3SO9
Darunavir in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HIV-1 protease | polymer | 99 | 10770.7 | 2 | UniProt (Q000H7) | Human immunodeficiency virus 1 (HIV-1) | |
| 2 | C (A) | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 1 | Chemie (017) PubChem (213039) PubChem (6320436) PubChem (6320437) PubChem (44400512) PubChem (44578485) PubChem (23545473) PubChem (66725685) PubChem (3001874) PubChem (89394603) PubChem (52949690) PubChem (102206609) PubChem (6320435) PubChem (125136514) PubChem (58330571) PubChem (60170302) PubChem (70329566) PubChem (89334570) PubChem (101897907) PubChem (102206607) PubChem (102206608) PubChem (118243427) PubChem (118243428) PubChem (118243429) PubChem (125136515) PubChem (129010372) PubChem (131632443) PubChem (131667685) PubChem (134694394) PubChem (137704505) PubChem (137704865) PubChem (138631483) PubChem (138631484) PubChem (138631622) PubChem (144227995) PubChem (145507139) PubChem (147231834) PubChem (156183881) PubChem (156183911) PubChem (171370671) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 142 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: Q000H7)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | SEE REMARK 999 |
| Asn 25 | Asp 25 | conflict |
| Glu 35 | Asp 35 | conflict |
| Val 36 | Ile 36 | SEE REMARK 999 |
| Leu 46 | Met 46 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21541.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 547.7 | |
| All* | Total formula weight | 22089.0 |
