3PJ6

Crystal Structures of Multidrug-Resistant Clinical Isolate 769 HIV-1 Protease Variants

Summary for 3PJ6

Entry DOI	10.2210/pdb3pj6/pdb
Related	1TW7 3OQ7 3OQA 3OQD
Descriptor	HIV protease (2 entities in total)
Functional Keywords	alternate conformations of pro81, proline switch, wide-open flaps, expanded active site cavity, hydrolase
Biological source	Human Immunodeficiency Virus 1 (HIV-1)
Total number of polymer chains	1
Total formula weight	10725.58
Authors	Yedidi, R.S.,Proteasa, G.,Martinez-Cajas, J.L.,Vickrey, J.F.,Martin, P.D.,Wawrzak, Z.,Kovari, L.C. (deposition date: 2010-11-08, release date: 2011-04-06, Last modification date: 2023-09-06)
Primary citation	Yedidi, R.S.,Proteasa, G.,Martinez, J.L.,Vickrey, J.F.,Martin, P.D.,Wawrzak, Z.,Liu, Z.,Kovari, I.A.,Kovari, L.C. Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants. Acta Crystallogr.,Sect.D, 67:524-532, 2011 Cited by PubMed: 21636892 DOI: 10.1107/S0907444911011541 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation