular_function	purine ribonucleoside triphosphate binding
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0050727	biological_process	regulation of inflammatory response
O	0051059	molecular_function	NF-kappaB binding
O	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
O	0051603	biological_process	proteolysis involved in protein catabolic process
O	0070062	cellular_component	extracellular exosome
p	0005839	cellular_component	proteasome core complex
p	0051603	biological_process	proteolysis involved in protein catabolic process
P	0000502	cellular_component	proteasome complex
P	0000932	cellular_component	P-body
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0009615	biological_process	response to virus
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0034774	cellular_component	secretory granule lumen
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0051603	biological_process	proteolysis involved in protein catabolic process
P	0070062	cellular_component	extracellular exosome
P	1904813	cellular_component	ficolin-1-rich granule lumen
q	0000502	cellular_component	proteasome complex
q	0000932	cellular_component	P-body
q	0003723	molecular_function	RNA binding
q	0004175	molecular_function	endopeptidase activity
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005737	cellular_component	cytoplasm
q	0005829	cellular_component	cytosol
q	0005839	cellular_component	proteasome core complex
q	0005840	cellular_component	ribosome
q	0006511	biological_process	ubiquitin-dependent protein catabolic process
q	0016363	cellular_component	nuclear matrix
q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
q	0030016	cellular_component	myofibril
q	0030017	cellular_component	sarcomere
q	0035639	molecular_function	purine ribonucleoside triphosphate binding
q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
q	0050727	biological_process	regulation of inflammatory response
q	0051059	molecular_function	NF-kappaB binding
q	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
q	0051603	biological_process	proteolysis involved in protein catabolic process
q	0070062	cellular_component	extracellular exosome
Q	0000502	cellular_component	proteasome complex
Q	0000932	cellular_component	P-body
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0043231	cellular_component	intracellular membrane-bounded organelle
Q	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0070062	cellular_component	extracellular exosome
r	0000502	cellular_component	proteasome complex
r	0000932	cellular_component	P-body
r	0005515	molecular_function	protein binding
r	0005576	cellular_component	extracellular region
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005737	cellular_component	cytoplasm
r	0005829	cellular_component	cytosol
r	0005839	cellular_component	proteasome core complex
r	0006511	biological_process	ubiquitin-dependent protein catabolic process
r	0009615	biological_process	response to virus
r	0019773	cellular_component	proteasome core complex, alpha-subunit complex
r	0034774	cellular_component	secretory granule lumen
r	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
r	0051603	biological_process	proteolysis involved in protein catabolic process
r	0070062	cellular_component	extracellular exosome
r	1904813	cellular_component	ficolin-1-rich granule lumen
R	0000502	cellular_component	proteasome complex
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005839	cellular_component	proteasome core complex
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0042802	molecular_function	identical protein binding
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0051603	biological_process	proteolysis involved in protein catabolic process
R	0070062	cellular_component	extracellular exosome
R	0098794	cellular_component	postsynapse
s	0000502	cellular_component	proteasome complex
s	0000932	cellular_component	P-body
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0005737	cellular_component	cytoplasm
s	0005829	cellular_component	cytosol
s	0005839	cellular_component	proteasome core complex
s	0006511	biological_process	ubiquitin-dependent protein catabolic process
s	0019773	cellular_component	proteasome core complex, alpha-subunit complex
s	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
s	0043231	cellular_component	intracellular membrane-bounded organelle
s	0051603	biological_process	proteolysis involved in protein catabolic process
s	0070062	cellular_component	extracellular exosome
S	0000502	cellular_component	proteasome complex
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005839	cellular_component	proteasome core complex
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0034774	cellular_component	secretory granule lumen
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
S	0070062	cellular_component	extracellular exosome
S	1904813	cellular_component	ficolin-1-rich granule lumen
t	0000502	cellular_component	proteasome complex
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005737	cellular_component	cytoplasm
t	0005829	cellular_component	cytosol
t	0005839	cellular_component	proteasome core complex
t	0006511	biological_process	ubiquitin-dependent protein catabolic process
t	0019773	cellular_component	proteasome core complex, alpha-subunit complex
t	0042802	molecular_function	identical protein binding
t	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
t	0051603	biological_process	proteolysis involved in protein catabolic process
t	0070062	cellular_component	extracellular exosome
t	0098794	cellular_component	postsynapse
T	0000502	cellular_component	proteasome complex
T	0001530	molecular_function	lipopolysaccharide binding
T	0002376	biological_process	immune system process
T	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005813	cellular_component	centrosome
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0051603	biological_process	proteolysis involved in protein catabolic process
T	0070062	cellular_component	extracellular exosome
u	0000502	cellular_component	proteasome complex
u	0005515	molecular_function	protein binding
u	0005576	cellular_component	extracellular region
u	0005634	cellular_component	nucleus
u	0005654	cellular_component	nucleoplasm
u	0005737	cellular_component	cytoplasm
u	0005829	cellular_component	cytosol
u	0005839	cellular_component	proteasome core complex
u	0006511	biological_process	ubiquitin-dependent protein catabolic process
u	0019773	cellular_component	proteasome core complex, alpha-subunit complex
u	0034774	cellular_component	secretory granule lumen
u	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
u	0051603	biological_process	proteolysis involved in protein catabolic process
u	0070062	cellular_component	extracellular exosome
u	1904813	cellular_component	ficolin-1-rich granule lumen
U	0000502	cellular_component	proteasome complex
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005839	cellular_component	proteasome core complex
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0031625	molecular_function	ubiquitin protein ligase binding
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0045202	cellular_component	synapse
U	0051603	biological_process	proteolysis involved in protein catabolic process
U	0052548	biological_process	regulation of endopeptidase activity
U	0070062	cellular_component	extracellular exosome
v	0000502	cellular_component	proteasome complex
v	0001530	molecular_function	lipopolysaccharide binding
v	0002376	biological_process	immune system process
v	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
v	0005515	molecular_function	protein binding
v	0005634	cellular_component	nucleus
v	0005654	cellular_component	nucleoplasm
v	0005737	cellular_component	cytoplasm
v	0005813	cellular_component	centrosome
v	0005829	cellular_component	cytosol
v	0005839	cellular_component	proteasome core complex
v	0006511	biological_process	ubiquitin-dependent protein catabolic process
v	0019773	cellular_component	proteasome core complex, alpha-subunit complex
v	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
v	0051603	biological_process	proteolysis involved in protein catabolic process
v	0070062	cellular_component	extracellular exosome
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005839	cellular_component	proteasome core complex
V	0051603	biological_process	proteolysis involved in protein catabolic process
w	0000502	cellular_component	proteasome complex
w	0005515	molecular_function	protein binding
w	0005634	cellular_component	nucleus
w	0005654	cellular_component	nucleoplasm
w	0005737	cellular_component	cytoplasm
w	0005829	cellular_component	cytosol
w	0005839	cellular_component	proteasome core complex
w	0006511	biological_process	ubiquitin-dependent protein catabolic process
w	0019773	cellular_component	proteasome core complex, alpha-subunit complex
w	0031625	molecular_function	ubiquitin protein ligase binding
w	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
w	0045202	cellular_component	synapse
w	0051603	biological_process	proteolysis involved in protein catabolic process
w	0052548	biological_process	regulation of endopeptidase activity
w	0070062	cellular_component	extracellular exosome
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005839	cellular_component	proteasome core complex
W	0051603	biological_process	proteolysis involved in protein catabolic process
x	0004298	molecular_function	threonine-type endopeptidase activity
x	0005839	cellular_component	proteasome core complex
x	0051603	biological_process	proteolysis involved in protein catabolic process
X	0000502	cellular_component	proteasome complex
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
X	0070062	cellular_component	extracellular exosome
y	0004298	molecular_function	threonine-type endopeptidase activity
y	0005839	cellular_component	proteasome core complex
y	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0000502	cellular_component	proteasome complex
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005839	cellular_component	proteasome core complex
Y	0010243	biological_process	response to organonitrogen compound
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0014070	biological_process	response to organic cyclic compound
Y	0016020	cellular_component	membrane
Y	0019774	cellular_component	proteasome core complex, beta-subunit complex
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0070062	cellular_component	extracellular exosome
z	0000502	cellular_component	proteasome complex
z	0005515	molecular_function	protein binding
z	0005634	cellular_component	nucleus
z	0005654	cellular_component	nucleoplasm
z	0005737	cellular_component	cytoplasm
z	0005829	cellular_component	cytosol
z	0005839	cellular_component	proteasome core complex
z	0019774	cellular_component	proteasome core complex, beta-subunit complex
z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
z	0051603	biological_process	proteolysis involved in protein catabolic process
z	0070062	cellular_component	extracellular exosome
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005839	cellular_component	proteasome core complex
Z	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 3BV H 301

Chain	Residue
H	THR1
H	SER130
H	SER169
H	HOH302
I	TYR114
I	HIS116
H	ARG19
H	THR20
H	THR21
H	THR22
H	ALA27
H	GLY47
H	SER48
H	ALA49

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 3BV I 301

Chain	Residue
I	THR1
I	ARG19
I	ALA20
I	THR21
I	GLU22
I	ALA27
I	LYS33
I	GLY45
I	GLY47
I	ALA49
I	THR52
I	GLY168
I	HOH302
J	GLU106
J	ASP125
J	LEU126
J	ILE127

---

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 3BV L 301

Chain	Residue
L	THR1
L	ARG19
L	ALA20
L	THR21
L	ALA27
L	LYS33
L	MET45
L	GLY47
L	GLY48
L	ALA49
L	SER130
L	TYR169
L	HOH302
L	HOH402
M	ARG100
M	TYR107
M	ASP125
M	PRO126

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 3BV V 301

Chain	Residue
V	THR1
V	ARG19
V	THR20
V	THR21
V	THR22
V	LYS33
V	GLY47
V	ALA49
V	SER130
V	SER169
V	HOH302
W	TYR114
W	HIS116
W	SER118

---

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 3BV W 301

Chain	Residue
W	THR1
W	ARG19
W	THR21
W	GLU22
W	LYS33
W	GLY45
W	GLY47
W	ALA49
W	SER129
W	GLY168
W	HOH302
X	ARG99
X	GLU106
X	ASP125
X	LEU126

---

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 3BV Z 301

Chain	Residue
1	ARG100
1	TYR107
1	ASP125
1	PRO126
Z	THR1
Z	ARG19
Z	ALA20
Z	THR21
Z	MET45
Z	GLY47
Z	ALA49
Z	TYR169
Z	HOH302
Z	HOH403

---

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 3BV j 301

Chain	Residue
j	SER130
j	SER169
j	HOH302
k	TYR114
k	HIS116
k	SER118
j	THR1
j	ARG19
j	THR20
j	THR21
j	LYS33
j	GLY47
j	ALA49

---

site_id	AC8
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 3BV k 301

Chain	Residue
k	THR1
k	ARG19
k	ALA20
k	THR21
k	GLU22
k	LYS33
k	GLY45
k	GLY47
k	THR48
k	ALA49
k	SER129
k	GLY168
k	HOH302
l	GLU106
l	ASP125
l	LEU126
l	ILE127

---

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 3BV n 301

Chain	Residue
n	THR1
n	ARG19
n	ALA20
n	THR21
n	ALA27
n	MET45
n	GLY47
n	ALA49
n	SER130
n	TYR169
n	HOH302
n	HOH404
o	ARG100
o	TYR107
o	ASP125
o	PRO126

---

site_id	BC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 3BV y 301

Chain	Residue
y	THR1
y	ARG19
y	ALA20
y	THR21
y	GLU22
y	ALA27
y	LYS33
y	GLY45
y	GLY47
y	THR48
y	ALA49
y	SER129
y	GLY168
z	MET4
z	ARG99
z	GLU106
z	ASP125
z	LEU126

---

site_id	BC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 3BV 3 301

Chain	Residue
3	THR1
3	ARG19
3	ALA20
3	THR21
3	ALA22
3	LYS33
3	MET45
3	ALA46
3	GLY47
3	ALA49
3	SER130
3	TYR169
3	HOH302
3	HOH406
a	ARG100
a	TYR107
a	ASP125
a	PRO126

---

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdrgvNtFSPeGRlfQVEYAieA

Chain	Residue	Details
E	TYR8-ALA30
D	TYR3-ALA25
G	TYR7-ALA29
B	TYR5-ALA27
C	TYR5-ALA27
F	TYR6-ALA28
A	PHE9-ALA31

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGVkFegGVVIAADmlgsygslarfrnis.RimrvnnstmlgasGdyAD

Chain	Residue	Details
2	LEU12-ASP59
1	LEU13-ASP60
C	LEU35-ASP82
J	MET12-ASP59
I	ALA4-ASP51
3	LEU4-ASP51
0	ILE5-ASP52
H	MET4-ASP51

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455

Chain	Residue	Details
N	TYR57
a	SER34
a	SER40
a	SER134
2	TYR57
p	TYR57
b	TYR57
1	SER40
1	SER134
o	SER34
o	SER40
o	SER134

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:O09061

Chain	Residue	Details
M	TYR122
w	LYS56
w	LYS205
w	LYS229
1	TYR122
o	TYR122
a	TYR122
U	LYS205
U	LYS229
i	LYS56
i	LYS205
i	LYS229

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
M	LYS176
r	SER6
r	SER13
r	SER15
1	LYS176
o	LYS176
a	LYS176
e	LYS127
e	LYS176
s	LYS127
s	LYS176
d	SER15

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
M	SER30
v	LYS115
v	LYS208
M	SER181
1	SER30
1	SER181
o	SER30
o	SER181
a	SER30
a	SER181
h	LYS208

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
E	SER198
S	SER198
g	SER198
u	SER198
d	LYS69
d	LYS170
r	LYS69
r	LYS170

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	TYR75
P	TYR75
d	TYR75
r	TYR75

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P17220

Chain	Residue	Details
B	TYR120
P	TYR120
d	TYR120
r	TYR120

---