1NNU

Crystal Structure Analysis of Plasmodium falciparum enoyl-acyl-carrier-protein reductase with Triclosan Analog

Summary for 1NNU

Entry DOI	10.2210/pdb1nnu/pdb
Related	1NHD 1NHG 1NHW
Descriptor	enoyl-acyl carrier reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 6-(4-CHLORO-2-HYDROXY-PHENOXY)-NAPHTHALEN-2-OL, ... (4 entities in total)
Functional Keywords	rossmann fold, nadh, short chain dehydrogenase reductase, oxidoreductase
Biological source	Plasmodium falciparum (malaria parasite P. falciparum) More
Total number of polymer chains	4
Total formula weight	67048.76
Authors	Perozzo, R.,Kuo, M.,Sidhu, A.S.,Valiyaveettil, J.T.,Bittman, R.,Jacobs Jr., W.R.,Fidock, D.A.,Sacchettini, J.C. (deposition date: 2003-01-14, release date: 2003-02-25, Last modification date: 2024-02-14)
Primary citation	Perozzo, R.,Kuo, M.,Sidhu, A.S.,Valiyaveettil, J.T.,Bittman, R.,Jacobs Jr., W.R.,Fidock, D.A.,Sacchettini, J.C. Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for Malarial Enoyl Acyl Carrier Protein Reductase J.Biol.Chem., 277:13106-13114, 2002 Cited by PubMed: 11792710 DOI: 10.1074/jbc.M112000200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation