4R67

Human constitutive 20S proteasome in complex with carfilzomib

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000502	cellular_component	proteasome complex
0	0002376	biological_process	immune system process
0	0005515	molecular_function	protein binding
0	0005634	cellular_component	nucleus
0	0005654	cellular_component	nucleoplasm
0	0005737	cellular_component	cytoplasm
0	0005829	cellular_component	cytosol
0	0005839	cellular_component	proteasome core complex
0	0006281	biological_process	DNA repair
0	0006915	biological_process	apoptotic process
0	0006974	biological_process	DNA damage response
0	0006979	biological_process	response to oxidative stress
0	0007283	biological_process	spermatogenesis
0	0008021	cellular_component	synaptic vesicle
0	0010498	biological_process	proteasomal protein catabolic process
0	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
0	0016020	cellular_component	membrane
0	0019774	cellular_component	proteasome core complex, beta-subunit complex
0	0030317	biological_process	flagellated sperm motility
0	0032729	biological_process	positive regulation of type II interferon production
0	0032743	biological_process	positive regulation of interleukin-2 production
0	0032760	biological_process	positive regulation of tumor necrosis factor production
0	0034341	biological_process	response to type II interferon
0	0034515	cellular_component	proteasome storage granule
0	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
0	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
0	0045061	biological_process	thymic T cell selection
0	0045063	biological_process	T-helper 1 cell differentiation
0	0045590	biological_process	negative regulation of regulatory T cell differentiation
0	0051321	biological_process	meiotic cell cycle
0	0051603	biological_process	proteolysis involved in protein catabolic process
0	0061136	biological_process	regulation of proteasomal protein catabolic process
0	0070062	cellular_component	extracellular exosome
0	0071357	biological_process	cellular response to type I interferon
0	0072539	biological_process	T-helper 17 cell differentiation
0	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
0	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
1	0005839	cellular_component	proteasome core complex
1	0051603	biological_process	proteolysis involved in protein catabolic process
2	0005839	cellular_component	proteasome core complex
2	0051603	biological_process	proteolysis involved in protein catabolic process
3	0004298	molecular_function	threonine-type endopeptidase activity
3	0005839	cellular_component	proteasome core complex
3	0051603	biological_process	proteolysis involved in protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0000932	cellular_component	P-body
A	0002376	biological_process	immune system process
A	0003723	molecular_function	RNA binding
A	0004175	molecular_function	endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0005840	cellular_component	ribosome
A	0006281	biological_process	DNA repair
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0006979	biological_process	response to oxidative stress
A	0007283	biological_process	spermatogenesis
A	0008021	cellular_component	synaptic vesicle
A	0010498	biological_process	proteasomal protein catabolic process
A	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
A	0016363	cellular_component	nuclear matrix
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0030016	cellular_component	myofibril
A	0030017	cellular_component	sarcomere
A	0030317	biological_process	flagellated sperm motility
A	0032729	biological_process	positive regulation of type II interferon production
A	0032743	biological_process	positive regulation of interleukin-2 production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0034341	biological_process	response to type II interferon
A	0034515	cellular_component	proteasome storage granule
A	0035639	molecular_function	purine ribonucleoside triphosphate binding
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
A	0045061	biological_process	thymic T cell selection
A	0045063	biological_process	T-helper 1 cell differentiation
A	0045590	biological_process	negative regulation of regulatory T cell differentiation
A	0050727	biological_process	regulation of inflammatory response
A	0051059	molecular_function	NF-kappaB binding
A	0051321	biological_process	meiotic cell cycle
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	0070062	cellular_component	extracellular exosome
A	0071357	biological_process	cellular response to type I interferon
A	0072539	biological_process	T-helper 17 cell differentiation
A	0097229	cellular_component	sperm end piece
A	0097542	cellular_component	ciliary tip
A	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
A	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
B	0000502	cellular_component	proteasome complex
B	0000932	cellular_component	P-body
B	0002376	biological_process	immune system process
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006281	biological_process	DNA repair
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006915	biological_process	apoptotic process
B	0006974	biological_process	DNA damage response
B	0006979	biological_process	response to oxidative stress
B	0007283	biological_process	spermatogenesis
B	0008021	cellular_component	synaptic vesicle
B	0009615	biological_process	response to virus
B	0010498	biological_process	proteasomal protein catabolic process
B	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0030317	biological_process	flagellated sperm motility
B	0032729	biological_process	positive regulation of type II interferon production
B	0032743	biological_process	positive regulation of interleukin-2 production
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0034341	biological_process	response to type II interferon
B	0034515	cellular_component	proteasome storage granule
B	0034774	cellular_component	secretory granule lumen
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
B	0045061	biological_process	thymic T cell selection
B	0045063	biological_process	T-helper 1 cell differentiation
B	0045590	biological_process	negative regulation of regulatory T cell differentiation
B	0051321	biological_process	meiotic cell cycle
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0061136	biological_process	regulation of proteasomal protein catabolic process
B	0070062	cellular_component	extracellular exosome
B	0071357	biological_process	cellular response to type I interferon
B	0072539	biological_process	T-helper 17 cell differentiation
B	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
C	0000502	cellular_component	proteasome complex
C	0000932	cellular_component	P-body
C	0002376	biological_process	immune system process
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006281	biological_process	DNA repair
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006915	biological_process	apoptotic process
C	0006974	biological_process	DNA damage response
C	0006979	biological_process	response to oxidative stress
C	0007283	biological_process	spermatogenesis
C	0008021	cellular_component	synaptic vesicle
C	0010498	biological_process	proteasomal protein catabolic process
C	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0030317	biological_process	flagellated sperm motility
C	0032729	biological_process	positive regulation of type II interferon production
C	0032743	biological_process	positive regulation of interleukin-2 production
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0034341	biological_process	response to type II interferon
C	0034515	cellular_component	proteasome storage granule
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
C	0045061	biological_process	thymic T cell selection
C	0045063	biological_process	T-helper 1 cell differentiation
C	0045590	biological_process	negative regulation of regulatory T cell differentiation
C	0051321	biological_process	meiotic cell cycle
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0061136	biological_process	regulation of proteasomal protein catabolic process
C	0070062	cellular_component	extracellular exosome
C	0071357	biological_process	cellular response to type I interferon
C	0072539	biological_process	T-helper 17 cell differentiation
C	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
C	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
D	0000502	cellular_component	proteasome complex
D	0002376	biological_process	immune system process
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006281	biological_process	DNA repair
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006915	biological_process	apoptotic process
D	0006974	biological_process	DNA damage response
D	0006979	biological_process	response to oxidative stress
D	0008021	cellular_component	synaptic vesicle
D	0010498	biological_process	proteasomal protein catabolic process
D	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0030317	biological_process	flagellated sperm motility
D	0032729	biological_process	positive regulation of type II interferon production
D	0032743	biological_process	positive regulation of interleukin-2 production
D	0032760	biological_process	positive regulation of tumor necrosis factor production
D	0034341	biological_process	response to type II interferon
D	0034515	cellular_component	proteasome storage granule
D	0042802	molecular_function	identical protein binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
D	0045061	biological_process	thymic T cell selection
D	0045063	biological_process	T-helper 1 cell differentiation
D	0045590	biological_process	negative regulation of regulatory T cell differentiation
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0061136	biological_process	regulation of proteasomal protein catabolic process
D	0070062	cellular_component	extracellular exosome
D	0071357	biological_process	cellular response to type I interferon
D	0072539	biological_process	T-helper 17 cell differentiation
D	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
D	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
E	0000502	cellular_component	proteasome complex
E	0002376	biological_process	immune system process
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005839	cellular_component	proteasome core complex
E	0006281	biological_process	DNA repair
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006915	biological_process	apoptotic process
E	0006974	biological_process	DNA damage response
E	0006979	biological_process	response to oxidative stress
E	0007283	biological_process	spermatogenesis
E	0008021	cellular_component	synaptic vesicle
E	0010498	biological_process	proteasomal protein catabolic process
E	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0030317	biological_process	flagellated sperm motility
E	0032729	biological_process	positive regulation of type II interferon production
E	0032743	biological_process	positive regulation of interleukin-2 production
E	0032760	biological_process	positive regulation of tumor necrosis factor production
E	0034341	biological_process	response to type II interferon
E	0034515	cellular_component	proteasome storage granule
E	0034774	cellular_component	secretory granule lumen
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
E	0045061	biological_process	thymic T cell selection
E	0045063	biological_process	T-helper 1 cell differentiation
E	0045590	biological_process	negative regulation of regulatory T cell differentiation
E	0051321	biological_process	meiotic cell cycle
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	0061136	biological_process	regulation of proteasomal protein catabolic process
E	0070062	cellular_component	extracellular exosome
E	0071357	biological_process	cellular response to type I interferon
E	0072539	biological_process	T-helper 17 cell differentiation
E	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
E	1904813	cellular_component	ficolin-1-rich granule lumen
E	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
F	0000502	cellular_component	proteasome complex
F	0001530	molecular_function	lipopolysaccharide binding
F	0002376	biological_process	immune system process
F	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0006281	biological_process	DNA repair
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0006915	biological_process	apoptotic process
F	0006974	biological_process	DNA damage response
F	0006979	biological_process	response to oxidative stress
F	0007283	biological_process	spermatogenesis
F	0008021	cellular_component	synaptic vesicle
F	0010498	biological_process	proteasomal protein catabolic process
F	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
F	0016604	cellular_component	nuclear body
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0030317	biological_process	flagellated sperm motility
F	0032729	biological_process	positive regulation of type II interferon production
F	0032743	biological_process	positive regulation of interleukin-2 production
F	0032760	biological_process	positive regulation of tumor necrosis factor production
F	0034341	biological_process	response to type II interferon
F	0034515	cellular_component	proteasome storage granule
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
F	0045061	biological_process	thymic T cell selection
F	0045063	biological_process	T-helper 1 cell differentiation
F	0045590	biological_process	negative regulation of regulatory T cell differentiation
F	0051321	biological_process	meiotic cell cycle
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0061136	biological_process	regulation of proteasomal protein catabolic process
F	0070062	cellular_component	extracellular exosome
F	0071357	biological_process	cellular response to type I interferon
F	0072539	biological_process	T-helper 17 cell differentiation
F	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
F	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
G	0000502	cellular_component	proteasome complex
G	0002376	biological_process	immune system process
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0006281	biological_process	DNA repair
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006915	biological_process	apoptotic process
G	0006974	biological_process	DNA damage response
G	0006979	biological_process	response to oxidative stress
G	0007283	biological_process	spermatogenesis
G	0008021	cellular_component	synaptic vesicle
G	0010498	biological_process	proteasomal protein catabolic process
G	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030317	biological_process	flagellated sperm motility
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032729	biological_process	positive regulation of type II interferon production
G	0032743	biological_process	positive regulation of interleukin-2 production
G	0032760	biological_process	positive regulation of tumor necrosis factor production
G	0034341	biological_process	response to type II interferon
G	0034515	cellular_component	proteasome storage granule
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
G	0045061	biological_process	thymic T cell selection
G	0045063	biological_process	T-helper 1 cell differentiation
G	0045590	biological_process	negative regulation of regulatory T cell differentiation
G	0051321	biological_process	meiotic cell cycle
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	0061136	biological_process	regulation of proteasomal protein catabolic process
G	0070062	cellular_component	extracellular exosome
G	0071357	biological_process	cellular response to type I interferon
G	0072539	biological_process	T-helper 17 cell differentiation
G	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
G	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005839	cellular_component	proteasome core complex
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005839	cellular_component	proteasome core complex
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0000502	cellular_component	proteasome complex
J	0002376	biological_process	immune system process
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0006281	biological_process	DNA repair
J	0006915	biological_process	apoptotic process
J	0006974	biological_process	DNA damage response
J	0006979	biological_process	response to oxidative stress
J	0007283	biological_process	spermatogenesis
J	0008021	cellular_component	synaptic vesicle
J	0010498	biological_process	proteasomal protein catabolic process
J	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0030317	biological_process	flagellated sperm motility
J	0032729	biological_process	positive regulation of type II interferon production
J	0032743	biological_process	positive regulation of interleukin-2 production
J	0032760	biological_process	positive regulation of tumor necrosis factor production
J	0034341	biological_process	response to type II interferon
J	0034515	cellular_component	proteasome storage granule
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
J	0045061	biological_process	thymic T cell selection
J	0045063	biological_process	T-helper 1 cell differentiation
J	0045590	biological_process	negative regulation of regulatory T cell differentiation
J	0051321	biological_process	meiotic cell cycle
J	0051603	biological_process	proteolysis involved in protein catabolic process
J	0061136	biological_process	regulation of proteasomal protein catabolic process
J	0070062	cellular_component	extracellular exosome
J	0071357	biological_process	cellular response to type I interferon
J	0072539	biological_process	T-helper 17 cell differentiation
J	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
J	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
K	0000502	cellular_component	proteasome complex
K	0002376	biological_process	immune system process
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005839	cellular_component	proteasome core complex
K	0006281	biological_process	DNA repair
K	0006915	biological_process	apoptotic process
K	0006974	biological_process	DNA damage response
K	0006979	biological_process	response to oxidative stress
K	0007283	biological_process	spermatogenesis
K	0008021	cellular_component	synaptic vesicle
K	0010498	biological_process	proteasomal protein catabolic process
K	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
K	0016020	cellular_component	membrane
K	0019774	cellular_component	proteasome core complex, beta-subunit complex
K	0030317	biological_process	flagellated sperm motility
K	0032729	biological_process	positive regulation of type II interferon production
K	0032743	biological_process	positive regulation of interleukin-2 production
K	0032760	biological_process	positive regulation of tumor necrosis factor production
K	0034341	biological_process	response to type II interferon
K	0034515	cellular_component	proteasome storage granule
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
K	0045061	biological_process	thymic T cell selection
K	0045063	biological_process	T-helper 1 cell differentiation
K	0045590	biological_process	negative regulation of regulatory T cell differentiation
K	0051321	biological_process	meiotic cell cycle
K	0051603	biological_process	proteolysis involved in protein catabolic process
K	0061136	biological_process	regulation of proteasomal protein catabolic process
K	0070062	cellular_component	extracellular exosome
K	0071357	biological_process	cellular response to type I interferon
K	0072539	biological_process	T-helper 17 cell differentiation
K	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
K	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005839	cellular_component	proteasome core complex
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0005839	cellular_component	proteasome core complex
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0005839	cellular_component	proteasome core complex
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0000932	cellular_component	P-body
O	0002376	biological_process	immune system process
O	0003723	molecular_function	RNA binding
O	0004175	molecular_function	endopeptidase activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005839	cellular_component	proteasome core complex
O	0005840	cellular_component	ribosome
O	0006281	biological_process	DNA repair
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0006915	biological_process	apoptotic process
O	0006974	biological_process	DNA damage response
O	0006979	biological_process	response to oxidative stress
O	0007283	biological_process	spermatogenesis
O	0008021	cellular_component	synaptic vesicle
O	0010498	biological_process	proteasomal protein catabolic process
O	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
O	0016363	cellular_component	nuclear matrix
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0030016	cellular_component	myofibril
O	0030017	cellular_component	sarcomere
O	0030317	biological_process	flagellated sperm motility
O	0032729	biological_process	positive regulation of type II interferon production
O	0032743	biological_process	positive regulation of interleukin-2 production
O	0032760	biological_process	positive regulation of tumor necrosis factor production
O	0034341	biological_process	response to type II interferon
O	0034515	cellular_component	proteasome storage granule
O	0035639	molecular_function	purine ribonucleoside triphosphate binding
O	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
O	0045061	biological_process	thymic T cell selection
O	0045063	biological_process	T-helper 1 cell differentiation
O	0045590	biological_process	negative regulation of regulatory T cell differentiation
O	0050727	biological_process	regulation of inflammatory response
O	0051059	molecular_function	NF-kappaB binding
O	0051321	biological_process	meiotic cell cycle
O	0051603	biological_process	proteolysis involved in protein catabolic process
O	0061136	biological_process	regulation of proteasomal protein catabolic process
O	0070062	cellular_component	extracellular exosome
O	0071357	biological_process	cellular response to type I interferon
O	0072539	biological_process	T-helper 17 cell differentiation
O	0097229	cellular_component	sperm end piece
O	0097542	cellular_component	ciliary tip
O	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
O	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
P	0000502	cellular_component	proteasome complex
P	0000932	cellular_component	P-body
P	0002376	biological_process	immune system process
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
P	0006281	biological_process	DNA repair
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0006915	biological_process	apoptotic process
P	0006974	biological_process	DNA damage response
P	0006979	biological_process	response to oxidative stress
P	0007283	biological_process	spermatogenesis
P	0008021	cellular_component	synaptic vesicle
P	0009615	biological_process	response to virus
P	0010498	biological_process	proteasomal protein catabolic process
P	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0030317	biological_process	flagellated sperm motility
P	0032729	biological_process	positive regulation of type II interferon production
P	0032743	biological_process	positive regulation of interleukin-2 production
P	0032760	biological_process	positive regulation of tumor necrosis factor production
P	0034341	biological_process	response to type II interferon
P	0034515	cellular_component	proteasome storage granule
P	0034774	cellular_component	secretory granule lumen
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
P	0045061	biological_process	thymic T cell selection
P	0045063	biological_process	T-helper 1 cell differentiation
P	0045590	biological_process	negative regulation of regulatory T cell differentiation
P	0051321	biological_process	meiotic cell cycle
P	0051603	biological_process	proteolysis involved in protein catabolic process
P	0061136	biological_process	regulation of proteasomal protein catabolic process
P	0070062	cellular_component	extracellular exosome
P	0071357	biological_process	cellular response to type I interferon
P	0072539	biological_process	T-helper 17 cell differentiation
P	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
P	1904813	cellular_component	ficolin-1-rich granule lumen
P	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
Q	0000502	cellular_component	proteasome complex
Q	0000932	cellular_component	P-body
Q	0002376	biological_process	immune system process
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0006281	biological_process	DNA repair
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0006915	biological_process	apoptotic process
Q	0006974	biological_process	DNA damage response
Q	0006979	biological_process	response to oxidative stress
Q	0007283	biological_process	spermatogenesis
Q	0008021	cellular_component	synaptic vesicle
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0030317	biological_process	flagellated sperm motility
Q	0032729	biological_process	positive regulation of type II interferon production
Q	0032743	biological_process	positive regulation of interleukin-2 production
Q	0032760	biological_process	positive regulation of tumor necrosis factor production
Q	0034341	biological_process	response to type II interferon
Q	0034515	cellular_component	proteasome storage granule
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
Q	0045061	biological_process	thymic T cell selection
Q	0045063	biological_process	T-helper 1 cell differentiation
Q	0045590	biological_process	negative regulation of regulatory T cell differentiation
Q	0051321	biological_process	meiotic cell cycle
Q	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0061136	biological_process	regulation of proteasomal protein catabolic process
Q	0070062	cellular_component	extracellular exosome
Q	0071357	biological_process	cellular response to type I interferon
Q	0072539	biological_process	T-helper 17 cell differentiation
Q	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
Q	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
R	0000502	cellular_component	proteasome complex
R	0002376	biological_process	immune system process
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005839	cellular_component	proteasome core complex
R	0006281	biological_process	DNA repair
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0006915	biological_process	apoptotic process
R	0006974	biological_process	DNA damage response
R	0006979	biological_process	response to oxidative stress
R	0008021	cellular_component	synaptic vesicle
R	0010498	biological_process	proteasomal protein catabolic process
R	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0030317	biological_process	flagellated sperm motility
R	0032729	biological_process	positive regulation of type II interferon production
R	0032743	biological_process	positive regulation of interleukin-2 production
R	0032760	biological_process	positive regulation of tumor necrosis factor production
R	0034341	biological_process	response to type II interferon
R	0034515	cellular_component	proteasome storage granule
R	0042802	molecular_function	identical protein binding
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
R	0045061	biological_process	thymic T cell selection
R	0045063	biological_process	T-helper 1 cell differentiation
R	0045590	biological_process	negative regulation of regulatory T cell differentiation
R	0051603	biological_process	proteolysis involved in protein catabolic process
R	0061136	biological_process	regulation of proteasomal protein catabolic process
R	0070062	cellular_component	extracellular exosome
R	0071357	biological_process	cellular response to type I interferon
R	0072539	biological_process	T-helper 17 cell differentiation
R	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
R	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
S	0000502	cellular_component	proteasome complex
S	0002376	biological_process	immune system process
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S	0005576	cellular_component	extracellular region
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005839	cellular_component	proteasome core complex
S	0006281	biological_process	DNA repair
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0006915	biological_process	apoptotic process
S	0006974	biological_process	DNA damage response
S	0006979	biological_process	response to oxidative stress
S	0007283	biological_process	spermatogenesis
S	0008021	cellular_component	synaptic vesicle
S	0010498	biological_process	proteasomal protein catabolic process
S	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0030317	biological_process	flagellated sperm motility
S	0032729	biological_process	positive regulation of type II interferon production
S	0032743	biological_process	positive regulation of interleukin-2 production
S	0032760	biological_process	positive regulation of tumor necrosis factor production
S	0034341	biological_process	response to type II interferon
S	0034515	cellular_component	proteasome storage granule
S	0034774	cellular_component	secretory granule lumen
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
S	0045061	biological_process	thymic T cell selection
S	0045063	biological_process	T-helper 1 cell differentiation
S	0045590	biological_process	negative regulation of regulatory T cell differentiation
S	0051321	biological_process	meiotic cell cycle
S	0051603	biological_process	proteolysis involved in protein catabolic process
S	0061136	biological_process	regulation of proteasomal protein catabolic process
S	0070062	cellular_component	extracellular exosome
S	0071357	biological_process	cellular response to type I interferon
S	0072539	biological_process	T-helper 17 cell differentiation
S	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
S	1904813	cellular_component	ficolin-1-rich granule lumen
S	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
T	0000502	cellular_component	proteasome complex
T	0001530	molecular_function	lipopolysaccharide binding
T	0002376	biological_process	immune system process
T	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0006281	biological_process	DNA repair
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0006915	biological_process	apoptotic process
T	0006974	biological_process	DNA damage response
T	0006979	biological_process	response to oxidative stress
T	0007283	biological_process	spermatogenesis
T	0008021	cellular_component	synaptic vesicle
T	0010498	biological_process	proteasomal protein catabolic process
T	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
T	0016604	cellular_component	nuclear body
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0030317	biological_process	flagellated sperm motility
T	0032729	biological_process	positive regulation of type II interferon production
T	0032743	biological_process	positive regulation of interleukin-2 production
T	0032760	biological_process	positive regulation of tumor necrosis factor production
T	0034341	biological_process	response to type II interferon
T	0034515	cellular_component	proteasome storage granule
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
T	0045061	biological_process	thymic T cell selection
T	0045063	biological_process	T-helper 1 cell differentiation
T	0045590	biological_process	negative regulation of regulatory T cell differentiation
T	0051321	biological_process	meiotic cell cycle
T	0051603	biological_process	proteolysis involved in protein catabolic process
T	0061136	biological_process	regulation of proteasomal protein catabolic process
T	0070062	cellular_component	extracellular exosome
T	0071357	biological_process	cellular response to type I interferon
T	0072539	biological_process	T-helper 17 cell differentiation
T	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
T	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
U	0000502	cellular_component	proteasome complex
U	0002376	biological_process	immune system process
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005839	cellular_component	proteasome core complex
U	0006281	biological_process	DNA repair
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0006915	biological_process	apoptotic process
U	0006974	biological_process	DNA damage response
U	0006979	biological_process	response to oxidative stress
U	0007283	biological_process	spermatogenesis
U	0008021	cellular_component	synaptic vesicle
U	0010498	biological_process	proteasomal protein catabolic process
U	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0030317	biological_process	flagellated sperm motility
U	0031625	molecular_function	ubiquitin protein ligase binding
U	0032729	biological_process	positive regulation of type II interferon production
U	0032743	biological_process	positive regulation of interleukin-2 production
U	0032760	biological_process	positive regulation of tumor necrosis factor production
U	0034341	biological_process	response to type II interferon
U	0034515	cellular_component	proteasome storage granule
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
U	0045061	biological_process	thymic T cell selection
U	0045063	biological_process	T-helper 1 cell differentiation
U	0045590	biological_process	negative regulation of regulatory T cell differentiation
U	0051321	biological_process	meiotic cell cycle
U	0051603	biological_process	proteolysis involved in protein catabolic process
U	0061136	biological_process	regulation of proteasomal protein catabolic process
U	0070062	cellular_component	extracellular exosome
U	0071357	biological_process	cellular response to type I interferon
U	0072539	biological_process	T-helper 17 cell differentiation
U	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
U	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005839	cellular_component	proteasome core complex
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005839	cellular_component	proteasome core complex
W	0051603	biological_process	proteolysis involved in protein catabolic process
X	0000502	cellular_component	proteasome complex
X	0002376	biological_process	immune system process
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0006281	biological_process	DNA repair
X	0006915	biological_process	apoptotic process
X	0006974	biological_process	DNA damage response
X	0006979	biological_process	response to oxidative stress
X	0007283	biological_process	spermatogenesis
X	0008021	cellular_component	synaptic vesicle
X	0010498	biological_process	proteasomal protein catabolic process
X	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0030317	biological_process	flagellated sperm motility
X	0032729	biological_process	positive regulation of type II interferon production
X	0032743	biological_process	positive regulation of interleukin-2 production
X	0032760	biological_process	positive regulation of tumor necrosis factor production
X	0034341	biological_process	response to type II interferon
X	0034515	cellular_component	proteasome storage granule
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
X	0045061	biological_process	thymic T cell selection
X	0045063	biological_process	T-helper 1 cell differentiation
X	0045590	biological_process	negative regulation of regulatory T cell differentiation
X	0051321	biological_process	meiotic cell cycle
X	0051603	biological_process	proteolysis involved in protein catabolic process
X	0061136	biological_process	regulation of proteasomal protein catabolic process
X	0070062	cellular_component	extracellular exosome
X	0071357	biological_process	cellular response to type I interferon
X	0072539	biological_process	T-helper 17 cell differentiation
X	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
X	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
Y	0000502	cellular_component	proteasome complex
Y	0002376	biological_process	immune system process
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005839	cellular_component	proteasome core complex
Y	0006281	biological_process	DNA repair
Y	0006915	biological_process	apoptotic process
Y	0006974	biological_process	DNA damage response
Y	0006979	biological_process	response to oxidative stress
Y	0007283	biological_process	spermatogenesis
Y	0008021	cellular_component	synaptic vesicle
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
Y	0016020	cellular_component	membrane
Y	0019774	cellular_component	proteasome core complex, beta-subunit complex
Y	0030317	biological_process	flagellated sperm motility
Y	0032729	biological_process	positive regulation of type II interferon production
Y	0032743	biological_process	positive regulation of interleukin-2 production
Y	0032760	biological_process	positive regulation of tumor necrosis factor production
Y	0034341	biological_process	response to type II interferon
Y	0034515	cellular_component	proteasome storage granule
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
Y	0045061	biological_process	thymic T cell selection
Y	0045063	biological_process	T-helper 1 cell differentiation
Y	0045590	biological_process	negative regulation of regulatory T cell differentiation
Y	0051321	biological_process	meiotic cell cycle
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0061136	biological_process	regulation of proteasomal protein catabolic process
Y	0070062	cellular_component	extracellular exosome
Y	0071357	biological_process	cellular response to type I interferon
Y	0072539	biological_process	T-helper 17 cell differentiation
Y	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
Y	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005839	cellular_component	proteasome core complex
Z	0051603	biological_process	proteolysis involved in protein catabolic process
a	0005839	cellular_component	proteasome core complex
a	0051603	biological_process	proteolysis involved in protein catabolic process
b	0005839	cellular_component	proteasome core complex
b	0051603	biological_process	proteolysis involved in protein catabolic process
c	0000502	cellular_component	proteasome complex
c	0000932	cellular_component	P-body
c	0002376	biological_process	immune system process
c	0003723	molecular_function	RNA binding
c	0004175	molecular_function	endopeptidase activity
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0005839	cellular_component	proteasome core complex
c	0005840	cellular_component	ribosome
c	0006281	biological_process	DNA repair
c	0006511	biological_process	ubiquitin-dependent protein catabolic process
c	0006915	biological_process	apoptotic process
c	0006974	biological_process	DNA damage response
c	0006979	biological_process	response to oxidative stress
c	0007283	biological_process	spermatogenesis
c	0008021	cellular_component	synaptic vesicle
c	0010498	biological_process	proteasomal protein catabolic process
c	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
c	0016363	cellular_component	nuclear matrix
c	0019773	cellular_component	proteasome core complex, alpha-subunit complex
c	0030016	cellular_component	myofibril
c	0030017	cellular_component	sarcomere
c	0030317	biological_process	flagellated sperm motility
c	0032729	biological_process	positive regulation of type II interferon production
c	0032743	biological_process	positive regulation of interleukin-2 production
c	0032760	biological_process	positive regulation of tumor necrosis factor production
c	0034341	biological_process	response to type II interferon
c	0034515	cellular_component	proteasome storage granule
c	0035639	molecular_function	purine ribonucleoside triphosphate binding
c	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
c	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
c	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
c	0045061	biological_process	thymic T cell selection
c	0045063	biological_process	T-helper 1 cell differentiation
c	0045590	biological_process	negative regulation of regulatory T cell differentiation
c	0050727	biological_process	regulation of inflammatory response
c	0051059	molecular_function	NF-kappaB binding
c	0051321	biological_process	meiotic cell cycle
c	0051603	biological_process	proteolysis involved in protein catabolic process
c	0061136	biological_process	regulation of proteasomal protein catabolic process
c	0070062	cellular_component	extracellular exosome
c	0071357	biological_process	cellular response to type I interferon
c	0072539	biological_process	T-helper 17 cell differentiation
c	0097229	cellular_component	sperm end piece
c	0097542	cellular_component	ciliary tip
c	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
c	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
d	0000502	cellular_component	proteasome complex
d	0000932	cellular_component	P-body
d	0002376	biological_process	immune system process
d	0005515	molecular_function	protein binding
d	0005576	cellular_component	extracellular region
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0005839	cellular_component	proteasome core complex
d	0006281	biological_process	DNA repair
d	0006511	biological_process	ubiquitin-dependent protein catabolic process
d	0006915	biological_process	apoptotic process
d	0006974	biological_process	DNA damage response
d	0006979	biological_process	response to oxidative stress
d	0007283	biological_process	spermatogenesis
d	0008021	cellular_component	synaptic vesicle
d	0009615	biological_process	response to virus
d	0010498	biological_process	proteasomal protein catabolic process
d	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
d	0019773	cellular_component	proteasome core complex, alpha-subunit complex
d	0030317	biological_process	flagellated sperm motility
d	0032729	biological_process	positive regulation of type II interferon production
d	0032743	biological_process	positive regulation of interleukin-2 production
d	0032760	biological_process	positive regulation of tumor necrosis factor production
d	0034341	biological_process	response to type II interferon
d	0034515	cellular_component	proteasome storage granule
d	0034774	cellular_component	secretory granule lumen
d	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
d	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
d	0045061	biological_process	thymic T cell selection
d	0045063	biological_process	T-helper 1 cell differentiation
d	0045590	biological_process	negative regulation of regulatory T cell differentiation
d	0051321	biological_process	meiotic cell cycle
d	0051603	biological_process	proteolysis involved in protein catabolic process
d	0061136	biological_process	regulation of proteasomal protein catabolic process
d	0070062	cellular_component	extracellular exosome
d	0071357	biological_process	cellular response to type I interferon
d	0072539	biological_process	T-helper 17 cell differentiation
d	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
d	1904813	cellular_component	ficolin-1-rich granule lumen
d	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
e	0000502	cellular_component	proteasome complex
e	0000932	cellular_component	P-body
e	0002376	biological_process	immune system process
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0005839	cellular_component	proteasome core complex
e	0006281	biological_process	DNA repair
e	0006511	biological_process	ubiquitin-dependent protein catabolic process
e	0006915	biological_process	apoptotic process
e	0006974	biological_process	DNA damage response
e	0006979	biological_process	response to oxidative stress
e	0007283	biological_process	spermatogenesis
e	0008021	cellular_component	synaptic vesicle
e	0010498	biological_process	proteasomal protein catabolic process
e	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
e	0019773	cellular_component	proteasome core complex, alpha-subunit complex
e	0030317	biological_process	flagellated sperm motility
e	0032729	biological_process	positive regulation of type II interferon production
e	0032743	biological_process	positive regulation of interleukin-2 production
e	0032760	biological_process	positive regulation of tumor necrosis factor production
e	0034341	biological_process	response to type II interferon
e	0034515	cellular_component	proteasome storage granule
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
e	0045061	biological_process	thymic T cell selection
e	0045063	biological_process	T-helper 1 cell differentiation
e	0045590	biological_process	negative regulation of regulatory T cell differentiation
e	0051321	biological_process	meiotic cell cycle
e	0051603	biological_process	proteolysis involved in protein catabolic process
e	0061136	biological_process	regulation of proteasomal protein catabolic process
e	0070062	cellular_component	extracellular exosome
e	0071357	biological_process	cellular response to type I interferon
e	0072539	biological_process	T-helper 17 cell differentiation
e	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
e	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
f	0000502	cellular_component	proteasome complex
f	0002376	biological_process	immune system process
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0005839	cellular_component	proteasome core complex
f	0006281	biological_process	DNA repair
f	0006511	biological_process	ubiquitin-dependent protein catabolic process
f	0006915	biological_process	apoptotic process
f	0006974	biological_process	DNA damage response
f	0006979	biological_process	response to oxidative stress
f	0008021	cellular_component	synaptic vesicle
f	0010498	biological_process	proteasomal protein catabolic process
f	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
f	0019773	cellular_component	proteasome core complex, alpha-subunit complex
f	0030317	biological_process	flagellated sperm motility
f	0032729	biological_process	positive regulation of type II interferon production
f	0032743	biological_process	positive regulation of interleukin-2 production
f	0032760	biological_process	positive regulation of tumor necrosis factor production
f	0034341	biological_process	response to type II interferon
f	0034515	cellular_component	proteasome storage granule
f	0042802	molecular_function	identical protein binding
f	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
f	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
f	0045061	biological_process	thymic T cell selection
f	0045063	biological_process	T-helper 1 cell differentiation
f	0045590	biological_process	negative regulation of regulatory T cell differentiation
f	0051603	biological_process	proteolysis involved in protein catabolic process
f	0061136	biological_process	regulation of proteasomal protein catabolic process
f	0070062	cellular_component	extracellular exosome
f	0071357	biological_process	cellular response to type I interferon
f	0072539	biological_process	T-helper 17 cell differentiation
f	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
f	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
g	0000502	cellular_component	proteasome complex
g	0002376	biological_process	immune system process
g	0005515	molecular_function	protein binding
g	0005576	cellular_component	extracellular region
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0005839	cellular_component	proteasome core complex
g	0006281	biological_process	DNA repair
g	0006511	biological_process	ubiquitin-dependent protein catabolic process
g	0006915	biological_process	apoptotic process
g	0006974	biological_process	DNA damage response
g	0006979	biological_process	response to oxidative stress
g	0007283	biological_process	spermatogenesis
g	0008021	cellular_component	synaptic vesicle
g	0010498	biological_process	proteasomal protein catabolic process
g	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
g	0019773	cellular_component	proteasome core complex, alpha-subunit complex
g	0030317	biological_process	flagellated sperm motility
g	0032729	biological_process	positive regulation of type II interferon production
g	0032743	biological_process	positive regulation of interleukin-2 production
g	0032760	biological_process	positive regulation of tumor necrosis factor production
g	0034341	biological_process	response to type II interferon
g	0034515	cellular_component	proteasome storage granule
g	0034774	cellular_component	secretory granule lumen
g	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
g	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
g	0045061	biological_process	thymic T cell selection
g	0045063	biological_process	T-helper 1 cell differentiation
g	0045590	biological_process	negative regulation of regulatory T cell differentiation
g	0051321	biological_process	meiotic cell cycle
g	0051603	biological_process	proteolysis involved in protein catabolic process
g	0061136	biological_process	regulation of proteasomal protein catabolic process
g	0070062	cellular_component	extracellular exosome
g	0071357	biological_process	cellular response to type I interferon
g	0072539	biological_process	T-helper 17 cell differentiation
g	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
g	1904813	cellular_component	ficolin-1-rich granule lumen
g	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
h	0000502	cellular_component	proteasome complex
h	0001530	molecular_function	lipopolysaccharide binding
h	0002376	biological_process	immune system process
h	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0005839	cellular_component	proteasome core complex
h	0006281	biological_process	DNA repair
h	0006511	biological_process	ubiquitin-dependent protein catabolic process
h	0006915	biological_process	apoptotic process
h	0006974	biological_process	DNA damage response
h	0006979	biological_process	response to oxidative stress
h	0007283	biological_process	spermatogenesis
h	0008021	cellular_component	synaptic vesicle
h	0010498	biological_process	proteasomal protein catabolic process
h	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
h	0016604	cellular_component	nuclear body
h	0019773	cellular_component	proteasome core complex, alpha-subunit complex
h	0030317	biological_process	flagellated sperm motility
h	0032729	biological_process	positive regulation of type II interferon production
h	0032743	biological_process	positive regulation of interleukin-2 production
h	0032760	biological_process	positive regulation of tumor necrosis factor production
h	0034341	biological_process	response to type II interferon
h	0034515	cellular_component	proteasome storage granule
h	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
h	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
h	0045061	biological_process	thymic T cell selection
h	0045063	biological_process	T-helper 1 cell differentiation
h	0045590	biological_process	negative regulation of regulatory T cell differentiation
h	0051321	biological_process	meiotic cell cycle
h	0051603	biological_process	proteolysis involved in protein catabolic process
h	0061136	biological_process	regulation of proteasomal protein catabolic process
h	0070062	cellular_component	extracellular exosome
h	0071357	biological_process	cellular response to type I interferon
h	0072539	biological_process	T-helper 17 cell differentiation
h	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
h	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
i	0000502	cellular_component	proteasome complex
i	0002376	biological_process	immune system process
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0005839	cellular_component	proteasome core complex
i	0006281	biological_process	DNA repair
i	0006511	biological_process	ubiquitin-dependent protein catabolic process
i	0006915	biological_process	apoptotic process
i	0006974	biological_process	DNA damage response
i	0006979	biological_process	response to oxidative stress
i	0007283	biological_process	spermatogenesis
i	0008021	cellular_component	synaptic vesicle
i	0010498	biological_process	proteasomal protein catabolic process
i	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
i	0019773	cellular_component	proteasome core complex, alpha-subunit complex
i	0030317	biological_process	flagellated sperm motility
i	0031625	molecular_function	ubiquitin protein ligase binding
i	0032729	biological_process	positive regulation of type II interferon production
i	0032743	biological_process	positive regulation of interleukin-2 production
i	0032760	biological_process	positive regulation of tumor necrosis factor production
i	0034341	biological_process	response to type II interferon
i	0034515	cellular_component	proteasome storage granule
i	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
i	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
i	0045061	biological_process	thymic T cell selection
i	0045063	biological_process	T-helper 1 cell differentiation
i	0045590	biological_process	negative regulation of regulatory T cell differentiation
i	0051321	biological_process	meiotic cell cycle
i	0051603	biological_process	proteolysis involved in protein catabolic process
i	0061136	biological_process	regulation of proteasomal protein catabolic process
i	0070062	cellular_component	extracellular exosome
i	0071357	biological_process	cellular response to type I interferon
i	0072539	biological_process	T-helper 17 cell differentiation
i	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
i	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
j	0004298	molecular_function	threonine-type endopeptidase activity
j	0005839	cellular_component	proteasome core complex
j	0051603	biological_process	proteolysis involved in protein catabolic process
k	0004298	molecular_function	threonine-type endopeptidase activity
k	0005839	cellular_component	proteasome core complex
k	0051603	biological_process	proteolysis involved in protein catabolic process
l	0000502	cellular_component	proteasome complex
l	0002376	biological_process	immune system process
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0005839	cellular_component	proteasome core complex
l	0006281	biological_process	DNA repair
l	0006915	biological_process	apoptotic process
l	0006974	biological_process	DNA damage response
l	0006979	biological_process	response to oxidative stress
l	0007283	biological_process	spermatogenesis
l	0008021	cellular_component	synaptic vesicle
l	0010498	biological_process	proteasomal protein catabolic process
l	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
l	0019774	cellular_component	proteasome core complex, beta-subunit complex
l	0030317	biological_process	flagellated sperm motility
l	0032729	biological_process	positive regulation of type II interferon production
l	0032743	biological_process	positive regulation of interleukin-2 production
l	0032760	biological_process	positive regulation of tumor necrosis factor production
