4NKK

Crystal structure of a multi-drug resistant clinical isolate-769 HIV-1 protease variant that is resistant to the dimerization inhibitory activity of TLF-PafF

Summary for 4NKK

Entry DOI	10.2210/pdb4nkk/pdb
Related	1TW7 3PJ6
Descriptor	HIV-1 protease (2 entities in total)
Functional Keywords	hiv, aids, hiv-1 protease, dimerization inhibitors, protease inhibitors, multidrug-resistance, clinical isolate 769, dimer protease, hydrolase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	1
Total formula weight	10725.58
Authors	Yedidi, R.S.,Proteasa, G.,Kovari, L.C. (deposition date: 2013-11-12, release date: 2014-07-09, Last modification date: 2023-09-20)
Primary citation	Yedidi, R.S.,Proteasa, G.,Martin, P.D.,Liu, Z.,Vickrey, J.F.,Kovari, I.A.,Kovari, L.C. A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF. J.Mol.Graph.Model., 53C:105-111, 2014 Cited by PubMed: 25108107 DOI: 10.1016/j.jmgm.2014.06.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation