4NKK
 
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6B6I
 | | 2.4A resolution structure of human Norovirus GII.4 protease | | 分子名称: | 3C-like protease | | 著者 | Muzzarelli, K.M, Kuiper, B.D, Spellmon, N.S, Hackett, J, Brunzelle, J.S, Kovari, I.A, Amblard, F, Yang, Z, Schinazi, R.F, Kovari, L.C. | | 登録日 | 2017-10-02 | | 公開日 | 2018-10-03 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Structural and Antiviral Studies of the Human Norovirus GII.4 Protease.
Biochemistry, 58, 2019
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4FAF
 | | Substrate CA/p2 in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant | | 分子名称: | HIV-1 protease, substrate CA/p2 peptide | | 著者 | Wang, Y, Dewdney, T.G, Liu, Z, Reiter, S.J, Brunzelle, J.S, Kovari, I.A, Kovari, L.C. | | 登録日 | 2012-05-22 | | 公開日 | 2012-08-29 | | 最終更新日 | 2023-07-26 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Higher Desolvation Energy Reduces Molecular Recognition in Multi-Drug Resistant HIV-1 Protease.
Biology (Basel), 1, 2012
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4YOA
 | | Crsystal structure HIV-1 Protease MDR769 L33F Complexed with darunavir | | 分子名称: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, HIV-1 Protease | | 著者 | Kuiper, B.D, Keusch, B, Dewdney, T.G, Chordia, P, Brunzelle, J.S, Ross, K, Kovari, I.A, MacArthur, R, Salimnia, H, Kovari, L.C. | | 登録日 | 2015-03-11 | | 公開日 | 2015-07-08 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.697 Å) | | 主引用文献 | The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops.
Biochem Biophys Rep, 2, 2015
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4YOB
 | | Crystal Structure of Apo HIV-1 Protease MDR769 L33F | | 分子名称: | HIV-1 Protease | | 著者 | Kuiper, B.D, Keusch, B, Dewdney, T.G, Chordia, P, Ross, K, Brunzelle, J.S, Kovari, I.A, MacArthur, R, Salimnia, H, Kovari, L.C. | | 登録日 | 2015-03-11 | | 公開日 | 2015-07-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.504 Å) | | 主引用文献 | The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops.
Biochem Biophys Rep, 2, 2015
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1AFV
 | | HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3 | | 分子名称: | ANTIBODY FAB25.3 FRAGMENT (HEAVY CHAIN), ANTIBODY FAB25.3 FRAGMENT (LIGHT CHAIN), HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 CAPSID PROTEIN, ... | | 著者 | Momany, C, Kovari, L.C, Prongay, A.J, Keller, W, Gitti, R.K, Lee, B.M, Gorbalenya, A.E, Tong, L, Mcclure, J, Ehrlich, L.S, Summers, M.F, Carter, C, Rossmann, M.G. | | 登録日 | 1997-03-14 | | 公開日 | 1997-08-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Crystal structure of dimeric HIV-1 capsid protein.
Nat.Struct.Biol., 3, 1996
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4EYR
 | | Crystal structure of multidrug-resistant clinical isolate 769 HIV-1 protease in complex with ritonavir | | 分子名称: | HIV-1 PROTEASE, RITONAVIR | | 著者 | Liu, Z, Yedidi, R.S, Wang, Y, Brunzelle, J.S, Kovari, I.A, Kovari, L.C. | | 登録日 | 2012-05-01 | | 公開日 | 2013-01-30 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex.
Biochem.Biophys.Res.Commun., 431, 2013
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4FAE
 | | Substrate p2/NC in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant | | 分子名称: | HIV-1 protease, Substrate p2/NC peptide | | 著者 | Wang, Y, Dewdney, T.G, Liu, Z, Reiter, S.J, Brunzelle, J.S, Kovari, I.A, Kovari, L.C. | | 登録日 | 2012-05-22 | | 公開日 | 2012-08-29 | | 最終更新日 | 2023-07-26 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Higher Desolvation Energy Reduces Molecular Recognition in Multi-Drug Resistant HIV-1 Protease.
Biology (Basel), 1, 2012
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4GYE
 | | MDR 769 HIV-1 Protease in Complex with Reduced P1F | | 分子名称: | P1F peptide, Protease | | 著者 | Dewdney, T.G, Wang, Y, Brunzelle, J, Reiter, S.J, Kovari, I.A, Kovari, L.C. | | 登録日 | 2012-09-05 | | 公開日 | 2013-10-30 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease.
Bioorg.Med.Chem., 21, 2013
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4GZF
 | | Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide | | 分子名称: | LrF peptide, Protease | | 著者 | Dewdney, T.G, Wang, Y, Kovari, I.A, Brunzelle, J.S, Reiter, S.J, Kovari, L.C. | | 登録日 | 2012-09-06 | | 公開日 | 2013-10-30 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease.
Bioorg.Med.Chem., 21, 2013
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3OAI
 | | Crystal structure of the extra-cellular domain of human myelin protein zero | | 分子名称: | Maltose-binding periplasmic protein, Myelin protein P0, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Sohi, J, Kamholz, J, Kovari, L.C. | | 登録日 | 2010-08-05 | | 公開日 | 2011-12-21 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of the extracellular domain of human myelin protein zero.
Proteins, 80, 2012
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1TW7
 | | Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target | | 分子名称: | SODIUM ION, protease | | 著者 | Martin, P, Vickrey, J.F, Proteasa, G, Jimenez, Y.L, Wawrzak, Z, Winters, M.A, Merigan, T.C, Kovari, L.C. | | 登録日 | 2004-06-30 | | 公開日 | 2005-07-19 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target
Structure, 13, 2005
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3OTS
 | | MDR769 HIV-1 protease complexed with MA/CA hepta-peptide | | 分子名称: | MA/CA substrate peptide, Multi-drug resistant HIV-1 protease | | 著者 | Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C. | | 登録日 | 2010-09-13 | | 公開日 | 2011-03-30 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
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3OTY
 | | MDR769 HIV-1 protease complexed with RT/RH hepta-peptide | | 分子名称: | MDR HIV-1 protease, RT/RH substrate peptide | | 著者 | Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C. | | 登録日 | 2010-09-14 | | 公開日 | 2011-03-30 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
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3OUA
 | | MDR769 HIV-1 protease complexed with p1/p6 hepta-peptide | | 分子名称: | HIV-1 protease, p1/p6 substrate peptide | | 著者 | Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C. | | 登録日 | 2010-09-14 | | 公開日 | 2011-03-30 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
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3OU1
 | | MDR769 HIV-1 protease complexed with RH/IN hepta-peptide | | 分子名称: | MDR HIV-1 protease, RH/IN substrate peptide | | 著者 | Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C. | | 登録日 | 2010-09-14 | | 公開日 | 2011-03-30 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
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3OQ7
 | | Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants | | 分子名称: | HIV-1 Protease | | 著者 | Yedidi, R.S, Proteasa, G, Martinez-Cajas, J.L, Vickrey, J.F, Martin, P.D, Wawrzak, Z, Kovari, L.C. | | 登録日 | 2010-09-02 | | 公開日 | 2011-04-06 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.
Acta Crystallogr.,Sect.D, 67, 2011
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3OQA
 | | Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants | | 分子名称: | HIV-1 Protease | | 著者 | Yedidi, R.S, Proteasa, G, Martinez-Cajas, J.L, Vickrey, J.F, Martin, P.D, Wawrzak, Z, Kovari, L.C. | | 登録日 | 2010-09-02 | | 公開日 | 2011-04-06 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.
Acta Crystallogr.,Sect.D, 67, 2011
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3OU4
 | | MDR769 HIV-1 protease complexed with TF/PR hepta-peptide | | 分子名称: | HIV-1 protease, TF/PR substrate peptide | | 著者 | Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C. | | 登録日 | 2010-09-14 | | 公開日 | 2011-03-30 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
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3OU3
 | | MDR769 HIV-1 protease complexed with PR/RT hepta-peptide | | 分子名称: | HIV-1 protease, PR/RT substrate peptide | | 著者 | Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C. | | 登録日 | 2010-09-14 | | 公開日 | 2011-03-30 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
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3OUC
 | | MDR769 HIV-1 protease complexed with p2/NC hepta-peptide | | 分子名称: | MDR HIV-1 protease, p2/NC substrate peptide | | 著者 | Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C. | | 登録日 | 2010-09-14 | | 公開日 | 2011-03-30 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
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3OUD
 | | MDR769 HIV-1 protease complexed with CA/p2 hepta-peptide | | 分子名称: | CA/p2 substrate peptide, MDR HIV-1 protease | | 著者 | Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C. | | 登録日 | 2010-09-14 | | 公開日 | 2011-03-30 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
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3R0W
 | | Crystal Structures of Multidrug-resistant HIV-1 Protease in Complex with Mechanism-Based Aspartyl Protease Inhibitors. | | 分子名称: | Multidrug-resistant clinical isolate 769 HIV-1 Protease, N-[(2R)-1-{[(2S,3S)-5-{[(2R)-1-{[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino}-3-chloro-1-oxopropan-2-yl]amino}-3-hydroxy-5-oxo-1-phenylpentan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]pyridine-2-carboxamide | | 著者 | Yedidi, R.S, Gupta, D, Liu, Z, Brunzelle, J, Kovari, I.A, Woster, P.M, Kovari, L.C. | | 登録日 | 2011-03-09 | | 公開日 | 2012-04-04 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds.
Biochem.Biophys.Res.Commun., 421, 2012
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3SO9
 | | Darunavir in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant | | 分子名称: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, HIV-1 protease | | 著者 | Wang, Y, Liu, Z, Brunzelle, S.J, Kovari, L.C, Kovari, I.A. | | 登録日 | 2011-06-30 | | 公開日 | 2011-10-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | | 主引用文献 | The higher barrier of darunavir and tipranavir resistance for HIV-1 protease.
Biochem.Biophys.Res.Commun., 412, 2011
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3R0Y
 | | Crystal Structures of Multidrug-resistant HIV-1 Protease in Complex with Mechanism-Based Aspartyl Protease Inhibitors | | 分子名称: | Multidrug-resistant clinical isolate 769 HIV-1 Protease, N-[(2S)-1-{[(2S,3S)-3-hydroxy-5-oxo-5-{[(2R)-1-oxo-3-phenyl-1-(prop-2-yn-1-ylamino)propan-2-yl]amino}-1-phenylpentan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]pyridine-2-carboxamide | | 著者 | Yedidi, R.S, Gupta, D, Liu, Z, Brunzelle, J, Kovari, I.A, Woster, P.M, Kovari, L.C. | | 登録日 | 2011-03-09 | | 公開日 | 2012-04-04 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds.
Biochem.Biophys.Res.Commun., 421, 2012
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