3SO9
Darunavir in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HIV-1 protease | polymer | 99 | 10770.7 | 2 | UniProt (Q000H7) Pfam (PF00077) | Human immunodeficiency virus 1 (HIV-1) | |
| 2 | C (A) | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 1 | Chemie (017) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 142 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: Q000H7)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | SEE REMARK 999 |
| Asn 25 | Asp 25 | conflict |
| Glu 35 | Asp 35 | conflict |
| Val 36 | Ile 36 | SEE REMARK 999 |
| Leu 46 | Met 46 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21541.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 547.7 | |
| All* | Total formula weight | 22089.0 |