l	0034341	biological_process	response to type II interferon
l	0034515	cellular_component	proteasome storage granule
l	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
l	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
l	0045061	biological_process	thymic T cell selection
l	0045063	biological_process	T-helper 1 cell differentiation
l	0045590	biological_process	negative regulation of regulatory T cell differentiation
l	0051321	biological_process	meiotic cell cycle
l	0051603	biological_process	proteolysis involved in protein catabolic process
l	0061136	biological_process	regulation of proteasomal protein catabolic process
l	0070062	cellular_component	extracellular exosome
l	0071357	biological_process	cellular response to type I interferon
l	0072539	biological_process	T-helper 17 cell differentiation
l	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
l	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
m	0000502	cellular_component	proteasome complex
m	0002376	biological_process	immune system process
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0005839	cellular_component	proteasome core complex
m	0006281	biological_process	DNA repair
m	0006915	biological_process	apoptotic process
m	0006974	biological_process	DNA damage response
m	0006979	biological_process	response to oxidative stress
m	0007283	biological_process	spermatogenesis
m	0008021	cellular_component	synaptic vesicle
m	0010498	biological_process	proteasomal protein catabolic process
m	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
m	0016020	cellular_component	membrane
m	0019774	cellular_component	proteasome core complex, beta-subunit complex
m	0030317	biological_process	flagellated sperm motility
m	0032729	biological_process	positive regulation of type II interferon production
m	0032743	biological_process	positive regulation of interleukin-2 production
m	0032760	biological_process	positive regulation of tumor necrosis factor production
m	0034341	biological_process	response to type II interferon
m	0034515	cellular_component	proteasome storage granule
m	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
m	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
m	0045061	biological_process	thymic T cell selection
m	0045063	biological_process	T-helper 1 cell differentiation
m	0045590	biological_process	negative regulation of regulatory T cell differentiation
m	0051321	biological_process	meiotic cell cycle
m	0051603	biological_process	proteolysis involved in protein catabolic process
m	0061136	biological_process	regulation of proteasomal protein catabolic process
m	0070062	cellular_component	extracellular exosome
m	0071357	biological_process	cellular response to type I interferon
m	0072539	biological_process	T-helper 17 cell differentiation
m	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
m	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
n	0004298	molecular_function	threonine-type endopeptidase activity
n	0005839	cellular_component	proteasome core complex
n	0051603	biological_process	proteolysis involved in protein catabolic process
o	0005839	cellular_component	proteasome core complex
o	0051603	biological_process	proteolysis involved in protein catabolic process
p	0005839	cellular_component	proteasome core complex
p	0051603	biological_process	proteolysis involved in protein catabolic process
q	0000502	cellular_component	proteasome complex
q	0000932	cellular_component	P-body
q	0002376	biological_process	immune system process
q	0003723	molecular_function	RNA binding
q	0004175	molecular_function	endopeptidase activity
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005737	cellular_component	cytoplasm
q	0005829	cellular_component	cytosol
q	0005839	cellular_component	proteasome core complex
q	0005840	cellular_component	ribosome
q	0006281	biological_process	DNA repair
q	0006511	biological_process	ubiquitin-dependent protein catabolic process
q	0006915	biological_process	apoptotic process
q	0006974	biological_process	DNA damage response
q	0006979	biological_process	response to oxidative stress
q	0007283	biological_process	spermatogenesis
q	0008021	cellular_component	synaptic vesicle
q	0010498	biological_process	proteasomal protein catabolic process
q	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
q	0016363	cellular_component	nuclear matrix
q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
q	0030016	cellular_component	myofibril
q	0030017	cellular_component	sarcomere
q	0030317	biological_process	flagellated sperm motility
q	0032729	biological_process	positive regulation of type II interferon production
q	0032743	biological_process	positive regulation of interleukin-2 production
q	0032760	biological_process	positive regulation of tumor necrosis factor production
q	0034341	biological_process	response to type II interferon
q	0034515	cellular_component	proteasome storage granule
q	0035639	molecular_function	purine ribonucleoside triphosphate binding
q	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
q	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
q	0045061	biological_process	thymic T cell selection
q	0045063	biological_process	T-helper 1 cell differentiation
q	0045590	biological_process	negative regulation of regulatory T cell differentiation
q	0050727	biological_process	regulation of inflammatory response
q	0051059	molecular_function	NF-kappaB binding
q	0051321	biological_process	meiotic cell cycle
q	0051603	biological_process	proteolysis involved in protein catabolic process
q	0061136	biological_process	regulation of proteasomal protein catabolic process
q	0070062	cellular_component	extracellular exosome
q	0071357	biological_process	cellular response to type I interferon
q	0072539	biological_process	T-helper 17 cell differentiation
q	0097229	cellular_component	sperm end piece
q	0097542	cellular_component	ciliary tip
q	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
q	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
r	0000502	cellular_component	proteasome complex
r	0000932	cellular_component	P-body
r	0002376	biological_process	immune system process
r	0005515	molecular_function	protein binding
r	0005576	cellular_component	extracellular region
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005737	cellular_component	cytoplasm
r	0005829	cellular_component	cytosol
r	0005839	cellular_component	proteasome core complex
r	0006281	biological_process	DNA repair
r	0006511	biological_process	ubiquitin-dependent protein catabolic process
r	0006915	biological_process	apoptotic process
r	0006974	biological_process	DNA damage response
r	0006979	biological_process	response to oxidative stress
r	0007283	biological_process	spermatogenesis
r	0008021	cellular_component	synaptic vesicle
r	0009615	biological_process	response to virus
r	0010498	biological_process	proteasomal protein catabolic process
r	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
r	0019773	cellular_component	proteasome core complex, alpha-subunit complex
r	0030317	biological_process	flagellated sperm motility
r	0032729	biological_process	positive regulation of type II interferon production
r	0032743	biological_process	positive regulation of interleukin-2 production
r	0032760	biological_process	positive regulation of tumor necrosis factor production
r	0034341	biological_process	response to type II interferon
r	0034515	cellular_component	proteasome storage granule
r	0034774	cellular_component	secretory granule lumen
r	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
r	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
r	0045061	biological_process	thymic T cell selection
r	0045063	biological_process	T-helper 1 cell differentiation
r	0045590	biological_process	negative regulation of regulatory T cell differentiation
r	0051321	biological_process	meiotic cell cycle
r	0051603	biological_process	proteolysis involved in protein catabolic process
r	0061136	biological_process	regulation of proteasomal protein catabolic process
r	0070062	cellular_component	extracellular exosome
r	0071357	biological_process	cellular response to type I interferon
r	0072539	biological_process	T-helper 17 cell differentiation
r	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
r	1904813	cellular_component	ficolin-1-rich granule lumen
r	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
s	0000502	cellular_component	proteasome complex
s	0000932	cellular_component	P-body
s	0002376	biological_process	immune system process
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0005737	cellular_component	cytoplasm
s	0005829	cellular_component	cytosol
s	0005839	cellular_component	proteasome core complex
s	0006281	biological_process	DNA repair
s	0006511	biological_process	ubiquitin-dependent protein catabolic process
s	0006915	biological_process	apoptotic process
s	0006974	biological_process	DNA damage response
s	0006979	biological_process	response to oxidative stress
s	0007283	biological_process	spermatogenesis
s	0008021	cellular_component	synaptic vesicle
s	0010498	biological_process	proteasomal protein catabolic process
s	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
s	0019773	cellular_component	proteasome core complex, alpha-subunit complex
s	0030317	biological_process	flagellated sperm motility
s	0032729	biological_process	positive regulation of type II interferon production
s	0032743	biological_process	positive regulation of interleukin-2 production
s	0032760	biological_process	positive regulation of tumor necrosis factor production
s	0034341	biological_process	response to type II interferon
s	0034515	cellular_component	proteasome storage granule
s	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
s	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
s	0045061	biological_process	thymic T cell selection
s	0045063	biological_process	T-helper 1 cell differentiation
s	0045590	biological_process	negative regulation of regulatory T cell differentiation
s	0051321	biological_process	meiotic cell cycle
s	0051603	biological_process	proteolysis involved in protein catabolic process
s	0061136	biological_process	regulation of proteasomal protein catabolic process
s	0070062	cellular_component	extracellular exosome
s	0071357	biological_process	cellular response to type I interferon
s	0072539	biological_process	T-helper 17 cell differentiation
s	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
s	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
t	0000502	cellular_component	proteasome complex
t	0002376	biological_process	immune system process
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005737	cellular_component	cytoplasm
t	0005829	cellular_component	cytosol
t	0005839	cellular_component	proteasome core complex
t	0006281	biological_process	DNA repair
t	0006511	biological_process	ubiquitin-dependent protein catabolic process
t	0006915	biological_process	apoptotic process
t	0006974	biological_process	DNA damage response
t	0006979	biological_process	response to oxidative stress
t	0008021	cellular_component	synaptic vesicle
t	0010498	biological_process	proteasomal protein catabolic process
t	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
t	0019773	cellular_component	proteasome core complex, alpha-subunit complex
t	0030317	biological_process	flagellated sperm motility
t	0032729	biological_process	positive regulation of type II interferon production
t	0032743	biological_process	positive regulation of interleukin-2 production
t	0032760	biological_process	positive regulation of tumor necrosis factor production
t	0034341	biological_process	response to type II interferon
t	0034515	cellular_component	proteasome storage granule
t	0042802	molecular_function	identical protein binding
t	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
t	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
t	0045061	biological_process	thymic T cell selection
t	0045063	biological_process	T-helper 1 cell differentiation
t	0045590	biological_process	negative regulation of regulatory T cell differentiation
t	0051603	biological_process	proteolysis involved in protein catabolic process
t	0061136	biological_process	regulation of proteasomal protein catabolic process
t	0070062	cellular_component	extracellular exosome
t	0071357	biological_process	cellular response to type I interferon
t	0072539	biological_process	T-helper 17 cell differentiation
t	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
t	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
u	0000502	cellular_component	proteasome complex
u	0002376	biological_process	immune system process
u	0005515	molecular_function	protein binding
u	0005576	cellular_component	extracellular region
u	0005634	cellular_component	nucleus
u	0005654	cellular_component	nucleoplasm
u	0005737	cellular_component	cytoplasm
u	0005829	cellular_component	cytosol
u	0005839	cellular_component	proteasome core complex
u	0006281	biological_process	DNA repair
u	0006511	biological_process	ubiquitin-dependent protein catabolic process
u	0006915	biological_process	apoptotic process
u	0006974	biological_process	DNA damage response
u	0006979	biological_process	response to oxidative stress
u	0007283	biological_process	spermatogenesis
u	0008021	cellular_component	synaptic vesicle
u	0010498	biological_process	proteasomal protein catabolic process
u	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
u	0019773	cellular_component	proteasome core complex, alpha-subunit complex
u	0030317	biological_process	flagellated sperm motility
u	0032729	biological_process	positive regulation of type II interferon production
u	0032743	biological_process	positive regulation of interleukin-2 production
u	0032760	biological_process	positive regulation of tumor necrosis factor production
u	0034341	biological_process	response to type II interferon
u	0034515	cellular_component	proteasome storage granule
u	0034774	cellular_component	secretory granule lumen
u	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
u	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
u	0045061	biological_process	thymic T cell selection
u	0045063	biological_process	T-helper 1 cell differentiation
u	0045590	biological_process	negative regulation of regulatory T cell differentiation
u	0051321	biological_process	meiotic cell cycle
u	0051603	biological_process	proteolysis involved in protein catabolic process
u	0061136	biological_process	regulation of proteasomal protein catabolic process
u	0070062	cellular_component	extracellular exosome
u	0071357	biological_process	cellular response to type I interferon
u	0072539	biological_process	T-helper 17 cell differentiation
u	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
u	1904813	cellular_component	ficolin-1-rich granule lumen
u	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
v	0000502	cellular_component	proteasome complex
v	0001530	molecular_function	lipopolysaccharide binding
v	0002376	biological_process	immune system process
v	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
v	0005515	molecular_function	protein binding
v	0005634	cellular_component	nucleus
v	0005654	cellular_component	nucleoplasm
v	0005737	cellular_component	cytoplasm
v	0005829	cellular_component	cytosol
v	0005839	cellular_component	proteasome core complex
v	0006281	biological_process	DNA repair
v	0006511	biological_process	ubiquitin-dependent protein catabolic process
v	0006915	biological_process	apoptotic process
v	0006974	biological_process	DNA damage response
v	0006979	biological_process	response to oxidative stress
v	0007283	biological_process	spermatogenesis
v	0008021	cellular_component	synaptic vesicle
v	0010498	biological_process	proteasomal protein catabolic process
v	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
v	0016604	cellular_component	nuclear body
v	0019773	cellular_component	proteasome core complex, alpha-subunit complex
v	0030317	biological_process	flagellated sperm motility
v	0032729	biological_process	positive regulation of type II interferon production
v	0032743	biological_process	positive regulation of interleukin-2 production
v	0032760	biological_process	positive regulation of tumor necrosis factor production
v	0034341	biological_process	response to type II interferon
v	0034515	cellular_component	proteasome storage granule
v	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
v	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
v	0045061	biological_process	thymic T cell selection
v	0045063	biological_process	T-helper 1 cell differentiation
v	0045590	biological_process	negative regulation of regulatory T cell differentiation
v	0051321	biological_process	meiotic cell cycle
v	0051603	biological_process	proteolysis involved in protein catabolic process
v	0061136	biological_process	regulation of proteasomal protein catabolic process
v	0070062	cellular_component	extracellular exosome
v	0071357	biological_process	cellular response to type I interferon
v	0072539	biological_process	T-helper 17 cell differentiation
v	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
v	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
w	0000502	cellular_component	proteasome complex
w	0002376	biological_process	immune system process
w	0005515	molecular_function	protein binding
w	0005634	cellular_component	nucleus
w	0005654	cellular_component	nucleoplasm
w	0005737	cellular_component	cytoplasm
w	0005829	cellular_component	cytosol
w	0005839	cellular_component	proteasome core complex
w	0006281	biological_process	DNA repair
w	0006511	biological_process	ubiquitin-dependent protein catabolic process
w	0006915	biological_process	apoptotic process
w	0006974	biological_process	DNA damage response
w	0006979	biological_process	response to oxidative stress
w	0007283	biological_process	spermatogenesis
w	0008021	cellular_component	synaptic vesicle
w	0010498	biological_process	proteasomal protein catabolic process
w	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
w	0019773	cellular_component	proteasome core complex, alpha-subunit complex
w	0030317	biological_process	flagellated sperm motility
w	0031625	molecular_function	ubiquitin protein ligase binding
w	0032729	biological_process	positive regulation of type II interferon production
w	0032743	biological_process	positive regulation of interleukin-2 production
w	0032760	biological_process	positive regulation of tumor necrosis factor production
w	0034341	biological_process	response to type II interferon
w	0034515	cellular_component	proteasome storage granule
w	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
w	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
w	0045061	biological_process	thymic T cell selection
w	0045063	biological_process	T-helper 1 cell differentiation
w	0045590	biological_process	negative regulation of regulatory T cell differentiation
w	0051321	biological_process	meiotic cell cycle
w	0051603	biological_process	proteolysis involved in protein catabolic process
w	0061136	biological_process	regulation of proteasomal protein catabolic process
w	0070062	cellular_component	extracellular exosome
w	0071357	biological_process	cellular response to type I interferon
w	0072539	biological_process	T-helper 17 cell differentiation
w	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
w	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
x	0004298	molecular_function	threonine-type endopeptidase activity
x	0005839	cellular_component	proteasome core complex
x	0051603	biological_process	proteolysis involved in protein catabolic process
y	0004298	molecular_function	threonine-type endopeptidase activity
y	0005839	cellular_component	proteasome core complex
y	0051603	biological_process	proteolysis involved in protein catabolic process
z	0000502	cellular_component	proteasome complex
z	0002376	biological_process	immune system process
z	0005515	molecular_function	protein binding
z	0005634	cellular_component	nucleus
z	0005654	cellular_component	nucleoplasm
z	0005737	cellular_component	cytoplasm
z	0005829	cellular_component	cytosol
z	0005839	cellular_component	proteasome core complex
z	0006281	biological_process	DNA repair
z	0006915	biological_process	apoptotic process
z	0006974	biological_process	DNA damage response
z	0006979	biological_process	response to oxidative stress
z	0007283	biological_process	spermatogenesis
z	0008021	cellular_component	synaptic vesicle
z	0010498	biological_process	proteasomal protein catabolic process
z	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
z	0019774	cellular_component	proteasome core complex, beta-subunit complex
z	0030317	biological_process	flagellated sperm motility
z	0032729	biological_process	positive regulation of type II interferon production
z	0032743	biological_process	positive regulation of interleukin-2 production
z	0032760	biological_process	positive regulation of tumor necrosis factor production
z	0034341	biological_process	response to type II interferon
z	0034515	cellular_component	proteasome storage granule
z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
z	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
z	0045061	biological_process	thymic T cell selection
z	0045063	biological_process	T-helper 1 cell differentiation
z	0045590	biological_process	negative regulation of regulatory T cell differentiation
z	0051321	biological_process	meiotic cell cycle
z	0051603	biological_process	proteolysis involved in protein catabolic process
z	0061136	biological_process	regulation of proteasomal protein catabolic process
z	0070062	cellular_component	extracellular exosome
z	0071357	biological_process	cellular response to type I interferon
z	0072539	biological_process	T-helper 17 cell differentiation
z	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
z	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 3BV H 301

Chain	Residue
H	THR1
H	SER130
H	SER169
H	HOH302
I	TYR114
I	HIS116
H	ARG19
H	THR20
H	THR21
H	THR22
H	ALA27
H	GLY47
H	SER48
H	ALA49

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 3BV I 301

Chain	Residue
I	THR1
I	ARG19
I	ALA20
I	THR21
I	GLU22
I	ALA27
I	LYS33
I	GLY45
I	GLY47
I	ALA49
I	THR52
I	GLY168
I	HOH302
J	GLU106
J	ASP125
J	LEU126
J	ILE127

---

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 3BV L 301

Chain	Residue
L	THR1
L	ARG19
L	ALA20
L	THR21
L	ALA27
L	LYS33
L	MET45
L	GLY47
L	GLY48
L	ALA49
L	SER130
L	TYR169
L	HOH302
L	HOH402
M	ARG100
M	TYR107
M	ASP125
M	PRO126

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 3BV V 301

Chain	Residue
V	THR1
V	ARG19
V	THR20
V	THR21
V	THR22
V	LYS33
V	GLY47
V	ALA49
V	SER130
V	SER169
V	HOH302
W	TYR114
W	HIS116
W	SER118

---

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 3BV W 301

Chain	Residue
W	THR1
W	ARG19
W	THR21
W	GLU22
W	LYS33
W	GLY45
W	GLY47
W	ALA49
W	SER129
W	GLY168
W	HOH302
X	ARG99
X	GLU106
X	ASP125
X	LEU126

---

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 3BV Z 301

Chain	Residue
1	ARG100
1	TYR107
1	ASP125
1	PRO126
Z	THR1
Z	ARG19
Z	ALA20
Z	THR21
Z	MET45
Z	GLY47
Z	ALA49
Z	TYR169
Z	HOH302
Z	HOH403

---

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 3BV j 301

Chain	Residue
j	SER130
j	SER169
j	HOH302
k	TYR114
k	HIS116
k	SER118
j	THR1
j	ARG19
j	THR20
j	THR21
j	LYS33
j	GLY47
j	ALA49

---

site_id	AC8
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 3BV k 301

Chain	Residue
k	THR1
k	ARG19
k	ALA20
k	THR21
k	GLU22
k	LYS33
k	GLY45
k	GLY47
k	THR48
k	ALA49
k	SER129
k	GLY168
k	HOH302
l	GLU106
l	ASP125
l	LEU126
l	ILE127

---

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 3BV n 301

Chain	Residue
n	THR1
n	ARG19
n	ALA20
n	THR21
n	ALA27
n	MET45
n	GLY47
n	ALA49
n	SER130
n	TYR169
n	HOH302
n	HOH404
o	ARG100
o	TYR107
o	ASP125
o	PRO126

---

site_id	BC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 3BV y 301

Chain	Residue
y	THR1
y	ARG19
y	ALA20
y	THR21
y	GLU22
y	ALA27
y	LYS33
y	GLY45
y	GLY47
y	THR48
y	ALA49
y	SER129
y	GLY168
z	MET4
z	ARG99
z	GLU106
z	ASP125
z	LEU126

---

site_id	BC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 3BV 3 301

Chain	Residue
3	THR1
3	ARG19
3	ALA20
3	THR21
3	ALA22
3	LYS33
3	MET45
3	ALA46
3	GLY47
3	ALA49
3	SER130
3	TYR169
3	HOH302
3	HOH406
a	ARG100
a	TYR107
a	ASP125
a	PRO126

---

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdndvTvWSPqGRihQIEYAmeA

Chain	Residue	Details
F	TYR6-ALA28
E	TYR8-ALA30
G	TYR7-ALA29
C	TYR5-ALA27
D	TYR3-ALA25
B	TYR5-ALA27
A	PHE9-ALA31

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGVkFegGVVIAADmlgsygslarfrnis.RimrvnnstmlgasGdyAD

Chain	Residue	Details
2	LEU12-ASP59
I	ALA4-ASP51
0	ILE5-ASP52
3	LEU4-ASP51
C	LEU35-ASP82
H	MET4-ASP51
J	MET12-ASP59
1	LEU13-ASP60

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9QUM9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P49722","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P17220","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by ABL1 and ABL2","evidences":[{"source":"PubMed","id":"16678104","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; alternate","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine; alternate","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"12376572","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	12
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"25599644","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27493187","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	4
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","von Kriegsheim A.F.","Kolch W."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	4
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18502982","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18565852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19426847","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O09061","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---