3SO9

Darunavir in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant

Summary for 3SO9

• Entry DOI: 10.2210/pdb3so9/pdb
• Related: 1RPI 1TW7 3OQ7 3OQA 3OQD 3SPK
• Descriptor: HIV-1 protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total)
• Functional Keywords: multi-drug resistance, hiv-1 protease, darunavir, protease inhibitor, hydorlase-hydorlase inhibitor complex, hydorlase/hydorlase inhibitor
• Biological source: Human immunodeficiency virus 1 (HIV-1)
• Total number of polymer chains: 2
• Total formula weight: 22089.04

Authors

Wang, Y.,Liu, Z.,Brunzelle, S.J.,Kovari, L.C.,Kovari, I.A. (deposition date: 2011-06-30, release date: 2011-10-12, Last modification date: 2024-02-28)

• Primary citation: Wang, Y.,Liu, Z.,Brunzelle, J.S.,Kovari, I.A.,Dewdney, T.G.,Reiter, S.J.,Kovari, L.C.; The higher barrier of darunavir and tipranavir resistance for HIV-1 protease.; Biochem.Biophys.Res.Commun., 412:737-742, 2011; PubMed: 21871444; DOI: 10.1016/j.bbrc.2011.08.045

Experimental method

X-RAY DIFFRACTION (2.87 Å)