4GZF
Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protease | polymer | 99 | 10770.7 | 2 | UniProt (Q5RTL1) Pfam (PF00077) UniProt (by SIFTS) (Q9QM22) | Human immunodeficiency virus 1 | |
| 2 | C (C) | LrF peptide | polymer | 6 | 834.0 | 1 | BIRD (PRD_000777) | synthetic construct | |
| 3 | D, E, F (A, B, C) | water | water | 18.0 | 146 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: Q5RTL1)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
| Asn 25 | Asp 25 | engineered mutation |
| Val 36 | Met 36 | engineered mutation |
| Thr 82 | Ala 82 | engineered mutation |
| Val 84 | Ile 84 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 22375.4 | |
| All* | Total formula weight | 22375.4 |
