4GZF

Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide

Summary for 4GZF

• Entry DOI: 10.2210/pdb4gzf/pdb
• Related: 4GYE
• Related PRD ID: PRD_000777
• Descriptor: Protease, LrF peptide (3 entities in total)
• Functional Keywords: multi-drug resistance, protease inhibitor, drug resistance, substrate peptides, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 3
• Total formula weight: 22375.41

Authors

Dewdney, T.G.,Wang, Y.,Kovari, I.A.,Brunzelle, J.S.,Reiter, S.J.,Kovari, L.C. (deposition date: 2012-09-06, release date: 2013-10-30, Last modification date: 2023-11-15)

• Primary citation: Dewdney, T.G.,Wang, Y.,Liu, Z.,Sharma, S.K.,Reiter, S.J.,Brunzelle, J.S.,Kovari, I.A.,Woster, P.M.,Kovari, L.C.; Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease.; Bioorg.Med.Chem., 21:7430-7434, 2013; PubMed: 24128815; DOI: 10.1016/j.bmc.2013.09.045

Experimental method

X-RAY DIFFRACTION (2.05 Å)